Kidney Flashcards
MCC of nephritic syndrome in children
PSAGN
laboratory findings of PSAGN
inc ASO, dec C3
IF: IgG, C3
EM: subepithelial humps on GBM
Hypercelullar glomeruli
Histologic hallmark of RPGN
LM: crescents (Cresentic GN)
Common disease of RPGN type I
anti-GBM disease
Goodpasture syndrome
+ antibodies against GBm
IF: Linear
Common disease of RPGN II
PSAGN
Lupus nephritis
HSP
Berger disease
complication of immune complex – glomerular injury
EM: Lumpy-Bumpy appearance of GBM
IF: Granular
Disease in RPGN type III
ANCA vasculitides
(+) p-ANCA
IF: Negative immune deposits
20, Male, Smoker, with hemoptysis and renal failure
Good pasture syndrome
MCC of nephrotic syndrome in Children
Minimal Change disease/ Nil disease
LM: N glomerulus
EM: effacement of foot processes of the podocytes
MCC of Nephrotic syndrome in adults
FSGS
+azotemia
association:
HIV
sickle cell anemia
Obesity
IgA nephropathy
LM: inc mesangial matrix, collapsing glomerulopathy
2nd MC nephrotic syndrome in adult
LM, EM
Membranous nephropathy
LM: diffuse thickening of the capillary wall
EM: Subepithelial deposits along the GBM (spike and dome), effacement of foot processes
with complex deposition
LM: large, hypercellular glomeruli, thickened GBM (double-contour tram track
EM: subendothelial deposits
IF: C3 with IgG
MPGN I
MPGN II
IF: C3, EM: ribbonlike
MC type of GN worldwide
IgA nephropathy/Berger disease
IgA deposition localized to kidneys
gross hematuria after a respi/GI/GU infection
MC GN in children 3-8 yrs old
HSP
systemic IgA deposition
+ purpuric skin lesion, renal abnormalities following RTI
kidney condition associated with long-standing diabetes
Kimmelstiel-Wilson nodules
CKD with large kidneys
DM
HIV
Amyloidosis
PCKD
MCC of AKI
Acute Tubular Injury
MCC Renal artery stenosis
Atherosclerosis
2nd: Fibromuscular dysplasia
MCC of Renal infarct
Embolism
morpho: white infarct / coagulative necrosis
Renal mass
Hematuria
Pain
CKD
ADPKD
assoc anomalies: Liver cyst
intracranial berry aneurysm
MVP
MC death: Coronary/HTN heart dse
MCC renal tumor in kidney
RCC
2nd MC: Wilms tumor
3rd MC: Urothelial Ca
associated conditions in Calcium oxalate stones
Hypercalcemia
Hypercalciuria
Hyperoxaluria
Acidic pH
Kidney stone associated with Proteus infection, and Urease
Struvite
Basic pH
morpho of Calcium oxalate
Colorless, OCtahedron
Morpho of Struvite
Colorless, COFFIN-LID
Opaque
Morpho of Uric Acid
yellow, red brown to brown, rhombic
lucenct
pH Acidic
Morpho of Cystine stone
Colorless Hexagonal plate
ph acidic
opaque
assoc with Cystinuria
TRIAD OF RCC
hematuria
Mass
Flank pain
mets: Lungs > Bone
MC histologic type of RCC
Clear Cell 70-80%
Origin: PTC
AD syndrome: VHL syndrome
Histo type of RCC
+ Papillary formation
+ Psammoma bodies
Cystic, Hemorrhagic masses
Papillary RCC
origin: DTC
AD syndrome of Chromophobe RCC
Birt- Hogg-Dube syndrome
Histo of Chromophobe RCC
pale eosinophil often with perinuclear halo
origin: intercalated cells of CD
