Sedative-Hypnotics, Alcohols

Question 1

Benzodiazepine that is good for initiation and maintenance of sleep

Answer 1

Short acting benzodiazepines

Question 2

Most feared side effect of sedative hypotic drugs

Answer 2

Respiratory depression

Question 3

Benzodiazepine that binds GABA A receptor subunits

Used for anesthesia induction and preoperative sedation

Answer 3

Midazolam

Question 4

Midazolan can cause this type of amnesia

Answer 4

Anterograde

Question 5

Intermediate acting benzodiazepine that binds to GABA A receptor used for anxiety, seizure disorders, tranquilizer and status epilepticus

Answer 5

Lorazepam, alprazolam, clonazepam

Question 6

What abnormal sleep pattern results from the use of benzodiazepines?

Answer 6

Decreased REM sleep

Question 7

What are the Long acting benzodiazepines

Answer 7

Diazepam
Flurazepam
Chlorazepate
Chlordiazepoxide
Flunitrazepam

Question 8

This long acting benzodiazepine is used as a date rape drug

Answer 8

Flunitrazepam

Question 9

Longest half life benzodiazepine

Answer 9

Chlordiazepoxide (36-200 hours)

Question 10

Antidote for benzodiazepines

Answer 10

Flumazenil

Question 11

Ultra short acting barbiturate that is used for anesthesia induction and increased ICP

Answer 11

Thiopental
Thiamylal
Methohexital

Question 12

Short and intermediate acting barbiturates used for insomnia and preoperative sedation, antiseizure

Answer 12

Pentobarbital
Seco
Amo
Butalbital
Buta
Talbutal
Apro

Question 13

Barbiturates are potent ______ of CYP450 enzymes

Answer 13

Inducers

Question 14

Long acting barbiturates used for status epilepticus, hyperbilirubinemias, Gilbert syndrome

Answer 14

Phenobarbital
Mephobarbital
Primidone

Question 15

Enzyme deficient in acute intermittent porphyria

Answer 15

HMB synthase

Question 16

What is the most catastrophic symptom of sedative hypnotic withdrawal

Answer 16

Rebound suicide

Question 17

Newer hypnotic that binds selectively to a subgroup in GABA A
Used for insomnia only

Answer 17

Zolpidem
Zaleplon
Eszopiclone

Question 18

Anxiolytic that is a partial agonist at 5HT1a that is used for generalized anxiety disorder

Answer 18

Buspirone

Question 19

Drugs that Cause disulfiram reaction

Clara took the Pre-Medical Test in the PM

Answer 19

Chlorpropamide
Cefoperazone
Cefomandole
Cefotetan
Procarbazine
Metronidazole

Question 20

Responsible for ethanol metabolism at blood levels higher than 100 mg/dL

Answer 20

Microsomal Ethanol Oxidizing System

Question 21

Impairment of driving ability is at this blood alcohol level

Answer 21

60-8g/dL

Question 22

Blood alcohol concentration where there is impaired motor function, slurred speech, ataxia

Answer 22

100-200mg/dL

Question 23

Most common complication of chronic alcohol abuse

Answer 23

Liver disease

Question 24

Most common neurologic abnormality in chronic alcoholics

Answer 24

Peripheral neuropathy

Question 25

Symptoms of Wernicke-Korsakoff syndrome

Answer 25

Weird ACO

Ataxia
Confusion
Ophthalmoplegia

Question 26

How much ethanol per day may protect against CAD?

Answer 26

10-15g/day

Question 27

This vitamin protects against Wernicke Korsakoff

Answer 27

Thiamine

Question 28

Symptoms of delirium tremens

HAD-48

Answer 28

Hallucinations
Autonomic instability
Delirium
48-72 post discontinuation

Question 29

DOC for alcohol withdrawal syndrome

Answer 29

Long acting benzodiazepine

Question 30

DOC for ethylene glycol poisoning

Answer 30

Fomepizole