Small intestinal disorders and malabsorption Flashcards
barrier functions maintain a barrier against pathogens. it controls
immune sampling
monitoring of the presence of pathogens
translocation of bacteria
gut associated lymphoid tissue
small intestinal area has a …
cell types
villus architecture
constant turnover of cell in crypts and villi
the small intestine has a low bacterial population. Its toxic environment is full of
digestive enzymes
bile salts
presence of IgA
digestion starts in the stomach with the use of substances such as
salivary amylase
pepsin
digestion using proteins allows for
breakdown to oligopeptides and amino acids
final hydrolysis and absorption at brush border
digestion of fat involves
pancreatic lipase
absorption of free fatty acids and glycerol
carbohydrates digestion is by
pancreatic amylase
broken down to disaccharides
symptoms of small intestinal disorders
weight loss
increased appetite
diarrhoea
bloating
fatigue
steatorrhoea
fat malabsorption
high fat content in stool
stool less dense and floats
pals
foul smelling
signs of specific DEFICIENCIES include imbalances of….
iron
B12, folate
Ca2+, Mg2+
vitamin D
vitamin A
vitamin K
clubbing is specific to what digestive diseases?
coeliac disease
chrons
aphthous ulceration is specific to what digestive diseases?
coeliac
chrons
Dermatitis herpetiformis
cutaneous manifestation of coeliac disease
blistering, very itchy
tests of the structure of the small intestine
biopsy
barium study
CT scan
MRI
tests for coeliac disease
serology
IgA tests
HLA tests
