Stem Cells Flashcards

1
Q

What is a stem cell

A

A cell that has the ability to continuously divide and differentiate (develop) into various other kind(s) of cells/tissues

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2
Q

What are totipotent stem cells?

A

Each cell can develop into a
new individual cell

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3
Q

What are pluripotent stem cells?

A

Cells can form any cell type
(over 200)

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4
Q

What are multipotent stem cells?

A

Cells differentiated, but can
form a number of other tissues (e.g adult stem cells, cord blood)

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5
Q

What are unipotent stem cells

A

stem cells that are fully differentiated and can therefore only give rise to cells with identical phenotypic characteristics

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6
Q

what is the stem cell niche

A

area of the tissue in which stem cells reside in a dormant/ quiescent state

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7
Q

What are some ways a cell may receive signalling

A

Humoral, Neural, Mechanical/Structural

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8
Q

What are some examples of humoral signalling

A

Nutrients and growth factors coming from the blood

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9
Q

What are some examples of neural signalling?

A

Signals that come from surrounding tissues

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10
Q

What does stimuli influence in a stem cell?

A
  • Maintenance of quiescence
  • Self-renewal
  • Differentiation
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11
Q

What are some examples of structural/mechanical signalling?

A

Adhesion or interaction with the extracellular membrane

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12
Q

Where are some locations of stem cell niches?

A

Bone marrow
Skin
Central nervous system
Gut
Muscle

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13
Q

Where is the stem cell niche located in the bone marrow?

A

In the osteoblastic lining cells

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14
Q

Where are the stem cell niches located in the skin?

A

In bulges of hair follicle between the dermis and epidermis

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15
Q

What are two branches of stem cell niche in neuronal cells

A

Subventricular Zone and Subgradular Zone

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16
Q

where is the stem cell niches in the gut

A

found in the crypt of the gut epithelium

17
Q

Where are satellite cells located in the muscle?

A

between the basal lamina and sarcolemma

18
Q

Where can satellite cells be found in the cell cycle?

A

G0, they can then express a unique expression pattern which changes with the restart of the cell cycle

19
Q

What occurs when satellite cells are stimulated?

A

They can differentiate into different muscle precursors-myoblasts and they then differentiate into myofibers

20
Q

How do myofibers help repair the muscle?

A

Try and repair the muscle, calcium is released along with HGF

21
Q

What do you need to try and limit when fibres are damaged?

A

The release of Nitrous Oxide or any ROS

22
Q

Main points surrounding Embryonic stem cells

A

Derived from donated IVF embryos
* Can be grown indefinitely in the laboratory in an
unspecialised state
* Retain ability to specialise into many different
tissue types – know as pluripotent
* Can restore function in animal models following
transplantation

23
Q

Induced Pluripotent stem cells

A

Can be grown indefinitely in an undifferentiated state, have similar properties to embryonic stem cells, can be taken directly from patients for research

24
Q

How can we use stem cells in agriculture?

A

Reproducing the best breed
* Disease resistant
* Suitability to climate
* Quality body type
* Fertility
* Market preference

25
What is the therapeutic role of stem cells?
Treatment of musculoskeletal issues, Creating Transgenic animals (testing new drugs?), Preservation of Endangered species
26
What is the satellite cell pathway?
MyoD modulates Cdc 6 allowing the satellite cells to become myoblasts