Cancer Flashcards
Cancer drugs acting on the M phase
Vincristine
Vinblastine
Paclitaxel
Cancer drugs acting on the G2 phase
Bleomycin
Cancer drugs acting on the S phase
CHEM 66
Cytarabine Hydroxyurea Etoposide Methotrexate 6- mercaptopurine 6- thioguanine
Rescue drug for methotrexate
Leucovorin
Rescue drug of cyclophosphamide
MESNA
Rescue drug for doxorubicin
Dexrazoxane
Rescue drug for cisplatin
Amifostine
Alkylating agent, cell cycle non specific for non Hodgkin lymphoma
Can cause hemorrhagic cystitis
Cyclophosphamide
Cyclophosphamide can cause hemorrhagic cystitis because it forms ____ which can cause direct toxicity to the bladder
Acrolein
Platinum based alkylating agent, CCNS, used for testicular, ovarian, advanced colon cancer
Nephrotoxic and can cause acoustic nerve damage
Cisplatin
Nephrotoxicity of cisplatin can be minimized by forced hydration and administration of this drug
Mannitol
Alkylating agent, CCNS for hodgkin and non hodgkin lymphoma
Procarbazine
Dacarbazine
Alkylating agent for CML
Bone marrow sparing
Busulfan
Drugs causing pulmonary fibrosis
BBBAN Me
Bleomycin Busulfan Bromocriptine Amiodarone Nitrofurantoin Methotrexate
Nitrosourea alkylating agent that is used for brain tumors, highly lipophilic that can cause BBB
Carmustine
Lomustine
Bendamustine
Methotrexate inhibits what enzyme?
Dihydrofolate reductase
Antimetabolite, S Phase specific, DMARD
Used for choriocarcinoma, primary CNS lymphoma, RA, psoriasis, ectopic pregnancy
Methotrexate
Purine antimetabolite that inhibits de novo purine nucleotide synthesis
For acute leukemias
6-Mercaptopurine
6-thioguanine
Pyrimidine antimetabolite that inhibits thymidylate synthase, causes thymine less death of cells
Colorectal cancer and skin cancer
5-FU
Pyrimidine antimetabolite that inhibits ribonucleotide reductase
Used for acute leukemias and CML in blast crisis
Cytarabine
Most specific drug for the S phase
Cytarabine
Pyrimidine antimetabolite that inhibits ribonucleotide reductase
For pancreatic cancer
Gemtacibine
Capetacibine- prodrug of 5 FU
Vinca alkaloid that prevents microtubule assembly can cause cell arrest at metaphase
Acute leukemia, wilms tumor, neuroblastoma
Acts on M phase
Vincristine
Vinca alkaloid that prevents microtubule assembly can cause cell arrest at metaphase
Testicular cancer, Kaposi sarcoma
M phase
Vinblastine
Inhibits DNA gyrase, S cycle specific
Lung cancer, non Hodgkin lymphoma
Can cause alopecia
Etoposide
Taxane, M phase
Interferes with mitotic spindle and prevents microtubule assembly
Used for advanced breast and ovarian CA
Paclitaxel
Docetaxel
Anthracycline anti tumor antibiotic, cell cycle non specific
Can cause dilated cardiomyopathy
Doxorubicin
Most specific for G2 of cell cycle
Bleomycin
Antitumor antibiotic for melanoma and wilms tumor
Actinomycin D
Tyrosine kinase inhibitor
CML
GIST
Imatinib
Monoclonal antibody against HER2-neu
For metastatic breast cancer
Cardiotoxic
Trastuzumab
Monoclonal antibody that inhibits binding of VEGF, which inhibits tumor vascular permeability
For metastatic colon cancer, non small cell lung cancer and renal
Bevacizumab
Monoclonal antibody that binds to CD20 in NHL cells
Rituximab
Monoclonal antibody that binds to EGFR
Colorectal cancer
Cetuximab
Only vitamin that can cure cancer
All trans retinoic acid
All trans retinoic acid is used for
Acute promyelocytic leukemia
