Somato & Neruo 2 Flashcards
Dorsal root ganglion
Location of cell bodies (ncb) of first order sensory neurons
Support cells = satellite cells (sc)
Unmyelinated and myelinated axons (ma)
Spinal cord organization for sensory pathways
Dorsal column (funiculus)
2 divisions
Faciculus Gracilis - carries info abt caudal body & hindlimb
Faciculus cuneatus - carries info abt cranial body & forelimb
Grey matter organization
Rexed laminae 1-9
1 - pain & temp
2 - modulation
3 - touch
4 - touch
5 - pain
6 - position
7 - motor to viscera
8 - modulation
9 - motor to skeletal muscle
Dorsal Somatosensory pathways
Dorsal column system
Relays in for abt touch, position, vibration
First order neurons in dorsal SS pathway
Cell bodies in DORSAL root ganglion
Axon ascends in dorsal funiculus (dorsal columns
- hindlimb in Fas Gracilis (medial)
- forelimb in Fas cuneatus (lateral)
Synapses in nucleus Gracilis & cuneate nucleus in medulla
2nd order neuron Dorsal SS pathway
Cell body in brainstem nuclei
Axon crosses midline in medial lemniscus
Synapses in thalamus
3rd order neuron in dorsal SS pathway
Cell bodies in thalamus
Synapses in sensory cortex
Where 1st, 2nd, 3rd dorsal SS pathway synapse
1st - nucleus Gracilis & cuneate nucleus in medulla
2nd - thalamus
3rd - sensory cortex
Where orders cross in dorsal SS pathway
1st - axon ascends in dorsal funiculus
2nd - axon crosses at midline in medal lemniscus
3rd - cell bodies in thalamus
Lateral Spinothalamic tract
Relays information abt pain and temperature
Three neuron pathways
First neurons in lateral Spinothalamic tract
Cell body in dorsal root ganglion
Synapses in dorsal root of spinal cord
2nd neuron in lateral Spinothalamic tract
Cell body in dorsal horn of spinal cord
Axon crosses midline
Ascends in lateral funiculus
Synapses in thalamus
3rd neuron of lateral Spinothalamic tract
Cell body in thalamus
Synapses in sensory cortex
Where neurons synapse in lateral Spinothalamic tract
1st - dorsal horn of spinal cord
2nd - in thalamus
3rd - sensory cortex
Where axon crosses in lateral Spinothalamic tract
1st - cell body in dorsal root ganglion
2nd - crosses at midline
3rd - cell body in thalamus
Ventral Spinothalamic tract
Relays info abt light touch (non painful touch)
Three neuron pathways
First neuron in ventral spinolthalamic tract
Cell body in dorsal root ganglion
Synapses in dorsal horn of spinal cord
2nd neurons in ventral spinolthalamic tract
Cell body in dorsal horn of spinal cord
Axon crosses midline
Ascends in lateral funiculus
Synapses in thalamus
3rd order neuron in ventral spinolthalamic tract
Cell body in thalamus
Synapses in sensory cortex
Where neurons synapse in ventral spinolthalamic tract
1st - dorsal horn of spinal cord
2nd - in thalamus
3rd - sensory cortex
Where axon crosses in ventral spinolthalamic tract
1st - cell body in dorsal root ganglion
2nd - axon crosses midline
3rd - in thalamus
What tract handles touch, position, vibration
Dorsal somatosensory pathways
What tract handles pain & temperature?
Lateral Spinothalamic tract
What tracts handles light undiscriminated touch?
Ventral Spinothalamic tract
Other synapses in the spinal cord
Axons in the first order sensory neuron branch
Also synapse in local Interneurons
Basis of spinal reflexes
Modulation of ascending signals
Descending tracts
Motor
Lateral corticospinal tract (motor)
Ventral corticospinal tract (motor)
Ascending tracts
Sensory
Dorsal columns - Fine touch, Proprioception, vibration
Lateral Spinothalamic tract - pain, temperature
Ventral Spinothalamic tract - light touch
Spinoreticular tract
Pain modulation and response to pain
Spinovestibular tract
Information about posture and balance
Spinocerebellar tract
Unconscious proprioception
Thalamus
Diencephalon
Relay station for input to cerebral cortex
- all sensory information except olfaction
Located rostral to midbrain
Two halves join in midline at the inter thalamus adhesion (3rd ventricle)
Thalamic nuclei
Specialized for different sensory modalities
Also involved in motor system
Ventral nuclei = relay for somatosensory information
Primary somatosensory cortex
Located caudal to primary motor cortex
Areas of cortex correspond to body parts on opposite side of the body
Head - lateral
Tail - medial
Limbs - rostral
Somatotropic map
Areas with more sensory receptors have a larger area within the cortex
Function of an itch
Receptors: pruriceptors
Axons: C and A gamma
TRP receptors respond to chemical stimuli
Information ascends to the brain in the lateral Spinothalamic tract