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Pathology > Liver, Pancreas > Flashcards

Liver, Pancreas Flashcards

1
Q

acidophilic apoptotic bodies

A

Councilman bodies

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2
Q

Test of Hepatocyte integrity

A

ALT AST LDH

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3
Q

Test for Hepatocyte synthetic function

A

Albumin
PT aPTT
Ammonia

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4
Q

Test of Biliary excretory function

A

Bilirubin
ALP
gamma - glutamyl transpeptidase

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5
Q

MCC of Portal hypertension

A

Cirrhosis 85%

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6
Q

Characteristic of Ascites

A

Serous, <3g/dL protein (mostly albumin)
Serum:ascitic fluid albumin gradient >/1.1g/dL

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7
Q

Hepatitis that can cause severe hepatitis in pregnant

A

HEV

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8
Q

Hepatitis that is more associated with chronic liver disease

A

HCV

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9
Q

Hallmark of chronic viral hepatitis

A

Portal inflammation with fibrosis

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10
Q

Hepatitis C specific findings

A

CaLaBaSa

Lymphoid follicles
Bile duct injury
Steatosis

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11
Q

Specific findings in Hepatitis B

A

Ground Glass hepatocytes

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12
Q

inflammatory cells (lymphocyte and plasma cells) within cytoplasm of hepatocytes

A

Emperipolesis
seen in AI Hepatitis

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13
Q

hepatocellular pattern seen in Drug induced hepatitis

A

centrizonal necrosis

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14
Q

Diagnosis criteria of NASH

A

Steatosis
Lobular inflammation
Ballooned hepatocytes

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15
Q

MCC of chronic liver disease in US

A

Non-alcoholic Fatty Liver disease (NAFLD)
Assoc with Metabolic syndrome

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16
Q

TRIAD of Hemochormatosis

A

Micronodular cirrhosis
DM
Skin pigmentation

Excessive Iron absorption and deposition into liver and pancreas

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17
Q

AD, impaired Cu excretion into bile and incorporation to Ceruloplasmin
ATP7B mutation Ch13
Movement disorder
Kayser-Fleischer rings

A

Wilson Disease
inc tissue Cu, Dec serum ceruloplasmin, inc urinary Cu excretion

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18
Q

MC diagnosed inherited hepatic disorder in infants and children

A

A1 antitrypsin deficiency

19
Q

AR, MRP2 mutation (impaired transport of non-bile salt organic anions at canalicular membrane)
black liver discoloration

A

Dubin-Johnson

20
Q

AR
Impaired STORAGE of conjugated bilirubin in hepatocytes

A

Rotor syndrome

21
Q

Charcots TRIAD

A

Fever
Jaundice
RUQ pain

22
Q

Cholestatis and paucity of bile ducts

A

Alagille syndrome

23
Q

Severe UGT1A1 deficiency

A

Criggler-Naijar Type 1
this involved in conjugation of bilirubin

24
Q

Treatment for Extrahepatic biliary atresia

A

Kasai procedure

25
Q

Associated conditions Primary Biliary Cholangitis

A

Sjogren syndrome
Hashimoto thyroditis
Scelroderma

female, + AMA
histo: Florid duct lesion, elongated cirrhotic nodules nodular regenerative hyperplasia

26
Q

Radiology seen in Primary Sclerosing Cholangitis

A

Strictures and beading of large bile ducts

assoc. IBD
+ ANCA
onion skin strictures

27
Q

Sequelae of PBC

A

Increase risk of HCC

28
Q

Sequalae of PSC

A

inc risk of cholangicarcinoma

29
Q

MCC of small portal vein obstruction

A

Schistomiasis

30
Q

Sinusoidal dilation secondary to impaired efflux of hepatic bloody

A

Peliosis hepatis

31
Q

liver enlargement, pain and ascites secondary to thrombosis

A

Budd-Chiari Syndrome

32
Q

MC benign tumor

A

Cavernous Hemangioma

33
Q

MC liver tumor of early childhood

A

Hepatoblastoma

34
Q

MC primary malignant tumor

A

HCC

35
Q

2nd MC Primary malignant tumor

A

Cholangiocarcinoma

36
Q

Nodules/tumor:
obese young women, taking OCP and anabolic steroid
angiography: Hypovascular

A

Hepatocellular adenoma

assoc with:
OPCa and anabolic steroid
Obese, metabolic syndrome

37
Q

Adult women
central stellate scar
angiography: Hypervascular wtih dense capillary blush

A

Focal nodular hyperplasia (vascular lesion)
liver scan: Normal to inc uptake

38
Q

MC Congenital anomaly of the Gallbladder

A

folded fundus “Phrygian cap”

39
Q

mucosal cholesterol-laden macrophages

A

Cholesterolosis
radiolucent
seen in Cholesterol stone

40
Q

MC biliary tract disease

A

Cholelithiasis
RF: forty, female, fat

41
Q

Calculous
Mononuclear cells in GB
Rokitansky-Aschoff sinuses

A

Chronic Cholecystitis

notable forms:
Porcelain GB - calcification
Hyalinazing - fibrosing
Xanthogranulomatous cholecystitis
Hydrops

42
Q

MC pancreatic anomaly

A

Pancreatic divisum
failure of fusion of fetal pancreatic ducts

43
Q

congenital anomaly cause by mutation of PDX1 mutation

A

Agenesis of pancreas

Pathology (18 decks)

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