Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Disease and Defense > Anti-Inflammatory Pharmacology > Flashcards

Anti-Inflammatory Pharmacology Flashcards

1
Q

COX-__ is activated constitutively.

A

1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Acetaminophen is different from tNSAIDs in that it has no _______ effect

A

anti-inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Acetaminophen overdose can be treated with _______.

A

acetylcysteine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Alcoholic liver disease may be a contraindication for which drug?

A

acetaminophen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Aldosterone _______ reabsorption of sodium in the distal tubules of the kidney and _______ secretion of protons and potassium ions

A

increases; increases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Aspirin is different from tNSAIDs in that it has a ________ effect

A

anti-aggregatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Aspirin is different from tNSAIDs pharmacodynamically in that it binds ________.

A

irreversibly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cardiovascular disorders may be a contraindication for which drug?

A

celecoxib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Chronic renal insufficiency is a contraindication most significantly for which drug?

A

aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Coagulation disorders are a contraindication for which drugs?

A

aspirin and tNSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

COX-__ in platelets has a/an ___-coagulatory effect

A

1; pro

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

COX-___ in endothelial cells has aan ___-coagulatory

A

2; anti

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

GI irritation is a contraindication for which drugs?

A

aspirin and tNSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Glucocorticoids _____ production of mineralocorticoids, such as aldosterone

A

decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Glucocorticoids _____ vasodilation and ______ fluid exudation

A

decrease; decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Glucocorticoids ______ (induce/inhibit) COX-___.

A

inhibit; 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Glucocorticoids ______ (induce/inhibit) lipocortins, which _____ (induce/inhibit) _______

A

induce; inhibit; Phospholipase A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Glucocorticoids ______ accumulation and activation of inflammatory and immune cells

A

decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Glucocorticoids ______ healing and ______ immunoprotection

A

decrease; decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Greatest suppression of ACTH secretion at pituitary

A

Dexamethasone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Hypothalamic-pituitary-adrenal axis suppression occurs with extended use of _______.

A

glucocorticoids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

In endothelial cells, COX-___ promotes vaso_____ and has ____-aggregatory effects

A

2; dilation; anti

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

In kidneys, COX-__ maintains renal blood flow, which is critical in the elderly and those with compromised renal function

A

2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

In platelets, COX-__ has ___-aggregatory effects.

A

1; pro

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

In the ductus arteriosus, COX-___ the patent ductus arteriosus is maintained by vasodilation

A

2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

In the GI tract, COX-___ _______ acid secretion, _______ mucous/bicarbonate production, has cytoprotective effects, and _______ smooth muscle contractions

A

1; decreases, increases, increases

27
Q

In the hypothalamus, COX-___ is involved in fever production.

A

2

28
Q

In the kidneys, COX-__ _____ renal blood flow and promotes diuresis

A

1; increases

29
Q

In uterine smooth muscle, COX-___ promotes labor contractions.

A

2

30
Q

In vascular smooth muscle, Cox-1 produces prostaglandins that promote vaso______ and thromboxanes that promote vaso_____.

A

dilation; constriction

31
Q

Metabolic effect of glucocorticoids: ______ gluconeogenesis

A

increase

32
Q

Metabolic effect of glucocorticoids: _______

A

increase

33
Q

Metabolic effect of glucocorticoids: _______ amino acid uptake into liver and kidney

A

increase

34
Q

Metabolic effect of glucocorticoids: _______ protein synthesis

A

decrease

35
Q

Metabolic effect of glucocorticoids: _______ uptake of glucose by fat cells

A

decrease

36
Q

Metabolic effect of glucocorticoids: transfer of amino acids from _______ to the ____

A

muscle and bone; liver

37
Q

Most common oral agent for steroid burst therapy

A

prednisone

38
Q

Most potent anti-inflammatory agent

A

dexamethasone

39
Q

No anti-mineralocorticoid activity

A

triamcinolone and dexamethasone

40
Q

Potent system agent with excellent topical activity

A

Triamcinolone

41
Q

Pregnancy is a contraindication for which drugs?

A

aspirin, tNSAIDs, and celecoxib

42
Q

Prostacyclin is important for vaso_____ and ___-aggregation

A

dilation; anti

43
Q

Prostaglandin-related side effect: _______: COX-1 and COX-2 in kidney cells

A

renal dysfunction

44
Q

Prostaglandin-related side effect: _______: COX-1 in gastric cells

A

ulceration and bleeding

45
Q

Prostaglandin-related side effect: _______: COX-2 in endothelial cells

A

Increased thrombotic events

46
Q

Prostaglandin-related side effect: _______: COX-2 in uterine smooth muscle

A

Delayed labor

47
Q

Sulfa-allergies may be a contraindication for which drug?

A

celecoxib

48
Q

Supratherapeutic acute doses of which drug can cause dizziness, excitement, and disorientation?

A

acetaminophen

49
Q

The following symptoms suggest over dose of which drug? Headache, dizziness, diarrhea, tinnitus, visual disturbances, mental confusion, drowsiness, sweating, thirst, hyperventilation

A

aspirin

50
Q

The following symptoms suggest over dose of which drug? vomiting, sweating fever, respiratory alkalosis, metabolic acidosis

A

aspirin

51
Q

Therapy strategy that lessens growth-suppressive effect because anti-inflammatory actions last longer than suppressive effect on HPA axis

A

Alternate Day Therapy

52
Q

Therapy strategy that minimizes rebound of disease; also uses to allow for recovery of HPA axis

A

Tapered Withdrawal

53
Q

Thromboxane is important for vaso_____ and ____-aggregation

A

constriction; pro

54
Q

Thromboxane-related side effect: _______: COX-1 in platelets

A

Increased bleeding risk

55
Q

Use in children younger than 12 with viral infection is a contraindication for which drug?

A

aspirin

56
Q

Used if parenteral administration is desired for steroid burst

A

methylprednisone

57
Q

Which drug is safest for overdose: aspirin, tNSAIDs, or acetaminophen?

A

tNSAIDs

58
Q

Which drugs can have bleeding as a side effect?

A

aspirin and tNSAIDs

59
Q

Which drugs can have clotting as a side effect?

A

celecoxib

60
Q

Which drugs can have GI upset as a side effect?

A

aspirin and tNSAIDs

61
Q

Which drugs can have labor suppression as a side effect?

A

aspirin, tNSAIDs, and celecoxib

62
Q

Which drugs can have renal dysfunction as a side effect?

A

aspirin, tNSAIDs, and celecoxib

63
Q

Which drugs do not target COX-1?

A

Acetaminophen and Celecoxib

64
Q

Which glucocorticoid agents can be administered topically?

A

hydrocortisone, triamcinolone, and dexamethasone

Disease and Defense (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions