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Pharma > GIT, Toxicology > Flashcards

GIT, Toxicology Flashcards

1
Q

Neutralizes stomach acid by reacting with protons in the lumen of the gut

A

Magnesium-Aluminum hydroxide

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2
Q

Competitive H2 receptor blocker

A

Cimetidine
Ranitidine
Famotidine
Nizatidine

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3
Q

Highly effective in suppressing nocturnal acid

A

H2 receptor blockers

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4
Q

H2 blocker that can cause gynecomastia

A

Cimetidine

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5
Q

Omeprazole causes irreversible blockade of ______ in active gastric parietal cells

A

H K ATPase

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6
Q

Drug of choice for peptic ulcer disease

A

Omeprazole

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7
Q

Mucosal protective agent that binds to injured tussue and forms a protective covering over ulcer beds

A

Sucralfate

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8
Q

Mucosal protective agent that activates EP receptors that causes HCO3 and mucus secretion in stomach

Also causes uterine contraction

A

Misoprostol

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9
Q

Mucosal protective agent that forms a protective coating on ulcerated tissue, stimulates mucosal protective mechanisms

Black stools, darkening of tongue

A

Bismuth salicylate

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10
Q

Prokinetic agent that blocks D2 receptors that increases intestinal motility and gastric emptying

DOC for DM gastroparesis
Antiemetic

A

Metoclopramide

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11
Q

Bulk forming laxative

Forms indigestible hydrophilic colloids that absorb water which promotes peristalsis

A

Psyllium
Methylcellulose
Polycarbophil

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12
Q

Stool softening laxative that permits water and lipids to penetrate

Can cause malabsorption of ADEK

A

Docusate
Mineral oil
Glycerin suppository

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13
Q

Osmotic laxative that has solube but nonabsorbable compounds, increasing fecal fluid

Can cause electrolyte abnormality

A 
Lactulose
Polyethylene glycol
Mg Oxide
Sorbitol
Mg citrate 
Na phosphate
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14
Q

Stimulant/cathartic laxative that directly stimulates enteric nervous system

Can cause melanosis coli

A 
Bisacodyl
Senna
Aloe
Castor oil
Cascara
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15
Q

Anti diarrheal that activates opioid receptors in enteric nervous system

Can cause paralytic ileus

A

Diphenoxylate
Loperamide
Colloidal bismuth
Kaolin + pectin

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16
Q

Paralytic ileus can be reversed by giving

A

Betanechol

17
Q

Antiemetic that blocks the chemoreceptor trigger zone and 5 HT3 receptors

A 
Ondansetron
Granisetran
Dolasetron
Palonosetron
Alosteron
18
Q

Immumodulator used for IBD

Not useful for acute flare ups

A 
(5-ASA)
Mesalamine
Balsalazide
Olsalazine
Sulfasadine
19
Q

Organophosphate poisoning

DUMBBELSS

A 
Diarrhea 
Urination
Miosis
Bronchospasm
Bradycardia 
Excitation (CNS, skeletal ms)
Lacrimation
Sweating
Salivation
20
Q

Most common cause of death in organophosphate poisoning

A

Respiratory failure

21
Q

Treatment for organophosphate poisoning

A

Atropine

Pralidoxime

22
Q

Long term exposure to this herbicide can cause NH lymphoma

A

Chlorophenoxy acid

23
Q

Most widely used herbicide in the world

A

Glyphosate

24
Q

Lead poisoning treatment

A

Oral succimer- OPD

EDTA with or without dimercaprol

25
Q

Treatment for arsenic poisoning

A

Dimercaprol

26
Q

Treatment for ACUTE INORGANIC mercury poisoning

A

Dimeraprol or oral succimer

27
Q

Treatment for CHRONIC INORGANIC mercury poisoning

A

Succimer and Unithiol

Do not give dimercaprol- may redistribute mercury to the CNS

28
Q

Treatment for Iron poisoning

A

Deferoxamine

29
Q

Treatment for copper poisoning and Wilson’s disease

A

Penicillamine

30
Q

Treatment for severe chronic lead poisoning

A

EDTA

31
Q

Antidote for opioids

A

Naloxone

32
Q

Treatment for benzodiazepine overdose

A

Flumazenil

Pharma (15 decks)

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