Parkinsonism, Psych, Opioids, Abuse Flashcards by Jenica Dela Cruz

Primary drug for Parkinsonism

Levodopa Carbidopa

How well did you know this?

Not at all

Perfectly

Levodopa is contraindicated in patients with a history of

Psychosis

How well did you know this?

Not at all

Perfectly

Phenomenon in Parkinson wherr there is alternating periods of inproved mobility and akinesia over a few hours or days during the treatment

On- Off Phenomena

How well did you know this?

Not at all

Perfectly

Phenomenon in Parkinson where there is deterioration of drug effect in between doses

Due to progressive destruction of nigrostriatal neurons that occur with disease progression

Wearing off Phenomenon

How well did you know this?

Not at all

Perfectly

Partial agonist at dopamine D2 receptors in thr brain

Used in Parkinson, Levodopda intolerance and hyperprolactinemia

Can cause erythromelalgia

Bromocriptine

How well did you know this?

Not at all

Perfectly

Antiparkinsonism that is a partial agonist at D3 receptors

Compulsive gambling, hypersexuality overeating

Pramipexole

Ropinirole

How well did you know this?

Not at all

Perfectly

Antiparkinsonism drug that is a partial D3 agonist

Used for off periods of Parkinsonism

Severe nausea

Apomorphine

How well did you know this?

Not at all

Perfectly

Patients who are taking apomorphine should take this drug first to prevent severe nausea

Trimethobenzamide

How well did you know this?

Not at all

Perfectly

Antiparkinsonism drug that partially inhibits MAO B at a certain dose

Can cause serotonin syndrome when used with SSRI TCA Meperidine

Selegiline

Rasagiline

How well did you know this?

Not at all

Perfectly

COMT inhibitor that blocks L-dopa metabolism and prolongs response to levodopa

Orange urine
Hepatotoxic
Neuroleptic malignant syndrome
Rhabdomyolysis

Entacapone

Tolcapone

How well did you know this?

Not at all

Perfectly

Drug used to potentiate dopaminergic action

Can cause livedo reticularis

Amantadine

How well did you know this?

Not at all

Perfectly

Drugs that can cause livedo reticularis

A MAN reads fHM and GQ

Amantadine
Hydroxyurea
Minocycline
Gemcitabine
Quinidine

How well did you know this?

Not at all

Perfectly

Anticholinergic drug used for Parkinsons that blocks muscarinic receptors

Used to prevent EPS caused by antipsychotics
Little effect on bradykinesia

Benztropine 
Biperiden 
Trihexyphenidyl 
Orphenadine
Procyclidine

How well did you know this?

Not at all

Perfectly

This drug is effective in some schizophrenic patients resistant to treatment with other antipsychotics

Clozapine

How well did you know this?

Not at all

Perfectly

Dopaminergic tract for mentation and mood

Mesocortical-Mesolimbic

How well did you know this?

Not at all

Perfectly

Dopaminergic tract for extrapyramidal function

Nigrostriatal

How well did you know this?

Not at all

Perfectly

Dopaminergic tract for control of prolactin release

Tuberoinfundibular

How well did you know this?

Not at all

Perfectly

Irreversible disorder characterized by repetitive involuntary movements like tongue protrusion and lip smacking

Tardive dyskinesia

How well did you know this?

Not at all

Perfectly

Typical antipsychotic that blocks D2 receptors

EPS, failure of ejculation, corneal and lens deposits, NMS

Chlorpromazine

How well did you know this?

Not at all

Perfectly

Only antipsychotic with fatal overdose

Strongest autonomic effects

Thioridazine
Fluphenazine
Perphenazine

How well did you know this?

Not at all

Perfectly

Typical antipsychotic used for schizophrenia, manic phase of bipolar, Huntington and Tourette

Weakest autonomic effects
Less sedating

Haloperidol

How well did you know this?

Not at all

Perfectly

Atypical antipsychotic used for refractory schizophrenia

Only antipsychotic that reduces risk of suicide

Clozapine

How well did you know this?

Not at all

Perfectly

Antipsychotic than can cause agranulocytosis

Clozapine

Watch clozely for agranulocytosis

How well did you know this?

Not at all

Perfectly

Atypical antipsychotic that can cause weight gain

Olanzapine= Obesity

How well did you know this?

