Histamine Serotonin And Ergot Alkaloids Flashcards
What is the triple response of Lewis
Wheal
Flush
Flare
H1 receptor uses what mechanism
Increased IP3 DAG
H2 receptors uses what mehanism?
Increased cAMP
Carbinoxamine Dimehydrinate Hydroxyzine Promethazine Cyproheptadine
Less common names of 1st generation H1 receptor antagonist
Which H1 receptor blocker also inhibits serotonin?
Cyproheptadine
Which H1 receptor antagonist is used as an appetite stimulant?
Cyclizine
Which H1 receptor antagonist is used as an antiemetic?
Promethazine
Which is used for serotonin syndrome?
Cyproheptadine
Fexofenadine
Terfenadine
Astemizole
Less common names of cetirizine
Fatal arryhthmias can occur with use of terfenadine, astemizole and?
Azoles
Erythromycin
Used in prevention of nocturnal acid attacks
Cimetidine (H2)
Famotidine is a CYP450 and can cause?
Inhibitor
Gynecomastia
Serotonin is produced from what amino acid?
Tryotophan
Sumatriptan affects which receptor?
5HT 1D receptor
Drug of choice for acute migraine?
Sumatriptan
Triptans
Triptans causes what on the blood vessel
Vasoconstriction
Ondansetron is an antagonist of
5HT 3
Palonosteron is used for
Chemotherapy and post op vomiting
Alosetron only causes
Constipation
Dolasetron only causes?
QT prolongation
Ergotamine is a ___ 5HT 2 antagonist
Vasoselective
Ergonovine is a _____ 5HT2 antagonist
Uteroselective
Methysergide causes (SE)
Retroperitoneal fibrosis
Antidote for dihydroergotamine
Nitroprusside
