Sedative-Hypnotics, Alcohols Flashcards

1
Q

Benzodiazepine that is good for initiation and maintenance of sleep

A

Short acting benzodiazepines

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2
Q

Most feared side effect of sedative hypotic drugs

A

Respiratory depression

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3
Q

Benzodiazepine that binds GABA A receptor subunits

Used for anesthesia induction and preoperative sedation

A

Midazolam

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4
Q

Midazolan can cause this type of amnesia

A

Anterograde

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5
Q

Intermediate acting benzodiazepine that binds to GABA A receptor used for anxiety, seizure disorders, tranquilizer and status epilepticus

A

Lorazepam, alprazolam, clonazepam

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6
Q

What abnormal sleep pattern results from the use of benzodiazepines?

A

Decreased REM sleep

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7
Q

What are the Long acting benzodiazepines

A
Diazepam
Flurazepam
Chlorazepate
Chlordiazepoxide
Flunitrazepam
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8
Q

This long acting benzodiazepine is used as a date rape drug

A

Flunitrazepam

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9
Q

Longest half life benzodiazepine

A

Chlordiazepoxide (36-200 hours)

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10
Q

Antidote for benzodiazepines

A

Flumazenil

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11
Q

Ultra short acting barbiturate that is used for anesthesia induction and increased ICP

A

Thiopental
Thiamylal
Methohexital

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12
Q

Short and intermediate acting barbiturates used for insomnia and preoperative sedation, antiseizure

A
Pentobarbital
Seco
Amo
Butalbital
Buta
Talbutal
Apro
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13
Q

Barbiturates are potent ______ of CYP450 enzymes

A

Inducers

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14
Q

Long acting barbiturates used for status epilepticus, hyperbilirubinemias, Gilbert syndrome

A

Phenobarbital
Mephobarbital
Primidone

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15
Q

Enzyme deficient in acute intermittent porphyria

A

HMB synthase

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16
Q

What is the most catastrophic symptom of sedative hypnotic withdrawal

A

Rebound suicide

17
Q

Newer hypnotic that binds selectively to a subgroup in GABA A
Used for insomnia only

A

Zolpidem
Zaleplon
Eszopiclone

18
Q

Anxiolytic that is a partial agonist at 5HT1a that is used for generalized anxiety disorder

19
Q

Drugs that Cause disulfiram reaction

Clara took the Pre-Medical Test in the PM

A
Chlorpropamide
Cefoperazone
Cefomandole
Cefotetan
Procarbazine
Metronidazole
20
Q

Responsible for ethanol metabolism at blood levels higher than 100 mg/dL

A

Microsomal Ethanol Oxidizing System

21
Q

Impairment of driving ability is at this blood alcohol level

22
Q

Blood alcohol concentration where there is impaired motor function, slurred speech, ataxia

A

100-200mg/dL

23
Q

Most common complication of chronic alcohol abuse

A

Liver disease

24
Q

Most common neurologic abnormality in chronic alcoholics

A

Peripheral neuropathy

25
Symptoms of Wernicke-Korsakoff syndrome
Weird ACO Ataxia Confusion Ophthalmoplegia
26
How much ethanol per day may protect against CAD?
10-15g/day
27
This vitamin protects against Wernicke Korsakoff
Thiamine
28
Symptoms of delirium tremens HAD-48
Hallucinations Autonomic instability Delirium 48-72 post discontinuation
29
DOC for alcohol withdrawal syndrome
Long acting benzodiazepine
30
DOC for ethylene glycol poisoning
Fomepizole