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Dermatology > Structure and Function 1 > Flashcards

Structure and Function 1 Flashcards

1
Q

How many GP consultations for skin?

A

I in 5

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2
Q

Which germ layer is the epidermis made from?

A

Ectoerm cells form single layer periderm
Gradual increase in layers of cells
Periderm cells cast off

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3
Q

Which germ layer forms the dermis?

A

The dermis is formed from the MESODERM (below ectoderm)

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4
Q

KGPBD

A 
Keratin layer
Granular layer
Prickle cell layer
Basal layer
Dermis
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5
Q

Connective tissue, less cellular

A

Dermis

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6
Q

What is the sub-cutis mainly made from

A

Fat

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7
Q

The epidermis is 95% made from these cells

A

Keratinocytes

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8
Q

Epidermis is made of which type of cells?

A

Stratified squamous

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9
Q

How many layers in epidermis?

A

4

KGPB

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10
Q

Other cells found in the epidermis

A

Melanocytes
Langerhans cells
Merkel cells

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11
Q

Where do keratinocytes migrate from and what does this mean for the epidermis

A

Migrate from the basement membrane
Continous regeneration of epidermis
28 days from bottom to top

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12
Q

How many cells thick is the basal layer?

A

1 cell

Small cuboidal

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13
Q

Usually one cell thick
Small cuboidal
Lots of intermediate filaments (keratin)
Highly metabolically active

A

Basal layer

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14
Q

Lots of intermediate filaments in this layer

A

Basal layer

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15
Q

Larger polyhedral cells
Lots of desmosomes (connections)
Intermediate filaments connect to desmosomes

A

Prickle cell layer

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16
Q 
2-3 layers of flatter cells
Large keratohyalin granules – contain structural filaggrin & involucrin proteins 
Odland bodies (lamellar bodies)
High lipid content
Origin of “cornified envelope”
Cell nuclei lost
A

Granular layer

17
Q

Which layer are nuclei lost in?

A

Granular layer

18
Q

Which layer are odland bodies found?

19
Q

Which layer are lamellar bodies found in?

A

Granular

lamellar bodies = odland bodies

20
Q

Origin of “cornified envelope”

A

Granular layer

21
Q

Layer with a high lipid content?

A

Granular layer

22
Q

Where are corneocytes found?

A

Keratin layer

23
Q

What are corneocytes?

A

Overlapping non-nucleated cell remnants

24
Q

Where is the insoluble cornified envelope?

A

Keratin layer

25
Q

What do lamellar granules release?

A

Release lipid (in the granular layer)

26
Q

Which type of cell does HPV affect?

A

Keratinocytes

27
Q

Mucosa that is keratinised to deal with friction/pressure

A

Masticatory

Dermatology (27 decks)

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