Cardiac Flashcards
Inhibits Na-Cl transporter in the distal convoluted tubule
Moderate diuresis and reduced excretion of calcium
Hydrochlorothiazide
Chorthalidone
Indapamide
Metolazone
Side effects of thiazides
Hyper GLUC Glycemia Lipidemia Uricemia Calcemia
Inhibits Na-K-2Cl transporter in the thick ascending loop of Henle
Furosemide
Bumetanide
Torsemide
Ethacrynic acid
DOC for acute heart failure
Furosemide
Sympathetic outflow blocker that activates a2 adrenergic receptors to decrease sympathetic outflow
Clonidine
Clonidine must be tapered before discontinuing to avoid
Rebound hypertension
Antidote for Clonidine
Phentolamine
Sympathetic outflow blocker used for preeclampsia
Methyldopa
Guanabenz
Guanfacine
Side effects of Methyldopa
Sedation
Hemolytic anemia
Positce Coombs test
Ganglion blocker that competitively blocks Nn nicotinic Ach receptors
Hexamethonium
Trimethaphan
Mecamylamine
Nerve terminal blocker that irreversibly blocks the vesicular monoamine transporter (VMAT) of NE
Used for hypertension (obsolete)
Reserpine
Side effect of reserpine
Suicidal ideation
Rebound suicide
Nerve terminal blocker that inhibits vesicular release of NE from the presynaptic neuron
Used for hypertension (obsolete)
Guanethidine
Guanadrel
Alpha 1 selective antagonist for BPH and hypertension
Prazosin
Doxazosin, terazosin, tamsulosin, silodosin, alfuzosin
Side effect of alpha 1 selective antagonist
1st dose orthostatic hypotension
Alpha 1 blocker most selective for prostatic smooth muscle
Tamsulosin
Which anti hypertensive can cause bronchospasm, erectile dysfunction and mask symptoms of hypoglycemia in diabetics?
Beta blockers
Which beta blocker has combined alpha and beta blockade that can be used for pheochromocytoma?
Carvedilol and Labetalol
What drugs are used to control blood pressure in pheochromocytoma?
Phentolamine
Phenoxybenzamine
Labetalol
Vasodilator that alters intracellular calcium metabolism, relaxes arteriolar smooth muscle, vasodilation and decreased afterload
Hydralazine
Medications that cause drug induced lupus
HIPP to have lupus Hydralazine Isoniazid Procainamide Penicillamine
Vasodilator that opens K channels in vascular smooth muscle causing hyperpolarization and muscle relaxation
Minoxidil
Diazoxide
Side effect of minoxidil that is why it is used for alopecia
Hypertrichosis
Non dihydropyridine calcium channel blockers
Verapamil
Diltiazem
Used for supraventricular tachycardia in OPD setting
Verapamil
Diltiazem
Can cause gingival hyperplasia, heart failure, AV block
Diltiazem
Verapamil
Dihydropyridine calcium channel blocker used for angina and HTN
Nifedipine Amlodipine Isradipine Clevidipine Nisoldipine
Parenteral Vasodilator that relaxes smooth muscle by increasing cGMP
Nitroprusside
Which vasodilator can cause cyanide toxicity?
Nitroprusside
Dopamine agonist (D1) that causes dilation of afferent and efferent arterioles for 10 mins.
Fenoldopam
Drug of choice for chronic heart failure
ACE inhibitors
ARBs
Anti hypertensive that can cause cough, hyperkalemia
Captopril
Enalalril
Benazepril, Fosinopril, Quinapril, Ramipril, Trandolapril, Moexipril
Anti hypertensive that slows ventricular remodelling and increases survival in heart failure
ACE inhibitors
Anti hypertensive that delays progression of diabetic nephropathy
Renoprotective
ACE inhibitors
ARBs
Why do patients taking ACE and ARBs develop hyperkalemia?
