NSAIDS, DMARDS, Gout Flashcards

1
Q

Non selective NSAID that prevents uric acid excretion

A

Aspirin

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2
Q

Treatment for aspirin overdose

A

Activated charcoal/ gastric lavage

Alkalinize urine with bicarbonate

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3
Q

Long term use of this drug reduces the risk of colon cancer

A

NSAIDs

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4
Q

Drug that prevents NSAID induced gastritis

A

Misoprostol

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5
Q

Intravenous NSAID that is mainly used for analgesia

Use is generally restricted to 72 hrs only

A

Ketorolac

Dexketoprofen

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6
Q

NSAID used for closure of PDA

Inhibits COX 1 more than COX 2

A

Indomethacin

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7
Q

Limit dose of paracetamol

A

4 grams

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8
Q

Antidote of paracetamol

A

N- acetylcysteine

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9
Q

Most common cause of liver failure

A

Paracetamol

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10
Q

Lethal dose of paracetamol

A

15g

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11
Q

Most common form of chronic inflammatory arthritis

A

Rheumatoid arthritis

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12
Q

DMARD that inhibits AICAR transformylase and thymidylate synthetase

DMARD if choice for rheumatoid arthritis

A

Methotrexate

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13
Q

Rescue agent of Methotrexate

A

Leucovirin

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14
Q

DMARD that inhibits TNF a that is used for Crohns and rheumatoid arthritis

A

Infliximab

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15
Q

DMARD that is a purine analog and forms 6-thioguanine that suppress inosinic acid synthesis

A

Azathioprine

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16
Q

This drug cannot be given with azathioprine because it leads to severe leukopenia

A

Allopurinol

17
Q

DMARD that can cause hemorrhagic cystitis

A

Cyclophosphamide

18
Q

Rescue agent for cyclophosphamide

19
Q

DMARD that can cause hirsutism, nephrotoxicity and gingival hyperplasia

A

Cyclosporine

20
Q

DMARD that is used for SLE nephritis, Wegeners and rheumatoid with reversible myelosuppresion

A

Mycophenolate Mofetil

21
Q

DMARD that inhibits release of cytokines

Used for RA, IBD

Can cause methemoglobinemia, hemolytic anemia, reversible infertility in men

A

Sulfasalazine

22
Q

Monoclonal antibody that is used for moderate to severe rheumatoid arthritis with Methotrexate in patients with inadequate response to TNF a

23
Q

Monoclonal antibody that binds to IL-6 and used for moderate to severe RA in patients with inadequate response to TNF a

Do not use in patients with Diverticulitis

A

Tocilizumab

24
Q

Anti gout drug that inhibits microtubule assembly and decreases macrophage phagocytosis

Used also in family Mediterranean fever
Can cause diarrhea, AKI and agranulocytosis

A

Colchicine

25
This NSAID is not used in Gout due to renal retention of uric acid
Aspirin
26
This drug is commonly used in the initial treatment of gout as a replacement for colchicine
Indomethacin
27
Uricosuric agent that may precipitate acute gout during early phase of drug action Can cause nephrotic syndrome and aplastic anemia
Probenecid
28
Xanthine oxidase inhibitor that is the first line for chronic gout
Allopurinol
29
Allopurinol can cause this idiosyncratic reaction
Cataract
30
Nonpurine reversible xanthine oxidase inhibitor for chronic gout
Febuxostat