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Drugs for Hyperlipidemia Flashcards

1
Q

Simvastatin Mode of Action

A

Increased number of LDL receptors

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2
Q

Simvastatin is a reversible competitive inhibitor of

A

HMG COA reductase

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3
Q

Simvastatin lowers?

A

LDL

Modest triglycerides

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4
Q

Simvastatin: Increased risk when used with fibrates

A

Rhabdomyolysis

Myopathy

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5
Q

Simvastatin increased risk of myopathy and rhabdomyolysis when used with?

A

Fibrates

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6
Q

Use of statins in CAD

A

Stabilization of athrosclerotic plaques

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7
Q

Stabilization of plaque in CAD for statins occurs due to

A

Inhibition of further platelet aggregation

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8
Q

Resins MOA

A

Binds bile acids, prevents reabsorption

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9
Q

Uses of Cholestyramine

A

High LDL
Cholestatic pruritus
Digitalis toxicity

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10
Q

Side effects of Cholestyramine

A

Constipation
Bloating
Gritty taste
Steatorrhea

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11
Q

Cholestyramine inhibits absorption of what vitamin?

A

Vitamin K

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12
Q

Cholestyramine increases this type of cholesterol?

A

TG

VLDL

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13
Q

Cholestyramine should be avoided in patients with

A

Diverticulitis

Increased TG

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14
Q

Other names for Cholestyramine

A

Colestipol

Colesevelam

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15
Q

Ezetemibe MOA

A

Inhibits NPC1L1 receptor that prevents absorption of dietary cholesterol

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16
Q

Ezetemibe inhibits what receptor?

A

NPC1L1

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17
Q

Ezetemibe lowers what type of cholesterol

A

LDL

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18
Q

Ezetemibe side effects

A

Hepatotoxicity

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19
Q

Ezetemibe is synergistic with?

A

Statins

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20
Q

What hyperlipidemic agent is a cholesterol analog?

A

Sitosterol

21
Q

Suicide inhibitor of LDL

A

Sitosterol

22
Q

Niacin decreases catabolism of

23
Q

Niacin increases which type of lipid?

24
Q

The most effective agent for increasing HDL levels

25
Q

Niacin inhibits lipolysis due to which enzyme?

A

Hormone sensitive lipase

26
Q

Niacin’s action in the liver

A

Reduce VLDL synthesis

27
Q

Niacin’s action in the adipose tissue

A

Decreased fatty acid and TG levels

28
Q

Niacin increase HDL by

A

Reducing catabolic rate

29
Q

Niacin causes? (Side effects)

A

Flushing
Hyperuricemia
Impaired glucose tolerance

30
Q

Niacin:

______pretreatment reduces flushing

31
Q

Niacin should be avoided in patients with:

A

Peptic ulcer disease

32
Q

What are the drugs that cause cutaneous flushing?

A 
V-A-N-C
Vanco
Adenosine
Niacin
CCB
33
Q

Increases HDL levels

A

Gemfibrozil (Fibrates)

Niacin

34
Q

Gemfibrozil activates this protein

A

PPAR alpha

Proliferator activated receptor alpha

35
Q

Gemfibrozil increase expression of what enzyme?

A

Lipoprotein lipase

36
Q

What apoproteins are affected in fibrates?

A

Apo A1
Apo A2
Decreased apo C3

37
Q

Fibrates:

Decreased expression of what lipoprotein?

38
Q

Fibrates:

Increased expression of which lipoprotein?

A

Apo A1

Apo A2

39
Q

Gemfibrozil stimulates what pathway in the liver?

A

Fatty acid oxidation

40
Q

Gemfibrozil has no effect on which lipid concentration?

41
Q

Fibrates increases and decreases which type of lipids?

A

Increase HDL

Decreased VLDL TG

42
Q

Gemfibrozil is the DOC for?

A

Hypertriglyceridemia

43
Q

Gemfibrozil has increased risk for developing?

A

Cholesterol gallstones
Myopathy
Rhabdomyolysis when used with statins

44
Q

Fibrate+ Resin- increased risk for?

A

Cholelithiasis

45
Q

Statin + Resin- increased risk for?

A

Impaired statin absorption

46
Q

Statin + fibrate- increased risk for?

A

Myopathy

Rhabdomyolysis

47
Q

Lipoprotenemias:
Deficiency in LPL or apo c2
Increased Chylomicrons

A

Primary Hyperchylomicronemia

Type 1

48
Q

Lipoproteinemia
Deficient LDL receptors
Increased LDL

A

Familial hypercholesterolemia

Type 2a

Pharma (15 decks)

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