Cancer

Question 1

Cancer drugs acting on the M phase

Answer 1

Vincristine
Vinblastine
Paclitaxel

Question 2

Cancer drugs acting on the G2 phase

Answer 2

Bleomycin

Question 3

Cancer drugs acting on the S phase

Answer 3

CHEM 66

Cytarabine
Hydroxyurea 
Etoposide
Methotrexate 
6- mercaptopurine
6- thioguanine

Question 4

Rescue drug for methotrexate

Answer 4

Leucovorin

Question 5

Rescue drug of cyclophosphamide

Answer 5

MESNA

Question 6

Rescue drug for doxorubicin

Answer 6

Dexrazoxane

Question 7

Rescue drug for cisplatin

Answer 7

Amifostine

Question 8

Alkylating agent, cell cycle non specific for non Hodgkin lymphoma

Can cause hemorrhagic cystitis

Answer 8

Cyclophosphamide

Question 9

Cyclophosphamide can cause hemorrhagic cystitis because it forms ____ which can cause direct toxicity to the bladder

Answer 9

Acrolein

Question 10

Platinum based alkylating agent, CCNS, used for testicular, ovarian, advanced colon cancer

Nephrotoxic and can cause acoustic nerve damage

Answer 10

Cisplatin

Question 11

Nephrotoxicity of cisplatin can be minimized by forced hydration and administration of this drug

Answer 11

Mannitol

Question 12

Alkylating agent, CCNS for hodgkin and non hodgkin lymphoma

Answer 12

Procarbazine

Dacarbazine

Question 13

Alkylating agent for CML

Bone marrow sparing

Answer 13

Busulfan

Question 14

Drugs causing pulmonary fibrosis

BBBAN Me

Answer 14

Bleomycin
Busulfan
Bromocriptine 
Amiodarone
Nitrofurantoin
Methotrexate

Question 15

Nitrosourea alkylating agent that is used for brain tumors, highly lipophilic that can cause BBB

Answer 15

Carmustine
Lomustine
Bendamustine

Question 16

Methotrexate inhibits what enzyme?

Answer 16

Dihydrofolate reductase

Question 17

Antimetabolite, S Phase specific, DMARD

Used for choriocarcinoma, primary CNS lymphoma, RA, psoriasis, ectopic pregnancy

Answer 17

Methotrexate

Question 18

Purine antimetabolite that inhibits de novo purine nucleotide synthesis

For acute leukemias

Answer 18

6-Mercaptopurine

6-thioguanine

Question 19

Pyrimidine antimetabolite that inhibits thymidylate synthase, causes thymine less death of cells

Colorectal cancer and skin cancer

Answer 19

5-FU

Question 20

Pyrimidine antimetabolite that inhibits ribonucleotide reductase

Used for acute leukemias and CML in blast crisis

Answer 20

Cytarabine

Question 21

Most specific drug for the S phase

Answer 21

Cytarabine

Question 22

Pyrimidine antimetabolite that inhibits ribonucleotide reductase

For pancreatic cancer

Answer 22

Gemtacibine

Capetacibine- prodrug of 5 FU

Question 23

Vinca alkaloid that prevents microtubule assembly can cause cell arrest at metaphase

Acute leukemia, wilms tumor, neuroblastoma

Acts on M phase

Answer 23

Vincristine

Question 24

Vinca alkaloid that prevents microtubule assembly can cause cell arrest at metaphase

Testicular cancer, Kaposi sarcoma

M phase

Answer 24

Vinblastine

Question 25

Inhibits DNA gyrase, S cycle specific Lung cancer, non Hodgkin lymphoma Can cause alopecia

Answer 25

Etoposide

Question 26

Taxane, M phase Interferes with mitotic spindle and prevents microtubule assembly Used for advanced breast and ovarian CA

Answer 26

Paclitaxel | Docetaxel

Question 27

Anthracycline anti tumor antibiotic, cell cycle non specific Can cause dilated cardiomyopathy

Answer 27

Doxorubicin

Question 28

Most specific for G2 of cell cycle

Answer 28

Bleomycin

Question 29

Antitumor antibiotic for melanoma and wilms tumor

Answer 29

Actinomycin D

Question 30

Tyrosine kinase inhibitor CML GIST

Answer 30

Imatinib

Question 31

Monoclonal antibody against HER2-neu For metastatic breast cancer Cardiotoxic

Answer 31

Trastuzumab

Question 32

Monoclonal antibody that inhibits binding of VEGF, which inhibits tumor vascular permeability For metastatic colon cancer, non small cell lung cancer and renal

Answer 32

Bevacizumab

Question 33

Monoclonal antibody that binds to CD20 in NHL cells

Answer 33

Rituximab

Question 34

Monoclonal antibody that binds to EGFR Colorectal cancer

Answer 34

Cetuximab

Question 35

Only vitamin that can cure cancer

Answer 35

All trans retinoic acid

Question 36

All trans retinoic acid is used for

Answer 36

Acute promyelocytic leukemia