Protein Coupled receptors Flashcards
What do Ligand Gated Channels control?
fast synaptic events in the NS
How fast does ligand binding occur?
within milliseconds
How does ligand binding occur?
ligand binds to a receptor and causes a conformational change which allows transit of ions across a membrane
What is different about ligand-gated ion channels compared to others?
no intermediate biochemical processes are required
G-Protein Coupled Receptors
involved in signalling associated with a wide range of biological processes
What is the structure of GPCR’s
7 membrane spanning alpha helixes
What are the three different families of GPCR’s?
A,B,C
What can Enzyme-Linked receptors be activated by?
growth factors, cytokines and hormones
What is the major role of enzyme-linked receptors/
growth and cell division, inflammation and immune responses
What are the main types of Enzyme-Linked receptors?
Receptor Tyrosine kinases, Receptor serine kinases and cytokine receptors
What is the common structure of kinase-linked receptors?
large extracellular binding domain connected via a single membrane spanning a-helix to the intracellular domain
RAS and PI3 Pathways
they play a key role in cell division, growth and differentiation and they are important targets for anti-cancer therapy
