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Pathology > Skin > Flashcards

Skin Flashcards

1
Q

Most deadly of all skin Cancer

A

Melanoma

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2
Q

Which growth phase of Melanoma is worrisome? Radial or Vertical

A

Vertical phase - has a metastatic potential

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3
Q

Aside from Melanoma with “red nucleoli”, What other malignancy has a prominent nucleoli?

A

Prostatic acinar adenocarcinoma

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4
Q

Melanoma cells stains positive for?

A

S-100 —- neural crest cell marker

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5
Q

Melanoma cells stains also stains for?

A

HMB-45 —- melanocyte marker

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6
Q

Epidermal tumor with a morphology of Basaloid cells, hyperkeratosis, Horn cyst, invagination cyst?

A

Seborrheic Keratosis

benign
Leser-trelat sign
Cyst - keratin filled
tumor produces TGF- a (keratinocyte stimulation)

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7
Q

thickened, hyperpigmented skin with a velvet like texture in flexural areas

A

Acanthosis Nigricans

undulation of epidermis and dermal papillae
Hyperkeratosis
Basal cell hyperpigmentation

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8
Q

Epidermal tumor with Premalignant to SCC?

A

Actinic Keratosis
hyperkeratotic lesion occurs in sun-damaged skin

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9
Q

MC invasive Cancer in human

A

BCCa

pearly papules with telangiectasia – rodent ulcer
nest of basaloid cells with peripheral palisading
stromal retraction

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10
Q

6Ps of Lichen Planus

A

Pruritic, purple, polygonal, planar, papules, and plaques

Wickham striae = white dots on papules
CD8+ T cell mediated hypersensitivity

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11
Q

pinpoint bleeding on lifting scales on Psoriasis

A

Auspitz sign

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12
Q

Morphology seen in Psoriasis

A

Acanthosis with elongation of rete ridges
absent stratum granulosum
Munro microabscesses
Spongiform of Kogoj

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13
Q

It is neutrophils within the parakeratotic stratum corneum

A

Munro microabscesses

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14
Q

Neutrophils in spongiotic foci of the superficial epidermis

A

Spongiform pustules of Kogoj

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15
Q

Pemphigus is most commonly associated with?

A

NHL

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16
Q

Dermatitis herpetiformis is assoc with:

A

Celiac disease

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17
Q

keratinization with retained nuclei in the stratum corneum

A

Parakeratosis

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18
Q

Direct precursor of melanoma
marker of increase melanoma risk

A

Dysplastic nevus

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19
Q

Melanocytic, Dysplastic and melanomas shared these mutation

A

RAS/BRAF mutations

20
Q

MC mutation found in Melanoma

A

TERT

21
Q

Melanocyte is derived from

A

Neural crest cell

22
Q

Squamous cell Carcinoma assoc with

A

Epidermodysplasi verruciformis

23
Q

2nd MC tumor arising on sun-exposed skin
keratin pearls
dyskeratotic cells
plaque to nodules with ulceration

A

squamous Cell Carcinoma

24
Q

Wickham striae
Koebner phenomenon
hypekeratosis & Hypegranulosis
Sawtoothing of epidermal-dermal junction
Civatte bodies

A

Lichen planus

25
Q

Anucleate, necrotic basal cells incorporated into inflamed papillary dermis

A

Civatte (colloid) bodies

26
Q

Salmon colored plaque with silver white scales
Cell mediated CD4 CD8
Auzpits sign
Koebner phenomenon

A

Psoriasis

27
Q

Morphology of Psoriasis

A

test tube in a rack appearance
Munro Microabscess
spongiform of kogoj

28
Q

MC inflammatory Blistering disease

A

Pemphigus vulgaris

desmoglein (desmosome)
IgG
Suprabasilar
Acantholysis
+ Nicolysky sign

29
Q

Hemidesmosome
IgG
loc: Basement membrane
Basal cell layer vacuolization
- Nikolysky sign

A

Bullous Pemphigoid

30
Q

Target: Reticulin
Supedermal
IgA, tips of Dermatitis herpetiforms
- nickosky sign
Fibrin and neutrohil at the tip

A

Dermatitis Herpetiformis

31
Q

top layer of the skin SLIP AWAY from the lower layers WHEN RUBBED

A

Nikolsky sign
seen in Phemphigus vulgaris

32
Q

Molluscum boy: ellipsoid, Cytoplasmic inclusion in keratinocytes
pink pearly firm papule with umbilicated center

A

Molluscum contagiosum

33
Q

acute infection with VZV,
Latent infection

A

Varicella
Zoster

HM: Intraepidermal vesicles with intranuclear inclusion in keratinocytes

34
Q

MC complication of VZV

A

MC: Post-herpetic neuralgia
Ramsay Hunt syndrome- Facial paralysis
Herpes Zoster Opthalmicus

35
Q

Chronic suppurative infection of the apocrine gland

A

HIdradenitis

36
Q

Neutrophilic accumulation beneath stratum corneum
Honey-colored crusting

A

Impetigo

37
Q

Impetigo Contagiosa cause by

A

S. pyogenes

38
Q

Impetigo Bullosa cause by

A

S. aureus

39
Q

Premature keratinization within cells below stratum granulusom

A

Dyskeratosis

40
Q

Spinosum + Basale layer =

A

Germinativum

41
Q

Langerhans cells commonly seen in

A

Spinososum layer

42
Q

Intercellular edema of the epidermis

A

Spongiosis

43
Q

pigmented nevus, mole
nested melanocytic hyperplasia
Neurotization
benign lesion

A

Melanocytic nevus

44
Q

larger variegated surface, irregular border
epidermal and dermal involvement, archi and cytologic atypia
precursor to melanoma

A

Dysplastic nevus

45
Q

skin layer not seen in THIN SKIN

A

Lucidum layer

  • flat eosinophilic keratinocytes

Pathology (18 decks)

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