Reduces aldosterone levels that causes potassium retention
Renin antagonist that prevents conversion of angiotensinogen to angiotensin 1
Aliskiren
Treatment for malignant hypertension
Vasodilators (nitroprusside, fenoldopam or diazoxide)
Diuretics (furosemide)
Beta blockers
Ultra short acting nitrite used for cyanide poisoning
Amyl Nitrite
Which portion of the electron transport chain is affected by cyanide?
Complex IV (cytochrome oxidase)
Antidote for cyanide poisoning
Inhaled amyl nitire
IV Na nitrite
IV sodium thiosulfate
Disease due to exposure to nitrites
Alternating tolerance and loss of tolerance over the weekend
Monday disease
Short acting nitrate that release NO, increases cGMP and relaxes smooth muscle
Nitroglycerin
Isosorbide dinitrate, mono nitrate
Imdur
Nitrates can cause dangerous hypotension when given with
PDE inhibitors (sildenafil)
Works by inhibiting conversion of cGMP to inactive GMP
Phosphodiesterase inhibitors
Nitrates can cause headaches due to
Meningeal blood vessel dilation
DOC for prinzmetal angina
Diltiazem
Drug that can cause Raynaud
Phenomenon
Diltiazem
Drugs that can cause gingival hyperplasia
Nako Ca Pangit Vera ng gingiva mo
Nifedipine
Cyclosporine
Phenytoin
Verapamil
Drug used for angina prophylaxis
Beta blockers
Cytoprotective agent, metabolism modifier used for angina, tinnitus, dizziness
Trimetazidine
Inhibits beta oxidation of fatty acids by inhibiting thiolase which enhances glucose oxidation. Prevents decrease in ATP in ischemic states
Trimetazidine
Metabolism modifier that can cause EPS, gait instability, restless leg syndrome
Interacts with MAO inhibitors
Trimetazidine
Metabolism modifier that reduces a late, prolonged Na current in myocardial cells that decreases intracellular Ca and cardiac force
Ranolazine
Metabolism modifier that produces QT prolongation
Ranolazine
Metabolism modifier that works in the funny Na channel in the SA node that decreases hyperpolarization and heart rate
Ivabradine
Cardiac glycoside that inhibits Na-K ATPase and increases cardiac contractility due to increased intracellular Ca
Digoxin
Arrhythmogenesis of digoxin can be increased by
Hypokalemia
Hypomagnesemia
Hypocalcemia
Cardiac glyoside that has narrow therapeutic index and can cause visual changes
Digoxin
Drugs that have narrow therapeutic index
WALA na Cyang PaPa VasTeD na Warfarin Aminoglycosides Lithium Amphotericin B Carbamazepine Phenobarbital Phenytoin Vancomycin Theophylline Digoxin
Antidote for digitalis toxicity
Lidocaine
Beta 1 selective agonists useful in Acute heart failure
Dobutamine
Dopamine
Drugs used for ACUTE heart failure
Furosemide
Beta agonists and vasodilator (if severe)
Drugs used for CHRONIC heart failure
Diuretics(loop and spironolactone)
Plus
ACE inhibitor and beta blocker if tolerated
Digitalis if with prominent systolic dysfunction
Phosphodiesterase inhibitors that increase cAMP by inhibiting its breakdown
Increases intracellular Ca and causes vasodilation
Milrinone
Inamrinone
Drugs that have no value in CHF
Calcium channel blockers
Polymorphic ventricular tachycardia, often displaying waxing and waning QRS amplitude
Associated with long QT syndrome
Torsades de Pointes
Class 1 antiarrhythmics
Sodium channel blockers
Class 2 antiarrhythmics
Beta blockers
Class 3 antiarrhythmics
Potassium channel blockers
Class 4 antiarrhythmics
Calcium channel blockers
This class of anti arrhythmic have local anesthetic activity and act on phase 0 of the cardiac action potential
Class 1 (Na channel antagonist)
