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Pharma > Histamine Serotonin And Ergot Alkaloids > Flashcards

Histamine Serotonin And Ergot Alkaloids Flashcards

1
Q

What is the triple response of Lewis

A

Wheal
Flush
Flare

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2
Q

H1 receptor uses what mechanism

A

Increased IP3 DAG

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3
Q

H2 receptors uses what mehanism?

A

Increased cAMP

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4
Q 
Carbinoxamine
Dimehydrinate
Hydroxyzine
Promethazine
Cyproheptadine
A

Less common names of 1st generation H1 receptor antagonist

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5
Q

Which H1 receptor blocker also inhibits serotonin?

A

Cyproheptadine

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6
Q

Which H1 receptor antagonist is used as an appetite stimulant?

A

Cyclizine

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7
Q

Which H1 receptor antagonist is used as an antiemetic?

A

Promethazine

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8
Q

Which is used for serotonin syndrome?

A

Cyproheptadine

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9
Q

Fexofenadine
Terfenadine
Astemizole

A

Less common names of cetirizine

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10
Q

Fatal arryhthmias can occur with use of terfenadine, astemizole and?

A

Azoles

Erythromycin

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11
Q

Used in prevention of nocturnal acid attacks

A

Cimetidine (H2)

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12
Q

Famotidine is a CYP450 and can cause?

A

Inhibitor

Gynecomastia

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13
Q

Serotonin is produced from what amino acid?

A

Tryotophan

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14
Q

Sumatriptan affects which receptor?

A

5HT 1D receptor

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15
Q

Drug of choice for acute migraine?

A

Sumatriptan

Triptans

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16
Q

Triptans causes what on the blood vessel

A

Vasoconstriction

17
Q

Ondansetron is an antagonist of

A

5HT 3

18
Q

Palonosteron is used for

A

Chemotherapy and post op vomiting

19
Q

Alosetron only causes

A

Constipation

20
Q

Dolasetron only causes?

A

QT prolongation

21
Q

Ergotamine is a ___ 5HT 2 antagonist

A

Vasoselective

22
Q

Ergonovine is a _____ 5HT2 antagonist

A

Uteroselective

23
Q

Methysergide causes (SE)

A

Retroperitoneal fibrosis

24
Q

Antidote for dihydroergotamine

A

Nitroprusside

25
Q

Ergonovine is used for

A

Postpartum bleeding

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