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Dermatology > Psoriasis > Flashcards

Psoriasis Flashcards

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Dermatology Board Prep flashcards
1
Q

Retinoid

A

Form of vitamin A

Reduces skin turnover

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2
Q

Fumaric acid ester

A

Used in psoriasis treatment

Disrupts lymphocytes

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3
Q

distinctive acute skin eruption characterised by small drop-like, salmon-pink papules which usually have a fine scale

A

Guttate psoriasis

RECENT URTI SECONDARY TO GABHS OFTEN PRECEDES ERUPTION BY 2-3 WEEKS

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4
Q

Which type of psoriasis may be preceded by an URTI caused by Group A beta haemolytic strep?

A

Guttate psoriasis

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5
Q

Most commonly associated with streptococcal infection?

A

Guttate psoriasis

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6
Q

Chronic inflammatory disease of the pilosebaceous unit

A

Acneee

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7
Q

Which bacterium colonises the duct in acne?

A

P. acnes

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8
Q

Open comedone

A

Black head

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9
Q

Closed comedone

A

White head

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10
Q

Acne grading

A

Mild- scattered papules and pustules, comedones

Moderate - numerous papules, pustules &
mild atrophic scarring

Severe - as above, cysts, nodules and significant scarring

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11
Q

Benzoyl peroxide

A

Acne topical treatment

-keratolytic and antibacterial

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12
Q

Systemic treatment for Acne

A

Antibiotics
Isotretinoin (oral retinoid) – effect on sebaceous gland activity. Lot of side effects including initial aggravation of acne

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13
Q

Topical treatment for acne

A

CET (clindamycin, erythromycin, tetracycline)
Benzoyl peroxide – keratolytic, antibacterial
Topical vitamin A derivatives (retinoid): eg adapalene – drying effect
topical antibiotics – antibacterial and anti-inflammatory

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14
Q

Isotretinoin is an oral retinoid which can be used to treat acne. Name a side effect?

A

Can cause initial aggravation of acne§

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15
Q

How could you treat flare caused by isotretinoin?

A

Steroids and dapsone (anti-inflammatory)

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16
Q

What exacerbates rosacea?

A

Change in temperature
Alcohol
Spicy foods

-you could ask about this when taking a history

17
Q

Papules, pustules and erythema with no comedones

A

Rosacea

18
Q

How to reduce aggravating factors of rosacea?

A

Reduce aggravating factors:
dietary triggers
sun exposure – wear high factor sunscreen
avoid topical steroids

19
Q

Management for Rosacea?

A 
Antibiotics:
Topical metronidazole
Oral tetracycline long term
Isotretinoin low dose if severe
Telangiectasia : vascular laser
Rhinophyma: surgery/ laser shaving
20
Q

Rhinophyma

A

Enlarged nose (often in men) associated with Rosacea

21
Q

Difference between bullous pemphigoid and bullous pemphigus?

A

Bullous pemphigoiD –
split is Deeper, through DEJ.

PemphiguS –
split more Superficial, intra-epidermal

22
Q

Bullous pemphigoid and niklosky sign?

A

Bullous pemphigoid is niklosky sign NEGATIVE

niklosky sign is when you rub skin e.g. with eraser and if positive then blister will form within minutes

23
Q

Does bullous pemphigoid affect mucosa?

A

Unlikely

24
Q

Bullous pemphigoid and areas affected on the body?

A

localized to one area, or widespread on the trunk and proximal limbs

25
Q

Pemphigus vulgaris and niklosky sign?

A

Pemphigus vulgaris is niklosky sign positibe

26
Q

Pemphigus vulgaris and muscosal involvement?

A

Mucosal involvement is very common in pemphigus vulgaris

27
Q

Pemphigus vulgaris

A

Typically affects scalp, face, axillae, groins
Flaccid vesicles/bullae – thin roofed
Lesions rupture to leave raw areas
Increased infection risk
Nikolsky sign positive
Mucosal involvement (eyes, genitals) : very common

28
Q

Pemphigus vulgaris prognosis?

A

Chronic self- limiting course
Duration varies from months to years
Most patients achieve remission on treatment within 3 – 6 months
Pemphigus very high mortality if untreated
Pemphigoid up to 20% mortality I year treated

29
Q

Investigation for pemphigus vulgaris?

A

Skin biopsy with direct immunofluorescence

Indirect immunofluorescence

Dermatology (27 decks)

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