Smith 5- Renal Flashcards
ARF in horses
- usually due to nephrotoxins or hypo perfusion/ischemia
- most common pathological lesion is acute tubular necrosis
amino glycoside toxicity causes ____ by ______?
- causes acute tubular necrosis
- accumulate within the renal proximal tubular epithelial cells, attach, cause swelling / death / sloughing
pigment nephropathy
following an episode of tying up or hemolysis
NSAID toxicity
medullary crest necrosis
- gross hematuria
acute interstitial nephritis
- ARF with rapid elevations in creat and CS of uremia
- NSAIDs in donkeys
leptospira interrogans
- fever, anorexia, depressio
- hematuria
- azotemia, isosthenuria
most common cause of ARF in foals
acute tubular necrosis
- often after D+ due to poor renal perfusion
chronic renal failure in horses
1) primary glomerular disease
2) primary interstitial disease
irreversible, progressive decline in GFR
most common glomerular dz of CRF in horses
proliferative glomerulonephritis
- immune complexes deposited, activated vasculitis , Type III hypersensitivity reaction
most common cause of CRF in older horses
chronic interstitial nephritis and fibrosis
-long term sequelae of ATN caused by toxins or vasomotor nephropathy
CS of CRF in horses
- weight loss
- small ventral edema
- moderate PUPD
- incisor / canine tartar, oral ulcers, melena
- moderate anemia and azotemia
- isosthenuria
PUPD
urine > 50ml/kg/day
intake > 100mL/kg/day
renal tubular acidosis
- hyperchloremic metabolic acidosis with a normal anion gap
- Type I: distal tubular excretion of H is compromised, cannot make acidic urine = normal pH
- Type II: decreased proximal tubular bicarb resorption and loss of bicarb in urine = acidic urine
pizzle rot
ulcerative posthitis, c.renale
-ulcerative bacterial infection of mm and skin
uroliths in ruminants
- high grain phosphorous : calcium ratio
- silica
- calcium from alfalfa
