Endocrine

Question 1

Somatostatin analog used for acromegaly, pituitary adenoma, and variceal bleeding

Answer 1

Octreotide

Question 2

GnRH analog for ovarian suppression, endometriosis, myoma uteri

Can cause temporary exacerbation of precocious puberty or prostate CA

Answer 2

Leuprolide

Question 3

GnRH antagonist to prevent premature LH surge during controlled ovarian hyperstimulation

Answer 3

Ganirelix

Question 4

Dopamine agonist used for hyperprolactinemia

Answer 4

Bromocriptine

Question 5

ADH antagonist used for SIADH

Answer 5

Conivaptan

Question 6

Levothyroxine’s effect for hypothyroidism can be seen how many weeks after therapy?

Answer 6

6-8 weeks

Question 7

Medical emergency representing the end state of untreated hypothyroidism

Answer 7

Myxedema coma

Question 8

Inhibits peripheral conversion of T4-T3

Answer 8

PTU

Question 9

Drug of choice for hyperthyroid pregnant patients

Answer 9

PTU

Question 10

Thioamide that blocks iodine organification

Answer 10

Methimazole

Question 11

Prenatal exposure to methimazole can cause

Answer 11

Aplasia cutis congenita

Question 12

Symptoms preceding agranulocytosis

Answer 12

Sore throat

Fever

Question 13

Prevents radiation induced thyroid damage

Answer 13

Potassium iodide

Lugol’s solution

Question 14

Ingestion of iodine causes hypothyroidism

Answer 14

Wolf Chaikoff effect

Question 15

Ingestion of iodine causes hyperthyroidism

Answer 15

Jod Basedow phenomenon

Question 16

Beta blocker that inhibits peripheral conversion of T4 to T3

Answer 16

Propranolol

Question 17

Anti arrhythmic that can cause thyroid disease

Answer 17

Amiodarone

Question 18

Mineralocorticoid used for addison disease, CAH and adrenal replacement therapy

Answer 18

Fludrocortisone

Deoxycorticosterone

Question 19

Glucocorticoid synthesis inhibitor that inhibits desmolase blocking conversion of cholesterol to pregnenolone

Used for breast cancer and cushing syndrome
Abused by body builders

Answer 19

Aminoglutethimide

Question 20

Glucocorticoid synthesis inhibitor and an azole antifungal

Answer 20

Ketoconazole

Question 21

Drug of choice for pregnant patients with Cushing

Answer 21

Metyrapone

Question 22

Synthetic estrogen used for atrophic vaginitis

Can have clear cell vaginal adenocarcinoma in daughters of mothers who took this drug

Answer 22

Diethylstilbestrol

Question 23

Activates progesterone receptors

For HRT and contraception
Prevents estrogen induced endometrial cancer

Answer 23

Norgestrel

Question 24

Progestin used as appetite stimulant

Answer 24

Megestrol

Question 25

Selective estrogen receptor modulator (SERM) that is used for hormone sensitive breast cancer

Answer 25

Tamoxifen

Question 26

Tamoxifen reduces the risk for what type of cancer?

Answer 26

Endometrial

Question 27

SERM that has estrogen agonist effects in liver and bone Used in osteoporosis

Answer 27

Raloxifene

Question 28

SERM used for induction of ovulation Can cause multiple pregnancy

Answer 28

Clomiphene

Question 29

Estrogen synthesis inhibitor by inhibiting aromatase Used for breast cancer and precocious puberty

Answer 29

Anastrozole Letrozole Exemestane

Question 30

Ovarian inhibitor, partial agonist of progestin and androgen receptors Used for endometriosis, fibrocystic disease Can cause weight gain, acne, hirsutism

Answer 30

Danazol

Question 31

Androgen antagonist for prostate cancer and surgical castration

Answer 31

Flutamide Bicalutamide Nilutamide

Question 32

Early morning hyperglycemia: When the evening dose of intermediate insulin is high, hypoglycemia develops around 3am Counter regulatory hormones are produced resulting to hyperglycemia pre breakfast

Answer 32

Somogyi effect

Question 33

Treatment for somogyi effect

Answer 33

Decrease dose of evening insulin

Question 34

Early morning hyperglycemia: When the evening dose of intermediate insulin is low, hyperglycemia both at 3am and 7am

Answer 34

Insulin waning

Question 35

Treatment for waning of insulin dose

Answer 35

Increase dose of evening insulin

Question 36

Early morning hyperglycemia: Insulin sensitivity becomes low between 6 and 7 am due to growth hormone spike Mild hypoglycemia in the morning but 3am glucose is normal

Answer 36

Dawn phenomenon

Question 37

Most physiologic strategy in insulin therapy

Answer 37

Basal bolus

Question 38

Secretion of PTH is dependent on the concentration of this ion in the blood

Answer 38

Free ionized calcium