Autonomics Flashcards
Sympathetic effect on blood vessels of the skin
Constriction
Sympathetic effect on skeletal blood vessels
Vasodilation
Sympathetic effect on GIT and bladder wall
Relaxation
Sympathetic effect on GIT and bladder sphincter
Contraction
B1 receptors are found in
Heart and kidneys
D1 receptors are found in
Renal splanchnic
D2 and D3 receptors are found in
CNS
Thoracolumbar
CNS
Craniosacral
Peripheral
Long preganglionic nerve
Parasympathetic
Effect of sympathetic response on uterus
Both contraction and relaxation
Primary transmitter at the somatic skeletal muscle NMJ
Acetylcholine
Acetylcholine is synthesized from acetyl CoA and choline by what enzyme
Choline acetyltransferase
Choline transport is inhibited by
Hemicholinuim
Ach is transported into vesicle and inhibited by
Vesamicol
This alters synaptobrevins to prevent release of Ach
Botulinum toxin
Inhibits action of acetylcholinesterase
Neostigmine
Carbamates
Organophosphates
Cholinomimetic that activates M receptors and is used for bowel and bladder atony
Betanechol
M3 selective muscarinic drug that is found in ciliary muscle and salivary glands
Used in glaucoma
Pilocarpine
Triad of Sjogren syndrome
Xerostomia
Xerophthalmia
Rheumatoid arthritis
Activates nicotinic Ach receptors and used for smoking cessation
Varenicline
MOA of indirect acting cholinomimetics
Bind to cholinesterase and undergo hydrolysis
Indirect acting cholinomimetic used for the DIAGNOSIS of myasthenia gravis
Edrophonium
Neostigmine
Used for reversal of nondepolarizing neuromuscular blockade
Neostigmine
Indirect cholinomimetic used for glaucoma
Physostigmine
Echothiophate
Demecarium
Neostigmine muscarinic effects are blocked by
Atropine
Acute worsening of symptoms due to infection, stress or UNDERmedication
Myasthenic crisis
Excessive activation of cholinoceptors due to overstimulation
Cholinergic crisis
Signs of cholinergic crisis
Skeletal muscle weakness and parasympathetic signs
Galantamine
Donezepil
Tacrine
Rivastigmine
Indirect acting cholinomimetic used in alzheimers disease
Rivastigmine
Organophosphate poisoning
DUMBBELSS
Diarrhea Urination Miosis Bronchospasm Bradycardia Excitation (skeletalcms and CNS) Emesis Lacrimation Sweating Salivation
Antidote for organophosphate poisoning
Atropine
Cholinergic antagonist that competitively blocks all muscarinic receptors
Atropine
Cholinergic antagonist notorius for causing hyperthermia
Atropine
Cholinesterase regenerator
Pralidoxime
Binds phosphorus of organophosphates and breaks bonds with cholinesterase
Pralidoxime
Pralidoxime must be administered before ____ of organophosphate poisoning
6-8 hours
Cholinergic muscarinic antagonist that is used for Parkinson’s disease
Benztropine
Biperiden
Trihexyphenidyl
Benztropine reduces more ___ than bradykinesia or rigidity
Tremors
Muscarinic antagonists for Parkinsonism
TRI to park your Benz, BIP here
Trihexyphenidyl
Benztropine
Biperiden
Cholinergic antagonist that blocks muscarinic receptors in bronchial smooth muscle
Ipratropium
Tiotropium
More effective cholinergic antagonist more effective in COPD and heart disease
Ipratropium
Tiotropium
Cholinergic antagonist that antagonizes histamine and serotonin
Scopolamine
Cholinergic antagonist that blocks M3 receptors
Used in IBS
Hyoscyamine
Glycopyrrolate
Dicyclomine
Cholinergic antagonist that has increased IOP as side effect
Dicyclomine and Oxybutynin
Cholinergic antagonist that reduces detrusor muscle tone and used for urge incontinence
Oxybutynin
Atropine Toxicity
Hot as a hare Dry as a bone Red as a beet Blind as a bat Mad as a hatter
Contraindications to muscarinic blockers
Infants
Angle closure glaucoma
BPH
First succesful agents for the treatment of hypertension
Ganglion blockers
Competitive pharma antagonists at nicotinic acetylcholine receptors
Hexamethonium
Trimethaphan
Mecamylamine
(Ganglion Blockers)
Primary neurotransmitter at the sympathetic postganglionic neuron-effector cell synapses in most tissues
Norepinephrine
Nonselective MAOI for depression
TIP
Tranylcypromine
Isocarboxazid
Phenelzine
Inactivating enzymes for catecholamines
MAO
COMT
MAO A or MAO B:
Norepinephrine and Epinephrine?
MAO A
MAO A or MAO B:
Dopamine?
MAO B
Tyrosine is hydroxylated by _____________to DOPA
Tyrosine hydroxylase
Tyrosine hydroxylase is inhibited by this drug
Metyrosine
Vesicular transport of norepinephrine and dopamine is inhibited by
Reserpine
This drug prevents entry of calcium that promotes release of norepinephrine
Guanethidine
Release of norepinephrine is promoted by
Amphetamine
Tyramine
Diffusion and reuptake of norepinephrine is blocked by
Cocaine and TCA
Diffusion and reuptake of NE is promoted by
MAOI and COMT inhibitors
Effect of alpha 2 receptors on platelets
Aggregation
Effect of B1 in kidneys
Release renin
Nonselective beta agonist used for asthma
Isoproterenol
Alpha 1 selective agonist used as nasal decongestant, mydriatic
Phenylephrine Tetrahydrozoline Xylometazoline Midodrine Naphazoline
Side effect of phenylephrine
Rebound nasal congestion
Rhinitis medicamentosa
Generic side effect of alpha 2 agonists
Sedation
Alpha 2 selective agonist that is used for hypertension
Clonidine
Used to treat rebound HTN in clonidine
Phentolamine
Other names: Guanfacibe Guanabenz Dexmedetomidine Tizanidine
Methydopa
Known side effect of methyldopa
Hemolytic anemia (positive coombs test)
Alpha 2 selective used to treat galucoma by decreasing secretion of aqueous humor
Apraclonidine
Brimonidine
Beta 2 selective agonist used as tocolysis for preterm labor
Terbutaline
Ritodrine
Cardioselective B1 blockers
NBEAM
Nebivolol Betaxolol Esmolol Atenolol, Alprenolol, Acebutalol Metoprolol
IRREVERSIBLY blocks alpha receptors
Used for pheochromocytoma
Phenoxybenzamine
drug used for pheochromocytoma that REVERSIBLY blocks alpha receptors
Phentolamine
Tolazoline
Most selective alpha 1 selective antagonist used for prostatic smooth muscle
Tamsulosin
Pharmacologic advantage of alpha 1 selectivity?
Less severe and less commin reflec tachycardia
Used for pheochromocytoma that has combined alpha and beta blockade
Carvedilol and labetalol
Beta blockers with intrinsic sympathomimetic activity
ISA PA
Pindolol
Acebutolol
-------- Carteolol Bopindolol Oxprenolol Celiprolol Penbutolol
Beta blockers with NO local anesthetic activity
Timolol
Betaxolol
Longest half life beta blocker
Nadolol
Shortest half life beta blocker
Esmolol