Hearing Flashcards

1
Q

what is the pathway sound must travel by to reach the oval window?

A

Tympanic Membrane - Malleus - Incus - Stapes - Oval Wndow

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2
Q

What is the ratio Tympanic Membrane : Oval Window

A

the first is 20x bigger thus there is an amplification of the wave

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3
Q

What are the subdivisions of the cochlea?

A

Scala Vestibuli
Scala Media
Scala Tympani

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4
Q

Where is the basilar membrane found?

A

between the scala media and scala tympani

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5
Q

What is tonotopia?

A

the coding of different information by the basilar membrane depending on the frequency of the sound

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6
Q

What area of the basilar membrane codes for higher frequencies?

A

the stiffer part: the base (close to the oval window)

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7
Q

What area of the basilar membrane codes for lower frequencies?

A

the less stiff part: the apex (away from oval window)

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8
Q

what type of cells code for sound and where are they found?

A

Hair Cells

on the basilar membrane

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9
Q

what is at the top of the hair cells?

A

Stereocillia

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10
Q

What type of hair cells can be damaged by aspirin or gentomycin or other ototoxic compunds? and what is the result of the damage?

A

Outer hair cells

Loss of hearing

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11
Q

Where does the efferent signal for the outer hair cells come from?

A

Superior Olivary Complex

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12
Q

What do inner hair cells do?

A

Sound coding

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13
Q

What are the stereocillia of the outer hair cells attaching to?

A

the tectorial membrane

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14
Q

What is the function of the outer hair cells?

A

increase movement of the basilar membrane when low intensity waves reach the cochlea
depolarisation causes contraction

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15
Q

What type of channels sit at the top of the inner hair cells? how are they activated?

A

K+ channels

Mechanically Activated

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16
Q

What is the Kinocillium?

A

tallest sterocillia at the top of the inner hair cell

17
Q

Movement towards the Kinocillium causes 1

Movement away from the Kinocillium causes 2

A
1 Depolarisation (Always bigger)
2 Hyperpolarisation
18
Q

activation of the inner hair cells causes the release of the neurotransmitter….

A

Glutamate

19
Q

Which scala is filled with high [k+]

A

scala media

20
Q

How is K recycled for activation of the inner hair cells?

A

thanks to K channels between the scala media and the scala tympani

21
Q

what is the middle ear’s function?

A

impedance matching, without it all the sound would just bounce back

22
Q

Where does the information of the auditory pathway is integrated?

A

Superior Olivary Complex

23
Q

Where is the cell body of the CN8?

A

Spiral Ganglion within the chochlea

24
Q

The nerve cells of CN8 are bipolar T/F

A

T

25
Q

The information that reaches each Superior Olivary Complex comes from one ear only

A

F, information comes from both

26
Q

Where is the nucleus of CN8?

A

Pons

27
Q

in which lobe is the auditory cortex?

A

Temporal Lobe

28
Q

Information from the Superior Olivary Complex travels via

A

the lateral lemniscus

29
Q

what midbrain structure connects the lateral lemniscus of the pons with the Medial Geniculate Nucleus of the thalamus

A

the inferior colliculus

30
Q

What is the Medial Geniculate Nucleus (MGN) related to

A

Hearing

31
Q

in the cortex of the brain is there asymmetrical representation of complex sounds? if so how it it divided?

A

Speech-> left

Music -> Right

32
Q

the auditory cortex is tonotropic (T/F) and receives information from one ear only (T/F)

A

T

F

33
Q

What is the pathway for sound signalling?

A

Inner Hair Cells - CN8 (Spiral Ganglion) - Chochlear Nuclei - Superior Olive (x2) - Lateral Lemniscus - Inferior Colliculus - Medial Geniculate Nucleus - Auditory Cortex

34
Q

At what site do we determine where is sound coming from?

A

Superior Olivary Complex

35
Q

The medial superior olive localises time depending on… (1)… and this is the most relevant form for —-2–

A

1 Time Delay

2 Low frequencies

36
Q

Time Delay analysis of sound depends on

A

more neurons are activated by the ear where the sound is closer to

37
Q

Localising sound by intensity differences happens in

A

Lateral Superior Olive and Medial Nucleus of Trapezius Body

38
Q

Localising sound by intensity differences is more relevant for

A

Higher Frequencies

39
Q

What is the process of Localising sound by intensity differences

A

1 one nuclei gets activated more than the other
2 lateral superior olive sends excitatory signal to ipsilateral Medial Nucleus of Trapezius Body which then sends inhibitory signal to contralateral lateral superior olive
3 Both lateral superior olives send signals to the higher centres but one is going to be stronger than the other due to more inhibition from Medial Nucleus of Trapezius Body