Liver, Pancreas Flashcards
acidophilic apoptotic bodies
Councilman bodies
Test of Hepatocyte integrity
ALT AST LDH
Test for Hepatocyte synthetic function
Albumin
PT aPTT
Ammonia
Test of Biliary excretory function
Bilirubin
ALP
gamma - glutamyl transpeptidase
MCC of Portal hypertension
Cirrhosis 85%
Characteristic of Ascites
Serous, <3g/dL protein (mostly albumin)
Serum:ascitic fluid albumin gradient >/1.1g/dL
Hepatitis that can cause severe hepatitis in pregnant
HEV
Hepatitis that is more associated with chronic liver disease
HCV
Hallmark of chronic viral hepatitis
Portal inflammation with fibrosis
Hepatitis C specific findings
CaLaBaSa
Lymphoid follicles
Bile duct injury
Steatosis
Specific findings in Hepatitis B
Ground Glass hepatocytes
inflammatory cells (lymphocyte and plasma cells) within cytoplasm of hepatocytes
Emperipolesis
seen in AI Hepatitis
hepatocellular pattern seen in Drug induced hepatitis
centrizonal necrosis
Diagnosis criteria of NASH
Steatosis
Lobular inflammation
Ballooned hepatocytes
MCC of chronic liver disease in US
Non-alcoholic Fatty Liver disease (NAFLD)
Assoc with Metabolic syndrome
TRIAD of Hemochormatosis
Micronodular cirrhosis
DM
Skin pigmentation
Excessive Iron absorption and deposition into liver and pancreas
AD, impaired Cu excretion into bile and incorporation to Ceruloplasmin
ATP7B mutation Ch13
Movement disorder
Kayser-Fleischer rings
Wilson Disease
inc tissue Cu, Dec serum ceruloplasmin, inc urinary Cu excretion
MC diagnosed inherited hepatic disorder in infants and children
A1 antitrypsin deficiency
AR, MRP2 mutation (impaired transport of non-bile salt organic anions at canalicular membrane)
black liver discoloration
Dubin-Johnson
AR
Impaired STORAGE of conjugated bilirubin in hepatocytes
Rotor syndrome
Charcots TRIAD
Fever
Jaundice
RUQ pain
Cholestatis and paucity of bile ducts
Alagille syndrome
Severe UGT1A1 deficiency
Criggler-Naijar Type 1
this involved in conjugation of bilirubin
Treatment for Extrahepatic biliary atresia
Kasai procedure
Associated conditions Primary Biliary Cholangitis
Sjogren syndrome
Hashimoto thyroditis
Scelroderma
female, + AMA
histo: Florid duct lesion, elongated cirrhotic nodules nodular regenerative hyperplasia
Radiology seen in Primary Sclerosing Cholangitis
Strictures and beading of large bile ducts
assoc. IBD
+ ANCA
onion skin strictures
Sequelae of PBC
Increase risk of HCC
Sequalae of PSC
inc risk of cholangicarcinoma
MCC of small portal vein obstruction
Schistomiasis
Sinusoidal dilation secondary to impaired efflux of hepatic bloody
Peliosis hepatis
liver enlargement, pain and ascites secondary to thrombosis
Budd-Chiari Syndrome
MC benign tumor
Cavernous Hemangioma
MC liver tumor of early childhood
Hepatoblastoma
MC primary malignant tumor
HCC
2nd MC Primary malignant tumor
Cholangiocarcinoma
Nodules/tumor:
obese young women, taking OCP and anabolic steroid
angiography: Hypovascular
Hepatocellular adenoma
assoc with:
OPCa and anabolic steroid
Obese, metabolic syndrome
Adult women
central stellate scar
angiography: Hypervascular wtih dense capillary blush
Focal nodular hyperplasia (vascular lesion)
liver scan: Normal to inc uptake
MC Congenital anomaly of the Gallbladder
folded fundus “Phrygian cap”
mucosal cholesterol-laden macrophages
Cholesterolosis
radiolucent
seen in Cholesterol stone
MC biliary tract disease
Cholelithiasis
RF: forty, female, fat
Calculous
Mononuclear cells in GB
Rokitansky-Aschoff sinuses
Chronic Cholecystitis
notable forms:
Porcelain GB - calcification
Hyalinazing - fibrosing
Xanthogranulomatous cholecystitis
Hydrops
MC pancreatic anomaly
Pancreatic divisum
failure of fusion of fetal pancreatic ducts
congenital anomaly cause by mutation of PDX1 mutation
Agenesis of pancreas
