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Disease and Defense > Skin Neoplasms > Flashcards

Skin Neoplasms Flashcards

1
Q

_____ (sex) are ____ times as likely to get basal cell carcinoma and _____ times as likely to get squamous cell carcinoma

A

Men; 2; 3

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2
Q

_____ in an inhibitor of Smoothened used to treat _______

A

Vismodegib; Basal cell carcinoma

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3
Q

_____ is an inhibitor of BRAF used to treat _______

A

Vemurafinib; melanoma

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4
Q

______ nevi: dermal epidermal junction above the basement membrane zone of the epidermis

A

Junctional

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5
Q

______ nevi: exclusively in the dermis

A

Intradermal

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6
Q

______ nevi: irregular outline, variable pigmentation, indistinct borders, can be enlarged

A

Dysplastic

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7
Q

______ nevi: melanocytes in dermal epidermal junction and within the dermis

A

Compound

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8
Q

_______ Kaposi’s sarcoma: aggressive form in equatorial Africa, affects young men, rapidly fatal

A

lymphadenopathic

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9
Q

_______ Kaposi’s sarcoma: elderly men of Eastern European descent

A

Classic

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10
Q

_____: describes the degree of penetration into the skin in terms of physiologic levels

A

Clark level

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11
Q

____: measurement of thickness in millimeters

A

Breslow depth

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12
Q

Basal cell carcinoma results from a loss of function mutation in ______ with normally blocks ______.

A

PTCH1 (Patch 1); Smoothened (SMO)

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13
Q

Endothelial cell neoplasms

A

Cherry angioma, hemangioma, port wine stain

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14
Q

Fibroblast neoplasms

A

Dermatofibroma

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15
Q

Melanocyte neoplasms (4)

A

Nevi, ephelides (freckles), lentigo, Café au lait macule

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16
Q

Melanoma distribution for blacks, women, and men

A

Acral and mucosa; legs; back

17
Q

Melanoma results from mutations most commonly in _____ (50%) or _____ (20%)

A

BRAF; NRAS

18
Q

Most common malignancy in the US

A

Basal cell carcinoma

19
Q

Most important prognostic indicator in melanoma: ______

A

Breslow depth

20
Q

Sebacous gland neoplasms

A

Sebaceous hyperplasia, nevus sebaceous

21
Q

Smoking is a risk factor for _______ only

A

Squamous Cell Carcinoma

22
Q

Subtypes of Basal Cell Carcinoma (4)

A

Nodular, Superficial, Infiltrative, Sclerosing

23
Q

Subtypes of Melanoma (4)

A

Superficial spreading, Nodular; Lentigo Maligna; Acral lentiginous

24
Q

Subtypes of Squamous Cell Carcinoma (3)

A

Keratoacanthoma, infiltrative, in situ

25
Q

What pathology? Benign: most common on chest and back, also scalp, face, neck and extremities; papillary epidermal hyperplasia with proliferation of basal layer cells

A

Seborrheic keratoses

26
Q

What pathology? benign: primary truncal bright red smooth-topped papules

A

Cherry Angioma

27
Q

What pathology? Benign: yellow-white papule with central dell, distribution: face > trunk > extremities

A

Sebaceous hyperplasia

28
Q

What pathology? brown, firm papules most commonly on legs of adults, dimple sign of downward movement of tumor upon pinching

A

Dermatofibroma

29
Q

What pathology? dermal proliferation of capillary-sized endothelial cell-lined vessels, cells stain with placenta associated markers

A

Infantile Hemangioma

30
Q

What pathology? hamartoma that is a yellow-orange linear plaque with rapid growth at puberty

A

Nevus sebaceous

31
Q

What pathology? hyperkeratotic papule with variable size and thickness, typically found on chronically sun-damaged skin, metastasis most common in the lip

A

Squamous Cell Carcinoma

32
Q

What pathology? Malignant: flat, firm, pale areas or small raised pink/red translucent shiny waxy areas that may bleed after minor injury

A

Basal cell carcinoma

33
Q

What pathology? Malignant: nodule with central keratin plug

A

Keratoacanthoma

34
Q

What pathology? Most common benign tumor of childhood, vascular proliferations

A

Infantile Hemangioma

35
Q

What pathology? Most common premalignant lesion, hyperkeratosis and erythematous papules, risk for ________

A

Actinic keratoses; Squamous Cell Carcinoma

36
Q

What pathology? oval, slightly raised, light brown to black papules or plaques

A

Seborrheic keratoses

37
Q

What pathology? skin tag in areas of skin rubbing

A

Acrochordons

38
Q

What pathology? vascular malformations that do not resolve spontaneously

A

Port Wine Stain

Disease and Defense (16 decks)

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