Chemical Transmission in the CNS

Question 1

Pathway for neurotransmission

Answer 1

Synthesis and Storage - Release - Receptor Activation - Inactivation

Question 2

What does cocaine block?

Answer 2

Neuronal Uptake Transporter

Dopamine * ,NA, Serotonin*

Question 3

How does amphetamine act?

Answer 3

Indirectly acting sympathomimetic

Question 4

What is the main mechanism of inactivation of NA?

Answer 4

Neuronal Uptake (95%)

Question 5

Tyrosine —-1–> L Hydroxyphenylalanine
L Hydroxyphenylalanine —2—> Dopamine
Dopamine —3—> Noradrenaline

Answer 5

1 Tyrosine Hydroxilase
2 Dopa Decarboxylase
3 Dopamine ß-hydroxylase

Question 6

in the adrenal glands there is transformation of NA to Adrenalin thanks to the enzyme

Answer 6

Phenyl-ethanodamine-N-Metyl-Transferase

Question 7

NA is synthesised in the cytoplasm of the cell T/F

Answer 7

F, in the vesicles

Question 8

too little dopamine in the basal ganglia

Answer 8

Parkinson’s Disease

Question 9

too little dopamine in the basal ganglia, prefrontal cortex, and temporal lobe

Answer 9

Schizophrenia

Question 10

too little dopamine in the nucleus accumbens and ventral tegmental areas

Answer 10

Dependence and addiction

Question 11

too little dopamine in the pituitary

Answer 11

prolactin secretion

Question 12

Another action of cocaine is

Answer 12

analgesic (blocks Na+ channels)

effects more strongly dopamine pathways causing adiction

Question 13

Ligand Gated Receptor

Answer 13

Nicotinic+

Gaba A-

Question 14

G Protein Coupled Receptor

Answer 14

Muscarinic, Adrenoreceptors

Question 15

Types of receptors

Answer 15

Ligand Gated Receptor
G Protein Coupled Receptor
Tyrosine Kinase
Cytoplasmatic/Nuclear