Breast

Question 1

MC and deadly malignancy of women globally

Answer 1

Breast Carcinoma

Question 2

Lifetime exposure to estrogen

Answer 2

Nulliparity
Early menarche
Late menopause
Primiparity at >35 y/o

Question 3

BRCA1 Ch17 more associated with

Answer 3

Ovarian malignancy

Question 4

BRCA2 Ch13 associated with

Answer 4

Male breast Cancer
may be ER positive

Question 5

it encodes E-cadherin

Answer 5

CDH1 Ch16
loss of expression is seen in ALH, LCIS, ILC

Question 6

treatment for Luminal A and B (ER+, HER-)

Answer 6

Tamoxifen

Question 7

Treatment for HER2+

Answer 7

Transtuzumab

Question 8

treatment for triple negative breast Ca

Answer 8

Chemotherapy
Immunotherapy PD-L1 inhibitors

Question 9

malignant epithelial cells within ducts
+ mass (periductal fibrosis)
mammography: Calcifications
mild-severe nuclear atypia

Answer 9

Ductal Carcinoma in situ

Question 10

Discohesive growth of malignant cells due to E-cadherin loss
monomorphic with mild atypia

Answer 10

LCIS

Question 11

MC type Carcinoma

Answer 11

Invasive BCa
hard mass – prominent desmoplasia

Question 12

MC benign tumor of the female breast

Answer 12

Fibroadenoma
proliferation of stromal and epithelial elements
smaller lesion
younger women

Question 13

stromal > epithelial component
leaf like stromal projections
well circumscribed to infiltrative
older women

Answer 13

Phyllodes tumor