Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathology > Bone, Soft Tissue > Flashcards

Bone, Soft Tissue Flashcards

1
Q

Bone tumor associated with McCune Albright syndrome (polyostic FD, cafe-au-lait spots, endocrine abnormalities?

A

Fibrous Dysplasia — Chinese characters
no osteoblastic rimming

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Radiographic result of Osteosarcoma:

A

Codman triangle (perisoteal lifting
sunburst appearance (infiltrative disorders)
lytic and blastic lesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Bone tumor of Hyaline cartilage that occurs in bones of endochondral origin

A

Chondroma
loc: metaphysis
Assoc: Ollier and Maffuci syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Micro: Small round blue cells and Homer Wright rosette
Radio: lytic lesion, Periosteal reaction: Onion-skin
Diaphysis located

A

Ewing Sarcoma
2nd MC group of bone sarcomas in children
mutation in t(11;22) EWSR1-FLI1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Avascular necrosis of ossification center in children

A

Legg-Calve Perthes Disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

MC causative agent of Osteomyelitis

A

S. aureas (MC)
GUT infection: E,coli, Pseudomonas, Klebseilla
Neonates: H. influenza, GBS
Sickle Cell Dse: Salmonella

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

MC skeletal Dysplasia
major cause of DWARFISM

A

Achondroplasia
AD, mutation in FGF3 (inhibition of endochondral growth)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

MC lethal form of dwarfism

A

Thantophoric Dysplasia
usual death: Respiratory insufficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MC inherited disorder of the Connective tissue
extreme skeletal fragility due to little bone

A

Osteogenesis imperfecta/Brittle bone dse
Blue sclerae
type I collagen, AD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

morpho: Absence of medullary canal and Erlenmeyer Flask deformity

A

Osteopetrosis/ Marble bone disease
impaired osteoclast function
most AR
Mild autosomal dominant: Albers-Schonberg disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Presence of jigsaw puzzle due to cement lines
mosaic pattern of lamellar bone
elderly, bone pain

A

Paget Disease/ Osteitis Deformans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Bouchard node
Heberden nodes
Osteophytes (Bone spurs)

A

Osteoarthritis
Bouchard node – PIP
Heberden node - DIP
No systemic sx
primarily weight bearing joint

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Triad of Felty Sydrome seen in RA

A

RA
splenomegaly
Neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Skeletal changes in chronic renal failure:
Osteopenia
Osteomalacia
Secondary hyperparathyroidism
Growth retardation

A

Renal Osteodystrophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

most dreaded complication of Pagets dse

A

Osteosarcoma
Fibrosarcoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

fracture healing:
Soft tissue callus/Procallus formation
not yet good for weigh bearing

A

0-2 weeks

17
Q

fracture healing:
Bony callus (Woven bone)

A

2-3 weeks
inc progenitor cells

18
Q

fracture healing:
Lamellar bone

A

3wks - months

19
Q

younger patient’s bone tumor most likely are BENIGN, except

A

Osteosarcoma
Ewing Sarcoma

20
Q

<2cm
Appendicular skeleton - MC: femur
Pain relived by NSAIDs
marked reactive bone formation

A

Osteoid Osteoma
tx: Radiofrequency ablation

21
Q

> 2cm
Axial skeleton
non responsive to NSAIDs

A

Osteoblastoma
tx: En bloc excision

22
Q

<20 y/o
Metaphysis
Codmann triangle
Sunburst appearance
lace-like pattern bone formation

A

Osteosarcoma

23
Q

Bone lesion located in METAPHYSIS

A

Osteosarcoma
Osteochondroma
Chondroma

24
Q

Bone lesion located in EPIPHYSIS

A

Giant cell tumor

25
Q

Bone lesion located in DIAPHYSIS

A

Ewing sarcoma

26
Q

Bone lesion located in AXIAL skeleton

A

Chondrosarcoma
Osteoblastoma

27
Q

MC benign bone tumor
Metaphyseal location

A

Osteochondroma
solitary
loca: knee

28
Q

Spindle hemangiomas and brain gliomas

A

Maffuci syndrome
Seen in Chondroma

29
Q

tumor cells have inc RANKL levels – inc bone resoprtion
Epiphysis located
3rd-5th decade
benign, locally aggressive

A

Giant cell tumor bone/ Osteoclastoma

30
Q

Polyostotic FD + Cafe-au-lait spots + Precocious puberty

A

McCune Albright syndrome

31
Q

Polyostotic FD + Soft tissue myxoma

A

Mazabraud syndrome

32
Q

MC skeletal malignancy

A

Metastasis

33
Q

Autoimmunity, CD4+ T cells and antibodies
small joints of the fingers
+ Pannus
severe chronic inflammation
Swan Neck deformity
Buotonniere deformity

A

Rheumatoid Arthritis
Swan Neck deformity - PIP hyperextension, DIP flexion
Buotonniere deformity - PIP flexion, DIP hyperextension

34
Q

HM of gout

A

Tophi
aggregate of urate crystals surrounded by foreign body giant cells

35
Q

Hyperuricemia
monoarticular joint
1st MTP of big toe
Monosodium urate, needle shape
negatively birefringent (yellow)

A

Gout

36
Q

Pseudogout contents

A

Calcium Pyrophosphate dihydrate
Rhomboid, + birefringent (blue)
Mono/polyarticular
MC involve: knee

37
Q

MC Soft tissue tumor of adulthood

A

Lipoma
encapsulated mass of mature adipocytes

38
Q

MC sarcoma of adulthood

A

Liposarcoma
+ lipoblast

39
Q

mutation in t(12;16)
myxoid with chicken wire vessel scattered round cells and lipoblast

A

Myxoid Liposarcoma

Pathology (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions