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Pharma > Cancer > Flashcards

Cancer Flashcards

1
Q

Cancer drugs acting on the M phase

A

Vincristine
Vinblastine
Paclitaxel

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2
Q

Cancer drugs acting on the G2 phase

A

Bleomycin

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3
Q

Cancer drugs acting on the S phase

A

CHEM 66

Cytarabine
Hydroxyurea 
Etoposide
Methotrexate 
6- mercaptopurine
6- thioguanine
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4
Q

Rescue drug for methotrexate

A

Leucovorin

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5
Q

Rescue drug of cyclophosphamide

A

MESNA

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6
Q

Rescue drug for doxorubicin

A

Dexrazoxane

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7
Q

Rescue drug for cisplatin

A

Amifostine

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8
Q

Alkylating agent, cell cycle non specific for non Hodgkin lymphoma

Can cause hemorrhagic cystitis

A

Cyclophosphamide

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9
Q

Cyclophosphamide can cause hemorrhagic cystitis because it forms ____ which can cause direct toxicity to the bladder

A

Acrolein

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10
Q

Platinum based alkylating agent, CCNS, used for testicular, ovarian, advanced colon cancer

Nephrotoxic and can cause acoustic nerve damage

A

Cisplatin

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11
Q

Nephrotoxicity of cisplatin can be minimized by forced hydration and administration of this drug

A

Mannitol

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12
Q

Alkylating agent, CCNS for hodgkin and non hodgkin lymphoma

A

Procarbazine

Dacarbazine

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13
Q

Alkylating agent for CML

Bone marrow sparing

A

Busulfan

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14
Q

Drugs causing pulmonary fibrosis

BBBAN Me

A 
Bleomycin
Busulfan
Bromocriptine 
Amiodarone
Nitrofurantoin
Methotrexate
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15
Q

Nitrosourea alkylating agent that is used for brain tumors, highly lipophilic that can cause BBB

A

Carmustine
Lomustine
Bendamustine

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16
Q

Methotrexate inhibits what enzyme?

A

Dihydrofolate reductase

17
Q

Antimetabolite, S Phase specific, DMARD

Used for choriocarcinoma, primary CNS lymphoma, RA, psoriasis, ectopic pregnancy

A

Methotrexate

18
Q

Purine antimetabolite that inhibits de novo purine nucleotide synthesis

For acute leukemias

A

6-Mercaptopurine

6-thioguanine

19
Q

Pyrimidine antimetabolite that inhibits thymidylate synthase, causes thymine less death of cells

Colorectal cancer and skin cancer

A

5-FU

20
Q

Pyrimidine antimetabolite that inhibits ribonucleotide reductase

Used for acute leukemias and CML in blast crisis

A

Cytarabine

21
Q

Most specific drug for the S phase

A

Cytarabine

22
Q

Pyrimidine antimetabolite that inhibits ribonucleotide reductase

For pancreatic cancer

A

Gemtacibine

Capetacibine- prodrug of 5 FU

23
Q

Vinca alkaloid that prevents microtubule assembly can cause cell arrest at metaphase

Acute leukemia, wilms tumor, neuroblastoma

Acts on M phase

A

Vincristine

24
Q

Vinca alkaloid that prevents microtubule assembly can cause cell arrest at metaphase

Testicular cancer, Kaposi sarcoma

M phase

A

Vinblastine

25
Q

Inhibits DNA gyrase, S cycle specific

Lung cancer, non Hodgkin lymphoma

Can cause alopecia

A

Etoposide

26
Q

Taxane, M phase
Interferes with mitotic spindle and prevents microtubule assembly

Used for advanced breast and ovarian CA

A

Paclitaxel

Docetaxel

27
Q

Anthracycline anti tumor antibiotic, cell cycle non specific

Can cause dilated cardiomyopathy

A

Doxorubicin

28
Q

Most specific for G2 of cell cycle

A

Bleomycin

29
Q

Antitumor antibiotic for melanoma and wilms tumor

A

Actinomycin D

30
Q

Tyrosine kinase inhibitor
CML
GIST

A

Imatinib

31
Q

Monoclonal antibody against HER2-neu

For metastatic breast cancer
Cardiotoxic

A

Trastuzumab

32
Q

Monoclonal antibody that inhibits binding of VEGF, which inhibits tumor vascular permeability

For metastatic colon cancer, non small cell lung cancer and renal

A

Bevacizumab

33
Q

Monoclonal antibody that binds to CD20 in NHL cells

A

Rituximab

34
Q

Monoclonal antibody that binds to EGFR

Colorectal cancer

A

Cetuximab

35
Q

Only vitamin that can cure cancer

A

All trans retinoic acid

36
Q

All trans retinoic acid is used for

A

Acute promyelocytic leukemia

Pharma (15 decks)

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