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Pharma > Coagulation Disorders > Flashcards

Coagulation Disorders Flashcards

1
Q

Platelet activator and powerful vasoconstrictor

A

Thromboxane A2

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2
Q

Potent endothelium derived vasoconstrictor

A

Endothelin

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3
Q

Platelet adhesion is mediated by

A

vWF

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4
Q

What receptor is responsible for platelet adhesion?

A

gp1b

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5
Q

What receptor is responsible for platelet aggregation ?

A

gp2b3a

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6
Q

Proaggregation factors:

A

TXA2
Serotonin
ADP

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7
Q

Anti aggregation factors

A

PGI2- prostacyclin
cAMP
PGE1

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8
Q

Problems with gp1b receptor leads to this disease

A

Bernard-Soulier

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9
Q

Problems with gp2b3a receptor leads to this disease

A

Glansman disease

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10
Q

Factors in intrinsic pathway

A

5,8,9,10,11,12
Prothrombin
Fibrinogen

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11
Q

Factors in extrinsic pathway

A

5,7,10 prothrombin, fibrinogen

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12
Q

Nonselective, irreversible COX inhibitor that reduces TXA2

A

Aspirin
Salsalate
Na salicylate

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13
Q

Associated with Reye syndrome

A

Aspirin

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14
Q

Toxic dose of aspirin

A

150mg/kg

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15
Q

Lethal dose of aspirin

A

500mg/kg

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16
Q

Triad of asprin hypersensitivity

Samter Triad

A

Asthma
Aspirin sensitivity
Nasal polyps

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17
Q

What is the expected acid base abnormality in salicylate poisoning?

A

Respiratory alkalosis with HAGMA

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18
Q

gp2b3a inhibitor used during PCI to prevent thrombosis and adjunct to thrombolysis and ACS

A

Abciximab
Eptifibatide
Tirofiban

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19
Q

Thienopyridine, ADP inhibitor that reduces platelet aggregation

A

Clopidogrel
Ticlopidine
Prasugrel

20
Q

PDE3 inhibitor that increases cAMP in platelets and blood vessels and causes vasodilation

A

Cilostazol

Dipyridamole

21
Q

Antiplatelet drug used for prevention of thromboembolic complications of caridac valve replacement, intermittent claudication

A

Cilostazol

Dipyridamole

22
Q

Contraindicated in heart failure

A

Cilistazol

23
Q

Heparin or Warfarin?

Site of action- liver

A

Warfarin

24
Q

Heparin or Warfarin?

Activates antithrombin III

A

Heparin

25
Q

Heparin or Warfarin?

Monitored by PT INR

A

Warfarin

26
Q

Heparin or Warfarin?

Monitored by PTT

A

Heparin

27
Q

Heparin or Warfarin?

Can be used in pregnancy

A

Heparin

28
Q

Heparin or Warfarin?

Slow onset (days)

A

Warfarin

29
Q

Antidote for heparin

A

Protamine sulfate

30
Q

Antidote for warfarin

A

Vitamin K

31
Q

Anticoagulant thay can cause osteoporosis with prolonged use

A

Heparin

32
Q

Indirect thrombin inhibitor that binds antithrombin III on factor 10a
Does not require monitoring

A 
Enoxaparin
Danaparoid
Fondaparinux
Dalteparin
Tinzaparin
33
Q

Direct thrombin inhibitor that inhibits its enzymatic action used in heparin induced thrombocytopenia

A

Lepirudin
Dabigatran
Argatroban

34
Q

Direct thrombin inhibitors should be monitored with

A

PTT

35
Q

Oral direct factor 10a inhibitor used in prevention of venous thromboembolism and prevention of stroke in patients with AF

A

Rivaroxiban

Apixaban

36
Q

Rapid onset and shorter half life than warfarin
No monitoring required
Used especially after hip or knee surgery

A

Rivaroxiban

Apixaban

37
Q

Side effect of warfarin

A

Warfarin induced skin necrosis
Protein C and S deficiency
Teratogen

38
Q

How to avoid skin necrosis in warfarin?

A

Anticoagulant overlap with heparin

39
Q

Cytochrome P450 inducers

Ethel Booba takes Phen Phen and Refuses Greasy Carb Shakes

A 
Ethanol
Barbiturates 
Phenytoin 
Rifampicin
Griseofulvin
Carbamazepine
Smoking/ St. John's Wort
40
Q

Cytochrome P450 inhibitors

Inhibitors Stop Cyber Kids from Eating GRApefruit Q

A 
Isoniazid 
Sulfonamides
Cimetidine
Ketoconazole
Erythromycin 
Grapefruit juice
Ritonavir
Amiodarone
Quinidine
41
Q

Thrombolytic (tissue plasminogen activator analog) that converts plasminogen to plasmin

A 
Alteplase
Anistreplase
Streptokinase
Reteplase
Tenecteplase
Urokinase
42
Q

Antidote for streptokinase

A

Aminocaproic acid

43
Q

Contraindications to thrombolysis

A 
Cerebral hemorrhage at any time
Cerebrovascular event within the past year
Marked HTN
suspicious aortic dissection 
Active internal bleeding
44
Q

Competitively inhibits plasminogen activation by inhibiting tPA

A

Tranexamic acid

45
Q

Prothrombotic contraindicated in DIC

A

Tranexamic acid

46
Q

ADH agonist that increases factor 8 activity on patients with mild hemophilia A or vWF

A

Desmopressin

47
Q

Where does desmopressin act?

A

Vasopressin V2 receptor

Pharma (15 decks)

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