Sedative-Hypnotics, Alcohols Flashcards
Benzodiazepine that is good for initiation and maintenance of sleep
Short acting benzodiazepines
Most feared side effect of sedative hypotic drugs
Respiratory depression
Benzodiazepine that binds GABA A receptor subunits
Used for anesthesia induction and preoperative sedation
Midazolam
Midazolan can cause this type of amnesia
Anterograde
Intermediate acting benzodiazepine that binds to GABA A receptor used for anxiety, seizure disorders, tranquilizer and status epilepticus
Lorazepam, alprazolam, clonazepam
What abnormal sleep pattern results from the use of benzodiazepines?
Decreased REM sleep
What are the Long acting benzodiazepines
Diazepam Flurazepam Chlorazepate Chlordiazepoxide Flunitrazepam
This long acting benzodiazepine is used as a date rape drug
Flunitrazepam
Longest half life benzodiazepine
Chlordiazepoxide (36-200 hours)
Antidote for benzodiazepines
Flumazenil
Ultra short acting barbiturate that is used for anesthesia induction and increased ICP
Thiopental
Thiamylal
Methohexital
Short and intermediate acting barbiturates used for insomnia and preoperative sedation, antiseizure
Pentobarbital Seco Amo Butalbital Buta Talbutal Apro
Barbiturates are potent ______ of CYP450 enzymes
Inducers
Long acting barbiturates used for status epilepticus, hyperbilirubinemias, Gilbert syndrome
Phenobarbital
Mephobarbital
Primidone
Enzyme deficient in acute intermittent porphyria
HMB synthase
What is the most catastrophic symptom of sedative hypnotic withdrawal
Rebound suicide
Newer hypnotic that binds selectively to a subgroup in GABA A
Used for insomnia only
Zolpidem
Zaleplon
Eszopiclone
Anxiolytic that is a partial agonist at 5HT1a that is used for generalized anxiety disorder
Buspirone
Drugs that Cause disulfiram reaction
Clara took the Pre-Medical Test in the PM
Chlorpropamide Cefoperazone Cefomandole Cefotetan Procarbazine Metronidazole
Responsible for ethanol metabolism at blood levels higher than 100 mg/dL
Microsomal Ethanol Oxidizing System
Impairment of driving ability is at this blood alcohol level
60-8g/dL
Blood alcohol concentration where there is impaired motor function, slurred speech, ataxia
100-200mg/dL
Most common complication of chronic alcohol abuse
Liver disease
Most common neurologic abnormality in chronic alcoholics
Peripheral neuropathy
Symptoms of Wernicke-Korsakoff syndrome
Weird ACO
Ataxia
Confusion
Ophthalmoplegia
How much ethanol per day may protect against CAD?
10-15g/day
This vitamin protects against Wernicke Korsakoff
Thiamine
Symptoms of delirium tremens
HAD-48
Hallucinations
Autonomic instability
Delirium
48-72 post discontinuation
DOC for alcohol withdrawal syndrome
Long acting benzodiazepine
DOC for ethylene glycol poisoning
Fomepizole
