SKELETAL SYSTEM (SIMPLIFIED) Flashcards
Functions of skeletal system
- Support
- Movement
- Protection
- Mineral storage
- Energy storage
- Hematopoiesis
Support
Bones and cartilage support rest of body
Movement
Bones facilitate movement by serving as points of attachment for muscles and act as levers
Protection
Bones protect internal organs from injury by covering them (eg. Ribs protect lungs and heart, vertebrae protect spinal cord, skull protect brain)
Mineral storage
Bone acts as a reservoir for some minerals important for body function such as calcium and phosphorus that can be released back to bloodstream to maintain level needed for physiological processes
Energy storage
Bone marrow in softer connective tissues that fills interior of bone contains yellow bone marrow which has adipose tissue and the triglycerides here serve as energy storage
Hematopoiesis
RBC, WBC, platelet production occurs in red marrow
Bone classification
- Long
- Short
- Flat
- Irregular
- Sesamoid
Long (3)
- Cylinder shape
- Functions as leverage
- Tibia, fibula, metatarsals, metacarpals, phalanges, ulna, humerus, radius)
Short (3)
- Cube like shape equal in width, length thickness
- Functions in providing stability, support and allow motion
- Carpals, tarsals
Flat (3)
- Thin and curved
- Functions as points of attachments for muscles and protects internal organs
- Sternum, rib, scapulae, cranial bone
Irregular (3)
- Complex shapes
- Functions in protecting internal organs
- Vertebrae, facial bones
Sesamoid (3)
- Small and rounded, embedded with tendons
- Functions in protecting tendons from compressive forces
- Patallae
Diaphysis
Tubular shaft running between proximal and distal end of bone containing hollow regions called medullary cavity filled with yellow marrow
Epiphysis
Wider section at each end of bone filled with spongy bone with spaces filled with red marrow
Metaphysis
Where epiphysis and diaphysis meet that contains epiphyseal plate (layer of hyaline cartilage in growing bone)
Epiphyseal line
Indicator of boundary between epiphysis and diaphysis and becomes epiphyseal plate when bone is matured, and the cartilage layer is replaced by osseous tissue
Endosteum
Delicate membranous lining in medullary cavity where bone growth, repair, and remodelling occur
Periosteum
Fibrous membrane covering the outer surface of bone (except where epiphyses meet) containing blood vessels, nerves, and lymphatic vessels that nourish compact bone
Articular cartilage
Thin layer of cartilage that covers epiphyses to reduce friction and absorb shock
4 types bone cells
- Osteocyte
- Osteoblast
- Osteogenic cell
- Osteoclast
Osteocyte
A mature and the most common bone cell that results from when a trapped osteoblast changes in structure and becomes osteocyte; MAINTAINS BONE MATRIX AND LIVES IN LACUNAE
Osteoblast
Responsible for forming new bones found in growing portions of bone, including periosteum and endosteum; Secretes organic compounds of matrix
Osteogenic cell
Undifferentiated cells that develop into osteoblasts
Osteoclast
Found on bone surface for bone resorption, multinucleated, and originate from 2 types of WBC and not osteogenic cell; SECRETE ACID AND ENZYMES TO DISSOLVE BONE MATRIX
Osteon
Structural unit of compact bone composed of concentric rings of calcified matrix called lamellae
Central canal
Center of osteon containing blood vessels, nerves, and lymphatic vessels that branch off
Canaliculi
Small lines (ducts) in osteon that connect with caniculli of other lacunae and eventually with central canal. Allows nutrients to be transported to osteocytes and wastes removed
Nutrient arteries
Pass through nutrient foramen (small opening in diaphysis) that nourish the spongy bone and medullary cavity
How are osteocytes in spongy bone nourished
Blood vessels of the periosteum that penetrate spongy bone and blood that circulate in marrow cavities
Embryonic skeleton
Consists of only fibrous membranes and hyaline cartilage. By week 6 or 7 of development, ossification (formation of bones begins)
Intramembranous ossification vs endochondral ossification
- Intramembranous: Bone develops directly from sheets of mesenchymal connective tissue; occurs in flat bones of face, cranial bones, clavicles
- Endochondral: Bone develops by replacing hyaline cartilage; occurs on base of skull long bones
- Endochondral takes longer than intramembranous
7 Steps of intramembranous ossification
- Mesenchymal cells differentiate into specialized cells (osteogenic cells and capillary forming cells)
- Osteoblasts form clusters called ossification centers
- Osteoblasts secrete osteoid which calcifies and traps osteoblasts and transforming them into osteocytes
- Surrounding osteogenic cells differentiate into new osteoblasts
- Osteoid secretion around capillaries forms trabecular matrix, and osteoblasts on surface become periosteum
- Periosteum forms protective layer of compact bone
- Trabecular bone crowds nearby blood vessels which condense into red marrow
9 steps of endochondral ossification:
- Mesenchymal cells differentiate into chondrocytes that form cartilaginous skeletal precursor
- Perichondrium appears and chondrocytes in center grow in size
- Matrix calcifies, leading to chondrocyte death and disintegration of surrounding cartilage
- Blood vessels invade spaces, enlarging them and carrying osteogenic cells
- Space combines to form medullary cavity and capillaries penetrate cartilage
- Perichondrium transforms into periosteum and periosteal collar of compact bone forms around cartilage
- Primary ossification center forms deep in periosteal collar
- Similar events occur in secondary ossification centers in epiphyseal regions
- Cartilage remains at joint surfaces as articular cartilage and between diaphysis and epiphysis as growth plate responsible for bone lengthening
Growth plate zones (4):
- Reserve zone
- Proliferative zone
- Maturation and hypertrophy zone
- Calcified zone
Reserve zone (2)
- Closest to epiphysis consisting of resting chondrocytes that anchor the growth plate to bone
- Chondrocytes dont participate in bone growth but only secure growth plate to osseous tissue
Proliferative zone
Chondrocytes undergo rapid cell division leading to formation of new chondrocytes