Hepatic-Biliary Pathology Flashcards

1
Q

artery supplying liver

A

hepatic artery

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2
Q

vein draining liver

A

portal vein

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3
Q

functions of the liver

A

protein synthesis

metabolism of fat and carbohydrate

detoxification of drugs and toxins (including alcohol)

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4
Q

Common conditions of liver

A

liver failure

jaundice

intrahepatic bile duct obstruction

cirrhosis

tumours

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5
Q

common condition of gall bladder

A

inflammation

cholecystitis

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6
Q

common condition of extra hepatic bile ducts

A

obstruction

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7
Q

liver failure can be a complication of

A

acute liver injury

chronic liver injury (cirrhosis)

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8
Q

acute liver injury can be down to

A

hepatitis (viruses, alcohol, drugs)

bile duct obstruction

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9
Q

viral hepatitis

A

hep A

hep B

hep C

hep E

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10
Q

pathology of viral hepatitis

A

inflammation of liver

liver cell damage and death of individual liver cells

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11
Q

outcome of acute inflammation

A

resolution (return to normal)

liver failure if severe damage to liver

progression to chronic hepatitis and cirrhosis

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12
Q

Alcoholic liver disease is a fatty change. results in

A

alcoholic hepatitis

progression to cirrhosis

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13
Q

alcoholic hepatitis leads to

A

acute inflammation

liver cell death

liver failure

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14
Q

Jaundice is a result of

A

increased circulating bilirubin

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15
Q

jaundice is caused by the altered metabolism of

A

bilirubin

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16
Q

pre-hepatic jaundice

A

increased release of haemoglobin from red cells

haemolysis

17
Q

hepatic jaundice

A

cholestasis

intra-hepatic bile duct obstruction

18
Q

cholestasis

A

accumulation of bile within hepatocytes or bile canaliculi

19
Q

causes of cholestasis

A

viral hepatitis

alcoholic hepatitis

liver failure

drugs (therapeutic, recreational)

20
Q

intra-hepatic bile duct obstruction be caused by

A

primary biliary cholangitis

primary sclerosing cholangitis

tumours of liver (hepatocellular carcinoma/ adenocarcinoma)

21
Q

primary biliary cholangitis

A

organ specific auto-immune disease

mainly affects females (9:1)

22
Q

cholangitis

A

inflammation of the bile duct

23
Q

pathology of primary biliary chloangitis

A

granulomatous inflammation involving bile ducts

loss of intra-hepatic bile duct

24
Q

primary biliary cholangitis can often develop into

A

cirrhosis

25
Q

primary sclerosing cholangitis

A

chronic inflammation and fibrous obliteration of bile ducts

loss of intra-hepatic of bile ducts

associated with inflammatory bowel disease

26
Q

primary sclerosing cholangitis can often progress into

A

cirrhosis

cholangiocarcinoma

27
Q

causes of cirrhosis

A

alcohol

hep B,C

immune mediated liver disease

metabolic disorders

obesity

28
Q

pathology of cirrhosis

A

diffuse process involving whole liver

loss of normal liver structure

replaced by nodules of hepatocytes and fibrous tissue

29
Q

complication of cirrhosis

A

altered liver function

abnormal blood flow

increased risk of hepatocellular carcinoma

30
Q

liver tumour examples

A

hepato-cellular carcinoma

cholangio carcinoma

metastatic tumours

31
Q

post-hepatic jaundice

A

cholelithiasis (gall stones)

diseases of the gall bladder

extra-hepatic duct obstruction

32
Q

risk factors for gall stones

A

obesity

diabetes

33
Q

chronic cholecystitis

A

chronic inflammation and fibrosis of gall bladder

34
Q

gallstones leads to inflammation called

A

acute and chronic cholecystitis

35
Q

acute cholecystitis

A

acute inflammation of the gall bladder (empyema)

progression to chronic inflammation

36
Q

causes of common bile duct obstruction

A

gall stones

bile duct tumours

benign stricture

external compression

37
Q

effects of a common bile duct obstruction

A

jaundice

no bile excreted into the duodenum

infection of bile proximal to obstruction

secondary biliary cirrhosis