Drugs for Hyperlipidemia

Question 1

Simvastatin Mode of Action

Answer 1

Increased number of LDL receptors

Question 2

Simvastatin is a reversible competitive inhibitor of

Answer 2

HMG COA reductase

Question 3

Simvastatin lowers?

Answer 3

LDL

Modest triglycerides

Question 4

Simvastatin: Increased risk when used with fibrates

Answer 4

Rhabdomyolysis

Myopathy

Question 5

Simvastatin increased risk of myopathy and rhabdomyolysis when used with?

Answer 5

Fibrates

Question 6

Use of statins in CAD

Answer 6

Stabilization of athrosclerotic plaques

Question 7

Stabilization of plaque in CAD for statins occurs due to

Answer 7

Inhibition of further platelet aggregation

Question 8

Resins MOA

Answer 8

Binds bile acids, prevents reabsorption

Question 9

Uses of Cholestyramine

Answer 9

High LDL
Cholestatic pruritus
Digitalis toxicity

Question 10

Side effects of Cholestyramine

Answer 10

Constipation
Bloating
Gritty taste
Steatorrhea

Question 11

Cholestyramine inhibits absorption of what vitamin?

Answer 11

Vitamin K

Question 12

Cholestyramine increases this type of cholesterol?

Answer 12

TG

VLDL

Question 13

Cholestyramine should be avoided in patients with

Answer 13

Diverticulitis

Increased TG

Question 14

Other names for Cholestyramine

Answer 14

Colestipol

Colesevelam

Question 15

Ezetemibe MOA

Answer 15

Inhibits NPC1L1 receptor that prevents absorption of dietary cholesterol

Question 16

Ezetemibe inhibits what receptor?

Answer 16

NPC1L1

Question 17

Ezetemibe lowers what type of cholesterol

Answer 17

LDL

Question 18

Ezetemibe side effects

Answer 18

Hepatotoxicity

Question 19

Ezetemibe is synergistic with?

Answer 19

Statins

Question 20

What hyperlipidemic agent is a cholesterol analog?

Answer 20

Sitosterol

Question 21

Suicide inhibitor of LDL

Answer 21

Sitosterol

Question 22

Niacin decreases catabolism of

Answer 22

ApoA1

Question 23

Niacin increases which type of lipid?

Answer 23

HDL

Question 24

The most effective agent for increasing HDL levels

Answer 24

Niacin

Question 25

Niacin inhibits lipolysis due to which enzyme?

Answer 25

Hormone sensitive lipase

Question 26

Niacin's action in the liver

Answer 26

Reduce VLDL synthesis

Question 27

Niacin's action in the adipose tissue

Answer 27

Decreased fatty acid and TG levels

Question 28

Niacin increase HDL by

Answer 28

Reducing catabolic rate

Question 29

Niacin causes? (Side effects)

Answer 29

Flushing Hyperuricemia Impaired glucose tolerance

Question 30

Niacin: | ______pretreatment reduces flushing

Answer 30

Aspirin

Question 31

Niacin should be avoided in patients with:

Answer 31

Peptic ulcer disease

Question 32

What are the drugs that cause cutaneous flushing?

Answer 32

``` V-A-N-C Vanco Adenosine Niacin CCB ```

Question 33

Increases HDL levels

Answer 33

Gemfibrozil (Fibrates) | Niacin

Question 34

Gemfibrozil activates this protein

Answer 34

PPAR alpha | Proliferator activated receptor alpha

Question 35

Gemfibrozil increase expression of what enzyme?

Answer 35

Lipoprotein lipase

Question 36

What apoproteins are affected in fibrates?

Answer 36

Apo A1 Apo A2 Decreased apo C3

Question 37

Fibrates: | Decreased expression of what lipoprotein?

Answer 37

Apo C3

Question 38

Fibrates: | Increased expression of which lipoprotein?

Answer 38

Apo A1 | Apo A2

Question 39

Gemfibrozil stimulates what pathway in the liver?

Answer 39

Fatty acid oxidation

Question 40

Gemfibrozil has no effect on which lipid concentration?

Answer 40

LDL

Question 41

Fibrates increases and decreases which type of lipids?

Answer 41

Increase HDL | Decreased VLDL TG

Question 42

Gemfibrozil is the DOC for?

Answer 42

Hypertriglyceridemia

Question 43

Gemfibrozil has increased risk for developing?

Answer 43

Cholesterol gallstones Myopathy Rhabdomyolysis when used with statins

Question 44

Fibrate+ Resin- increased risk for?

Answer 44

Cholelithiasis

Question 45

Statin + Resin- increased risk for?

Answer 45

Impaired statin absorption

Question 46

Statin + fibrate- increased risk for?

Answer 46

Myopathy | Rhabdomyolysis

Question 47

Lipoprotenemias: Deficiency in LPL or apo c2 Increased Chylomicrons

Answer 47

Primary Hyperchylomicronemia | Type 1

Question 48

Lipoproteinemia Deficient LDL receptors Increased LDL

Answer 48

Familial hypercholesterolemia | Type 2a