Neoplasms and Cancer Flashcards
Aggressive lung tumors that metastasize widely, especially to the brain
Small cell carcinoma
Benign or malignant? Cytologic uniformity
Benign
Benign or malignant? general loss of boundary between tumor and adjacent tissue
Malignant
Benign or malignant? Invasive, metastasizes
Malignant
Benign or malignant? cause injury both by local tissue destruction and distant dissemination and tissue destruction
Malignant
Benign or malignant? circumscribed/encapsulated
Benign
Benign or malignant? High rate of cell turnover
Malignant
Benign or malignant? injury by compression interference of adjacent structures
Benign
Benign or malignant? Necrosis
Malignant
Benign or malignant? well differentiated
Benign
Bind to interior surface of microtubule, stabilize microtubule against de-polymerization
Taxanes
Bind to tubulin at ends, stabilizing them
Vinca Alkaloids
In ______ tissues, there is little or no capacity for proliferation
non-dividing
In ______ tissues, there is normally little or no turnover but there is capacity for proliferation if needed
quiescent
Lung carcinoma characterized by cells attempting to form primitive gland-like structures (stain positive for mucin)
Adenocarcinoma
Lung carcinoma characterized by metaplasia of pseudostratified ciliated columnar epithelium to squamous epithelium
Squamous cell carcinoma
Moderately well differentiated adenocarcinomas arising in mucosal layer of bowel
Colorectal carcinoma
Name the drug class: 5-Flurouracil
Anti-metabolite
Name the drug class: Anthracyclines
Topoisomerase Inhibitor
Name the drug class: Aromatase Inhibitors
Hormonal Agents
Name the drug class: Bicalutamide
Hormonal Agents
Name the drug class: Carboplatin
Cisplatin Analogue
Name the drug class: Etosopide
Topoisomerase Inhibitor
Name the drug class: Flutamide
Hormonal Agents
Name the drug class: GNHR Analgoues
Hormonal Agents
Name the drug class: Herceptin
Antibody
Name the drug class: Imatinib
Kinase Inhibitor
Name the drug class: Methotrexate
Anti-metabolite
Name the drug class: Nitrogen Mustard
Alkylating Agent
Name the drug class: Oxaliplatin
Cisplatin Analogue
Name the drug class: Rituximab
Antibody
Name the drug class: Tamoxifen
Hormonal Agents
Name the drug class: Taxanes
Anti-Microtubule Agent
Name the drug class: Vinblastine
Anti-Microtubule Agent
Name the drug class: Vincristine
Anti-Microtubule Agent
Pyrimidine Analog that is metabolized by thymidine kinase and inhibits DNA synthesis
5-Fluorouracil
Reversible, competitive inhibitor of DHFR, which is required for purine nucleotide synthesis
Methotrexate
Tumor Stage: T1/T2, N0, M0
I
Tumor Stage: T1/T2, N1, M0
IIIA
Tumor Stage: T3, N0, M0
IIA
Tumor Stage: T3/T4, N2, M0
IIIB
Tumor Stage: T4, N0, M0
IIB
Tumor Stage: Tany, N2, M0
IIIC
Tumor Stage: Tany, Nany, M1
IV
Types of lung carcinoma most linked to smoking
Small cell and squamous cell
Undifferentiated high grade lung cancer where cells may not produce keratin or mucin
Large cell carcinoma
What type of malignant tumor is characterized by having a pre-malignant lesion and an in-situ phase?
Carcinoma
