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Pharma > Parkinsonism, Psych, Opioids, Abuse > Flashcards

Parkinsonism, Psych, Opioids, Abuse Flashcards

1
Q

Primary drug for Parkinsonism

A

Levodopa Carbidopa

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2
Q

Levodopa is contraindicated in patients with a history of

A

Psychosis

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3
Q

Phenomenon in Parkinson wherr there is alternating periods of inproved mobility and akinesia over a few hours or days during the treatment

A

On- Off Phenomena

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4
Q

Phenomenon in Parkinson where there is deterioration of drug effect in between doses

Due to progressive destruction of nigrostriatal neurons that occur with disease progression

A

Wearing off Phenomenon

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5
Q

Partial agonist at dopamine D2 receptors in thr brain

Used in Parkinson, Levodopda intolerance and hyperprolactinemia

Can cause erythromelalgia

A

Bromocriptine

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6
Q

Antiparkinsonism that is a partial agonist at D3 receptors

Compulsive gambling, hypersexuality overeating

A

Pramipexole

Ropinirole

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7
Q

Antiparkinsonism drug that is a partial D3 agonist

Used for off periods of Parkinsonism

Severe nausea

A

Apomorphine

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8
Q

Patients who are taking apomorphine should take this drug first to prevent severe nausea

A

Trimethobenzamide

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9
Q

Antiparkinsonism drug that partially inhibits MAO B at a certain dose

Can cause serotonin syndrome when used with SSRI TCA Meperidine

A

Selegiline

Rasagiline

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10
Q

COMT inhibitor that blocks L-dopa metabolism and prolongs response to levodopa

Orange urine
Hepatotoxic
Neuroleptic malignant syndrome
Rhabdomyolysis

A

Entacapone

Tolcapone

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11
Q

Drug used to potentiate dopaminergic action

Can cause livedo reticularis

A

Amantadine

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12
Q

Drugs that can cause livedo reticularis

A MAN reads fHM and GQ

A 
Amantadine
Hydroxyurea
Minocycline
Gemcitabine
Quinidine
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13
Q

Anticholinergic drug used for Parkinsons that blocks muscarinic receptors

Used to prevent EPS caused by antipsychotics
Little effect on bradykinesia

A 
Benztropine 
Biperiden 
Trihexyphenidyl 
Orphenadine
Procyclidine
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14
Q

This drug is effective in some schizophrenic patients resistant to treatment with other antipsychotics

A

Clozapine

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15
Q

Dopaminergic tract for mentation and mood

A

Mesocortical-Mesolimbic

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16
Q

Dopaminergic tract for extrapyramidal function

A

Nigrostriatal

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17
Q

Dopaminergic tract for control of prolactin release

A

Tuberoinfundibular

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18
Q

Irreversible disorder characterized by repetitive involuntary movements like tongue protrusion and lip smacking

A

Tardive dyskinesia

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19
Q

Typical antipsychotic that blocks D2 receptors

EPS, failure of ejculation, corneal and lens deposits, NMS

A

Chlorpromazine

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20
Q

Only antipsychotic with fatal overdose

Strongest autonomic effects

A

Thioridazine
Fluphenazine
Perphenazine

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21
Q

Typical antipsychotic used for schizophrenia, manic phase of bipolar, Huntington and Tourette

Weakest autonomic effects
Less sedating

A

Haloperidol

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22
Q

Atypical antipsychotic used for refractory schizophrenia

Only antipsychotic that reduces risk of suicide

A

Clozapine

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23
Q

Antipsychotic than can cause agranulocytosis

A

Clozapine

Watch clozely for agranulocytosis

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24
Q

Atypical antipsychotic that can cause weight gain

A

Olanzapine= Obesity

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25
Q

Most sedating atypical antipsychotic

A

Quetiapine= Quiet- apine

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26
Q

Atypical antipsychotic less sedating than quetiapine

Hyperprolactinemia

A

Risperidone

Rise and Shine
Rise to a pair

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27
Q

Only antipsychotic approved for schizophrenia in the youth

A

Risperidone

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28
Q

Atypical antipsychotic that can cause postural hypotension, QT prolongation

A

Ziprasidone

29
Q

Least sedating atypical antipsychotic

A

Aripiprazole

30
Q

Features of Neuroleptic Malignant Syndrome

A 
FEVER
Fever
Encephalopathy 
Vitals unstable
Elevated CPK
Rigidity
31
Q

Threshold for lithium toxicity

A

2 meq/L

32
Q

Treatment for lithium overdose

A

Dialysis

33
Q

Neurotransmitters involved in the expression of mood

A

NE

Serotonin

34
Q

Antidepressant ( TCA) used for enuresis and MDD not responsive to other drugs

A

Imipramine

IHI-pramine

35
Q

3 Cs of TCA toxicity

A

Cardiotoxicity
Convulsions
Coma

36
Q

TCAs mode of action is the blocksde of which transporters?

