Self/Non Self Differentiation Flashcards
What are the main ways of developing tolerance?
- Deletion
Anergy
Ignorance
Regulate
No T cell is autoreactive as if they were there would be autoinmune disease developing T/F
F, all T cells are somewhat immune, as they require low level TCR stimulation for survival, but they do not have the necessary co-stimulation to initiate disease
What type of tolerance B or T is more efficient?
T, b torerance heavy relays of T tolerance being the best possible
Where does T and B cell tolerance occur?
T -> Thymus
B -> Bone Marrow
What happens if a B cell binds to a self-cellular target during development?
there is crosslinking of the bound IgM and this would lead to apoptosis
What happens if a B cell binds to a self-soluble target during development?
Depending on strength of binding there would be anergy (crosslinking) or ignorance (no-crosslinking)
What is required for the development of a B cell response?
Ig-Ag recognition
Cd-40L (on T cell)
Cytokines
If there is no reaction with CD40L on T cells what happens to the B cell?
Anergy
If there is reaction with CD40L on T cells what happens to the B cell?
Isotype switching
Memory development
What type of thymocyte undergoes positive and negative selection?
Double positive CD4+ and CD8+
What are positive and Negative selection which one comes first?
Positive: if thymocyte does not bind self antigen they die
Negative: if thymocyte binds self-antigen too strongly they die
What molecule related to development of tolerance is produced in the thymus and what does it do?
AIRE (Autoinmmune Regulator of Expression)
activates the transcription of peripheral antigens in order for them to be expressed in the thymus
Can sometimes cause thymus cell death in order for DC to show antigen on MHC II
Where is AIRE expressed?
Medullary Epithelial Cells
If during T cell tolerance they thymocyte binds a bit too strongly but not enough to cause death what is the result?
Development of Tregs
What is required for T cell inmmunity and activation?
TCR + Antigen+MHC
CD28- CD80/86 (on DC) interaction
Cytokines
