Non-melanom skin cancer

Question 1

Leser-trelat sign

Answer 1

Sudden eruption of many seborrhoeic keratoses

malignant acanthosis nigricans

Question 2

Type of cyst seen in seborrhoeic keratosis?

Answer 2

Horn cysts can be seen in seborrhoeic keratosis

Question 3

Squamous cell carcinoma precursors

Answer 3

Bowens disease (red patches, more often females, especially legs)
Actinic keratosis (from sun)
Viral lesions (especially ano-genital skin)

Question 4

Erythroplasia of Queryat - what is this and what is it associated with?

Answer 4

Penile Bowen’s

Associated with HPV

Question 5

Chronic lupus vulgaris can give rise to which type of cancer?

Answer 5

Squamous carcinoma of the skin

Question 6

Commonest clinical setting of squamous carcinoma of the skin and other associations?

Answer 6

COMMONEST CLINICAL SETTING:
elderly, sun exposed sites (face, ears, dorsal hands)
UV implicated

OCCASIONALLY ARISES:
chronic leg ulcers e.g. stasis ulcers
sites of burns; sinuses e.g chronic osteomyelitis
chronic lupus vulgaris

RARE ASSOCIATIONS:
xeroderma pigmentosum; dystrophic variant epidermolysis bullosa

Question 7

Specific sites of squamous cell carcinoma that have a poorer prognosis?

Answer 7

Ear, nose, scalp

Question 8

Primary small cell neuroendocrine carcinoma of the skin

Answer 8

Merkel cell carcinoma

Question 9

Mycosis fungoides

Answer 9

Cutaneous T-cell lymphoma
Just looks like a big red rash tbh.. :(
Occurs in bathing suit area:
groin, lower trunk, buttocks, breast, axillae