A

NE and 5HT

ANS and histamine

37
Q

First line for MDD

A 
Fluoxetine
Paroxitine
Citalopram
Escitalopram
Sertraline
Vilazodone
38
Q

SSRIs can cause serotonin syndrome when used with what drug?

A

MAOIs

39
Q

SSRI approved only for OCD

A

Fluvoxamine

40
Q

SSRI that can cause diarrhea

A

Sertraline

Squirtraline

41
Q

Drugs that can cause erectile dysfunction

A

A SORE PeniS can’t Fuck Hard

SSRI
Opiates
Risperidone 
Ethanol, Estrogen
Propranolol 
Spironolactone
Finasteride
Hydrochlorothiazide
42
Q

Drugs that can cause priapism

A

Tigas PeniS Qo, AyaW Bumaba

Trazodone
Papaverine
Sildenafil
Quetiapine 
Alprostadil
Warfarin
Bupropion
43
Q

Tetracyclic antidepressant used for major depression

A

Mirtazapine

44
Q

Tetracyclic antidepressant that inhibits neuronal reuptake of dopamine and NE

Used for smoking cessation

A

Bupropion

45
Q

MAOI (Phenelzine) can cause hypertensive crisis when taken with

A

Tyramine

46
Q

Treatment for NMS

A

Diphenhydramine

47
Q

Opioid with shortest half life

A

Remifentanil (3-4 mins)

48
Q

Opioid with longest half life

A

Buprenorphine ( 4-8 hours)

49
Q

Opioid analgesic against mu receptors

Used for severe pain and adjunct for anesthesia

A

Morphine

50
Q

Antidote for morphine

A

Naloxone

51
Q

Opioid that is a strong agonist against mu receptors. Inhibits pain at spinal and supraspinal sites

Used in severe pain, chronic pain, cancer pain

A

Fentanyl

52
Q

Most potent opioid

A

Ohmefentanyl

53
Q

Strong opioid agonist at mu and kappa receptors

Used for spasmodic pain

A

Meperidine

54
Q

Strong opioid agonist at mu receptors

Used for opioid dependence and withdrawal

A

Methadone

55
Q

Partial opioid agonist at mu and kappa receptors used for chronic, neuropathic and cancer pain

Can cause hypogonadism, hearing loss

A

Hydrocodone

Oxycodone

56
Q

Partial opioid agonist used for cough suppression

A

Dextrometorphan

Codeine

57
Q

Weak agonist at mu receptors used for mild to moderate pain and restless legs syndrome

Withdrawn because of fatal cardiotoxicity
Commonly used in suicide

A

Propoxyphene

58
Q

Mixed opioid agonist-antagonist

Strong agonist at kappa and weak antagonist at mu receptors

Used for alcohol dependence

A

Nalbuphine

59
Q

Dual acting opioid analgesic
Weak agonist at mu receptors for moderate pain

Lowers seizure threshold, nausea and vomiting

A

Tramadol

60
Q

Dopamine plays a primary role in the expression of reward in what part of the brain

A

Mesolimbic system

61
Q

Loss of appetite in methamphetamine use is due to increase in this neurotransmitter

A

Serotonin

62
Q

Congener of methamphetamine that act as sexual enhancers

A

MDMA

Ecstasy

63
Q

Treatment for MDMA overdose

A

Supportive

Hypertonic saline for hyponatremia

64
Q

Known effect of MDMA overdose

A

Profound hyponatremia

65
Q

Cocaine inhibits CNS transporters of these neurotransmitters

A

Dopamine
Norepinephrine
Serotonin

66
Q

Cocaine can cause a feeling that insects are crawling under the skin

A

Delusional parasitosis

67
Q

Most dangerous hallucinogenic agent

A

PCP

Phencyclidine

68
Q

Active ingredient tetrahydrocannabinol

Dream like state
Tachycardia
Reddened conjunctiva
Dry mouth

A

Marijuana

Pharma (15 decks)

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