Immune Dzs

Question 1

Lethal trait A46

Answer 1

• bovine hereditary zinc deficiency
• Edema dz
• hereditary thymus hypoplasia
• skin lesions, D+, bronchopneumonia
• 4-8 wks of age
• die at 4 mos
• zinc deficiency = decreased lymphocyte numbers and fn

Question 2

BLAD

Answer 2

• bovine leukocyte adhesion def
• holstein calves
• recurrent infections
• lack expression of the CD11/CD18 adhesion molecules on leukocytes
• persistent neutrophilia, hypoalbuin, hypoglobulin, hypoglycemia

Question 3

CVID

Answer 3

• inadequate antibody production from B cells
• adult onset recurrent infections and fevers
• DDX = lymphoma
• <2% B cells, CD8Ts may be increased

Question 4

Lymphosarcoma causes decreased immunoglobulins, especially ___

Answer 4

• IgM

- recurrent infections

Question 5

in the SRLV, the primary site of virus replication is

Answer 5

the macrophage

Question 6

SRLV infections are classed as

Answer 6

immunopathologic diseases, whereby the host immune response is responsible for most of the pathology rather than the virus itself.

Question 7

BLV virus causes

Answer 7

Lymphocytosis in 1/3 of animals - benign

Question 8

Non BLV lymphomas

Answer 8

Cutaneous
Thymic
Juvenile

Question 9

Enzootic lymphosarcoma (adult)

Answer 9

BLV associated

Question 10

BLV tumors

Answer 10

Less than 5% of affected animals have tumors

LNs, abomasum, and RA of heart are top 3 sites

Question 11

BLV transmission

Answer 11

Blood - needles, tagging equipment mostly

Some in utero