NSAIDS, DMARDS, Gout

Question 1

Non selective NSAID that prevents uric acid excretion

Answer 1

Aspirin

Question 2

Treatment for aspirin overdose

Answer 2

Activated charcoal/ gastric lavage

Alkalinize urine with bicarbonate

Question 3

Long term use of this drug reduces the risk of colon cancer

Answer 3

NSAIDs

Question 4

Drug that prevents NSAID induced gastritis

Answer 4

Misoprostol

Question 5

Intravenous NSAID that is mainly used for analgesia

Use is generally restricted to 72 hrs only

Answer 5

Ketorolac

Dexketoprofen

Question 6

NSAID used for closure of PDA

Inhibits COX 1 more than COX 2

Answer 6

Indomethacin

Question 7

Limit dose of paracetamol

Answer 7

4 grams

Question 8

Antidote of paracetamol

Answer 8

N- acetylcysteine

Question 9

Most common cause of liver failure

Answer 9

Paracetamol

Question 10

Lethal dose of paracetamol

Answer 10

15g

Question 11

Most common form of chronic inflammatory arthritis

Answer 11

Rheumatoid arthritis

Question 12

DMARD that inhibits AICAR transformylase and thymidylate synthetase

DMARD if choice for rheumatoid arthritis

Answer 12

Methotrexate

Question 13

Rescue agent of Methotrexate

Answer 13

Leucovirin

Question 14

DMARD that inhibits TNF a that is used for Crohns and rheumatoid arthritis

Answer 14

Infliximab

Question 15

DMARD that is a purine analog and forms 6-thioguanine that suppress inosinic acid synthesis

Answer 15

Azathioprine

Question 16

This drug cannot be given with azathioprine because it leads to severe leukopenia

Answer 16

Allopurinol

Question 17

DMARD that can cause hemorrhagic cystitis

Answer 17

Cyclophosphamide

Question 18

Rescue agent for cyclophosphamide

Answer 18

MESNA

Question 19

DMARD that can cause hirsutism, nephrotoxicity and gingival hyperplasia

Answer 19

Cyclosporine

Question 20

DMARD that is used for SLE nephritis, Wegeners and rheumatoid with reversible myelosuppresion

Answer 20

Mycophenolate Mofetil

Question 21

DMARD that inhibits release of cytokines

Used for RA, IBD

Can cause methemoglobinemia, hemolytic anemia, reversible infertility in men

Answer 21

Sulfasalazine

Question 22

Monoclonal antibody that is used for moderate to severe rheumatoid arthritis with Methotrexate in patients with inadequate response to TNF a

Answer 22

Rituximab

Question 23

Monoclonal antibody that binds to IL-6 and used for moderate to severe RA in patients with inadequate response to TNF a

Do not use in patients with Diverticulitis

Answer 23

Tocilizumab

Question 24

Anti gout drug that inhibits microtubule assembly and decreases macrophage phagocytosis

Used also in family Mediterranean fever
Can cause diarrhea, AKI and agranulocytosis

Answer 24

Colchicine

Question 25

This NSAID is not used in Gout due to renal retention of uric acid

Answer 25

Aspirin

Question 26

This drug is commonly used in the initial treatment of gout as a replacement for colchicine

Answer 26

Indomethacin

Question 27

Uricosuric agent that may precipitate acute gout during early phase of drug action

Can cause nephrotic syndrome and aplastic anemia

Answer 27

Probenecid

Question 28

Xanthine oxidase inhibitor that is the first line for chronic gout

Answer 28

Allopurinol

Question 29

Allopurinol can cause this idiosyncratic reaction

Answer 29

Cataract

Question 30

Nonpurine reversible xanthine oxidase inhibitor for chronic gout

Answer 30

Febuxostat