Not at all

Perfectly

Most sedating atypical antipsychotic

Quetiapine= Quiet- apine

Atypical antipsychotic less sedating than quetiapine Hyperprolactinemia

Risperidone Rise and Shine Rise to a pair

Only antipsychotic approved for schizophrenia in the youth

Risperidone

Atypical antipsychotic that can cause postural hypotension, QT prolongation

Ziprasidone

Least sedating atypical antipsychotic

Aripiprazole

Features of Neuroleptic Malignant Syndrome

``` FEVER Fever Encephalopathy Vitals unstable Elevated CPK Rigidity ```

Threshold for lithium toxicity

2 meq/L

Treatment for lithium overdose

Dialysis

Neurotransmitters involved in the expression of mood

NE | Serotonin

Antidepressant ( TCA) used for enuresis and MDD not responsive to other drugs

Imipramine IHI-pramine

3 Cs of TCA toxicity

Cardiotoxicity Convulsions Coma

TCAs mode of action is the blocksde of which transporters?

NE and 5HT ANS and histamine

First line for MDD

``` Fluoxetine Paroxitine Citalopram Escitalopram Sertraline Vilazodone ```

SSRIs can cause serotonin syndrome when used with what drug?

MAOIs

SSRI approved only for OCD

Fluvoxamine

SSRI that can cause diarrhea

Sertraline | Squirtraline

Drugs that can cause erectile dysfunction

A SORE PeniS can't Fuck Hard ``` SSRI Opiates Risperidone Ethanol, Estrogen Propranolol Spironolactone Finasteride Hydrochlorothiazide ```

Drugs that can cause priapism

Tigas PeniS Qo, AyaW Bumaba ``` Trazodone Papaverine Sildenafil Quetiapine Alprostadil Warfarin Bupropion ```

Tetracyclic antidepressant used for major depression

Mirtazapine

Tetracyclic antidepressant that inhibits neuronal reuptake of dopamine and NE Used for smoking cessation

Bupropion

MAOI (Phenelzine) can cause hypertensive crisis when taken with

Tyramine

Treatment for NMS

Diphenhydramine

Opioid with shortest half life

Remifentanil (3-4 mins)

Opioid with longest half life

Buprenorphine ( 4-8 hours)

Opioid analgesic against mu receptors Used for severe pain and adjunct for anesthesia

Morphine

Antidote for morphine

Naloxone

Opioid that is a strong agonist against mu receptors. Inhibits pain at spinal and supraspinal sites Used in severe pain, chronic pain, cancer pain

Fentanyl

Most potent opioid

Ohmefentanyl

Strong opioid agonist at mu and kappa receptors | Used for spasmodic pain

Meperidine

Strong opioid agonist at mu receptors Used for opioid dependence and withdrawal

Methadone

Partial opioid agonist at mu and kappa receptors used for chronic, neuropathic and cancer pain Can cause hypogonadism, hearing loss

Hydrocodone | Oxycodone

Partial opioid agonist used for cough suppression

Dextrometorphan | Codeine

Weak agonist at mu receptors used for mild to moderate pain and restless legs syndrome Withdrawn because of fatal cardiotoxicity Commonly used in suicide

Propoxyphene

Mixed opioid agonist-antagonist Strong agonist at kappa and weak antagonist at mu receptors Used for alcohol dependence

Nalbuphine

Dual acting opioid analgesic Weak agonist at mu receptors for moderate pain Lowers seizure threshold, nausea and vomiting

Tramadol

Dopamine plays a primary role in the expression of reward in what part of the brain

Mesolimbic system

Loss of appetite in methamphetamine use is due to increase in this neurotransmitter

Serotonin

Congener of methamphetamine that act as sexual enhancers

MDMA | Ecstasy

Treatment for MDMA overdose

Supportive | Hypertonic saline for hyponatremia

Known effect of MDMA overdose

Profound hyponatremia

Cocaine inhibits CNS transporters of these neurotransmitters

Dopamine Norepinephrine Serotonin

Cocaine can cause a feeling that insects are crawling under the skin

Delusional parasitosis

Most dangerous hallucinogenic agent

PCP | Phencyclidine

Active ingredient tetrahydrocannabinol Dream like state Tachycardia Reddened conjunctiva Dry mouth

Marijuana