NSAIDS, DMARDS, Gout Flashcards
Non selective NSAID that prevents uric acid excretion
Aspirin
Treatment for aspirin overdose
Activated charcoal/ gastric lavage
Alkalinize urine with bicarbonate
Long term use of this drug reduces the risk of colon cancer
NSAIDs
Drug that prevents NSAID induced gastritis
Misoprostol
Intravenous NSAID that is mainly used for analgesia
Use is generally restricted to 72 hrs only
Ketorolac
Dexketoprofen
NSAID used for closure of PDA
Inhibits COX 1 more than COX 2
Indomethacin
Limit dose of paracetamol
4 grams
Antidote of paracetamol
N- acetylcysteine
Most common cause of liver failure
Paracetamol
Lethal dose of paracetamol
15g
Most common form of chronic inflammatory arthritis
Rheumatoid arthritis
DMARD that inhibits AICAR transformylase and thymidylate synthetase
DMARD if choice for rheumatoid arthritis
Methotrexate
Rescue agent of Methotrexate
Leucovirin
DMARD that inhibits TNF a that is used for Crohns and rheumatoid arthritis
Infliximab
DMARD that is a purine analog and forms 6-thioguanine that suppress inosinic acid synthesis
Azathioprine
This drug cannot be given with azathioprine because it leads to severe leukopenia
Allopurinol
DMARD that can cause hemorrhagic cystitis
Cyclophosphamide
Rescue agent for cyclophosphamide
MESNA
DMARD that can cause hirsutism, nephrotoxicity and gingival hyperplasia
Cyclosporine
DMARD that is used for SLE nephritis, Wegeners and rheumatoid with reversible myelosuppresion
Mycophenolate Mofetil
DMARD that inhibits release of cytokines
Used for RA, IBD
Can cause methemoglobinemia, hemolytic anemia, reversible infertility in men
Sulfasalazine
Monoclonal antibody that is used for moderate to severe rheumatoid arthritis with Methotrexate in patients with inadequate response to TNF a
Rituximab
Monoclonal antibody that binds to IL-6 and used for moderate to severe RA in patients with inadequate response to TNF a
Do not use in patients with Diverticulitis
Tocilizumab
Anti gout drug that inhibits microtubule assembly and decreases macrophage phagocytosis
Used also in family Mediterranean fever
Can cause diarrhea, AKI and agranulocytosis
Colchicine
This NSAID is not used in Gout due to renal retention of uric acid
Aspirin
This drug is commonly used in the initial treatment of gout as a replacement for colchicine
Indomethacin
Uricosuric agent that may precipitate acute gout during early phase of drug action
Can cause nephrotic syndrome and aplastic anemia
Probenecid
Xanthine oxidase inhibitor that is the first line for chronic gout
Allopurinol
Allopurinol can cause this idiosyncratic reaction
Cataract
Nonpurine reversible xanthine oxidase inhibitor for chronic gout
Febuxostat
