Sjrogens Flashcards
Dry eyes and dry mouth is known as?
Sicca syndrome.
T/Fsjrogen is an autoimmune syndrome? Which cells are involved?
T
Lymphocyte medited destruction starting with B cells then T clls
Dry eyes dry mouth and othe CTD is known as?
Secondary sjorgen
Which is more common primary or secondary sjorgens?
Secondary
Which CTD are commonly associated with Srojgen?
RA most common
SLE
Polymyositis
Scleroderma least common
What are the predisposing factors to sjorgen?
Genetic basis
Sjorgen Like syndrome seen in HIV, Hep C, EBV and GvHD
Which exocrine glands are most commonly affected ?
Vaginal
Salivary
Lacrimal
Which autoantibodies are most commonly seen in Sjtogrns?
RF: IgG against IgM
SSA: Ro
SSB: R la
What are the oral complication of sjorgen?
Caries Unpleasant taste Candida Ascending suppurative sialadenitis Salivary gland enlargement Burning Malodour Cracker sign (difficult eatingdry food)
What are the eye signs of sjorgens?
Foriegn body sensation
Inability to produce tears
Light intolerance
People that have secondary sjorgens, which precedes, the CTD or the dry eyes and moth?
CTD
What are the association of SS?
Automoimmine thyroid disease
Primary biliary cirrhosis
B cell lymphoma
What investigations would you do in sjorgens?
Bloods: SSA SSB, igA, RF
HIV, HEP C,
Saliva flow test
Labial gland biopsy: focal lymphocytic infiltrate, acinar atrophy, fibrosis
Schirmer test : sterile blotting paper inserted into conjunctival fornix and measure tear less than or equal to 5mm/5 min is reduced
T/F there is both cellular and humorwl immunity involve in sjorgens?
T
What are the general symptoms of sjorgens?
Fatigue
Muscle pain
Arthralgia
