DeMenTIa Flashcards
What are the main chromosomes linked to Alzheimer’s Disease?
1*
14*
19
21* *= Early onset
what is the main cause of Alzheimer’s Disease?
Cleavage of the transmembrane protein APP (Amyloid Precursor Protein) and deposition of plaques
What are the main enzymes involved in development of the plaques?
ßSecretase (forms N terminal that causes aggregation)
¥Secretase (cuts closer to membrane)
What are the main types of Alzheimer’s Disease?
Frontal
Visuospatial
Amnestic
Aphasic
What does Aß protein deposition and plaque formation cause?
disruption of the synapse, transmission and this leads to cell death
What is Metal Proteins Attenuating Compound (MPAC)?
Possible treatment that has causes improvement of symptoms and clearing of the plaques in animal models
From normal to Alzheimer’s Disease how many years does it take? and from pre-Alzheimer’s Disease
~ 30
~ 20
Bovine Spongiform Encephalitis is given this name because?
there is loss of neurons in small clusters giving it the appearance of a sponge
How do neurons look histologically in Bovine Spongiform Encephalitis?
Fluid filled vacuoles in axon with activation of astrocytes
Bovine Spongiform Encephalitis in humans is called?
variable Creutzfeldt–Jakob disease
What is the cause of Spongiform Encephalitis?
Prions (miss folded proteins) that are able to make normal proteins miss-fold
What does the prion in Creutzfeldt–Jakob disease causes?
Up-regulates ßsheet production and autocatalysis
What is the onset and time of death for vCJD?
26-28
What is the onset for sCJD?
50-68
Why do people think that another peak of CJD is soon to happen in 2020?
because of blood transmission as the prion can be found in the tonsils and muscle of humans
