alimentary tract pathology Flashcards

1
Q

is the small bowel intraperitoneal?

A

NO

retroperitoneal

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2
Q

is the rectum retroperitoneal?

A

no

extraperitoneal

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3
Q

small bowel histology 3 cell types

A

goblet cells

columnar absorptive cells

endocrine cells

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4
Q

does the small bowel have crypts?

A

yes

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5
Q

large bowel histology is flat therefore there are no ……. they have ……

A

villi

crypts

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6
Q

both the small and large bowel peristalsis is mediated by intrinsic (…………) and extrinsic (………) neural control

A

myenteric plexus

autonomic innervation

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7
Q

myenteric plexus (or Auerbach plexus) is found

A

between the inner circular and outer longitudinal layers of the muscularis propria

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8
Q

meissener’s plexus is found at the

A

base of the submucosa

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9
Q

types of inflammatory bowel disease

A

ulcerative colitis

chrons disease

ischaemic colitis

radiation colitis

appendicitis

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10
Q

aetiology of IBD is the strong immune response to

A

normal flora with defects in the epithelial barrier function in genetically susceptible individuals

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11
Q

Chrons disease is a gene mutations on which gene?

A

NOD2

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12
Q

HLA associations in?

A

ulcerative colitis

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13
Q

Ulcerative colitis pathology

A

large bowel ONLY

continuous pattern of inflammation

pseudoplyps

ulceration

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14
Q

chrons disease pathology

A

granular seroa (dull grey)

mesentery is thickened

narrowing of lumen

sharp demarcation of disease segments from adjacent normal tissue

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15
Q

chrons histology

A

cryptitis and crypt abcesses

architectural distrotion

transmural inflammation

NON-CASEATING GRANULOMAS

fibrosis

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16
Q

long term feature of chrons

A

small intestine malabsorption

strictures

fistulas and abscesses

perforation

increased risk of cancer

17
Q

predisposing conditions for ischaemia

A

arterial thrombosis

arterial embolism

non-occlusive ischaemia

18
Q

what part of the large intestine is vulnerable in acute ischaemia?

A

splenic flexure

19
Q

acute ischaemia histology includes

A

oedema

interstitial haemorrhages

necrosis of mucosal outlines

vascualr dilatation

20
Q

chronic ichaemia leads to the development of…

A

mucosal inflammation

ulceration

submucosal inflammation

fibrosis

stricture

21
Q

Radiation colitis

A

Abdominal irradiation can impair the normal proliferative activity of the small and large bowel epithelium

22
Q

symptoms of radiation colitis

A

anorexia

abdominal cramps

diarrhoea

malabsorption

23
Q

radiation colitis histology

A

bizarre cellular changes

inflammation of crypt abscess

lateral-arterial stenosis

ulceration

haemorrhage

24
Q

appendicitis can cause an increase in intraluminal….

A

pressure

which can lead to ischaemia

25
Q

appendicitis histology

A

abcess

inflammation in wall and pus in lumen

necrosis

26
Q

3 types of adenoma (‘polyps’)

A

tubular

villous

tubulovillous

27
Q

low grade dysplasia in an adenoma allows for…

A

increased nuclear numbers

increased nuclear size

reduced mucin

28
Q

high grade dysplasia in an adenoma allows for….

A

carcinoma in situ

crowded

very irregular

not yet invasive

29
Q

right sided colorectal adenocarcinoma can lead to…

A

anaemia

vague pain

weakness

obstruction

30
Q

left sided colorectal adenocarcinoma can lead to..

A

annular (napkin ring legion)

bleeding

altered bowel movements

obstruction