Subclass of Class 1 antiarrhythmics that prolong the AP duration
Class 1A
Subclass of Class 1 antiarrhythmics that shorten the AP duration
Class 1B
Subclass of Class 1 antiarrhythmics that have no effect on the AP duration
Class 1C
Least arryhthmogenic among all antiarrhythmics
Class 1
Most selective Class 1 anti arrhythmics
Class 1B
This class 1 antiarrhythmic has significant effects on sodium channels in ischemic tissue nut negligible effect on normal cells
Class 1B
This group of anti arrhythmics slow or block conduction in ischemic and depolarized cells and slow or abolish abnormal pacemakers
Class 1
Anti arrhythmic that has class 1A action and can cause refractory arrhythmia
Amiodarone
Class 1A anti arrhythmic that is used in arrhythmias following MI
Can cause lupus like syndrome
Procainamide
Class 1A anti arrhythmic that has marked anti muscarinic effects and can cause heart failure
Disopyramide
Class 1A anti arrhythmic that is also used for malaria
Quinidine
Anti arrhythmic that reduces clearance of digoxin
Quinidine
Class 1A anti arrhythmic that can cause cinchonism ( headache, vertigo, tinnitus) and autoimmune reactions (ITP)
Quinidine
Class 1A anti arrhythmics
I am the Queen who Proclaimed Diso’s Pyramid
Quinidine
Procainamide
Disopyramide
Treatment for class 1A anti arrhythmic overdose
Sodium Lactate
Class 1B anti arrhythmics selectively affects what tissue?
Ischemic or depolarized Purkinje and ventricular tissue
DOC for ventricular arrhythmias post MI and digoxin induced arrhythmias
Lidocaine
Class 1B anti arrhythmic that can cause agranulocytosis
Tocainide
Least cardiotoxic among conventional anti arrhythmics
Lidocaine
Drugs that can cause agranulocytosis
CCCAPPIT Clozapine Co-trimoxazole Colchicine Aminopyrine Phenylbutazone PTU Indomethacin Tocainide
Class 1B anti arrhythmics
I Buy Mexican Tacos from Lily
Mexiletine
Tocainide
Lidocaine
Most proarrhythmogenic class of anti arrhythmics
Class 1C
Class 1 anti arrhythmics that can be used for refractory arrhythmias
Flecainide
Propafenone
Encainide
Moricizine
Class 1 anti arrhythmics contraindicated for post MI
Class 1C
Class 1C anti arrhythmics
Chicken ay Pagkain for Enrico
Propafenone
Flecainide
Encainide
Anti arrhythmics used for WPW
Procainamide
Amiodarone
Anti arrhythmic used for all types of arrhythmias and acute phase of MI
Class 1A
Class 1 anti arrhythmics used for acute ventricular arrhythmia especially for post M
Atrial arrhythmias due to digitalis
Class 1B
Class 1 anti arrhythmic used for refractory arrhythmias
Class 1C
Anti arrhythmics that act on phase 4 of the cardiac action potential and causes prolonged PR interval
Class 2
Class 1B anti arrhythmic used for acute perioperative and thyrotoxic arrhythmias and SVT
Esmolol
Class 3 anti arrhythmic act on which phase of action potential
Phase 3
Class of antiarrhythmic that causes prolonged AP duration and can also cause torsades de pointes
Class 3
Class 3 anti arrhythmic that is used for treatment and prophylaxis of atrial fibrillation
Dofetilide
Ibutilide
Class 3 anti arrhythmic that also has class 2 effects
Sotalol and Amiodarone
Class 3 anti arrhythmic for refractory arrhythmia
Amiodarone
Longest half life and most efficacious of all anti arrhythmics
Amiodarone
Anti arrhythmic that can cause microcrystalline deposits in cornea and skin, thyroid dysfunction and paresthesia, tremors
Amiodarone
Anti arrhythmic that cause a state and use dependent selective depression of calcium currents
Prolonged PR interval
Class 4
Class 4 anti arrhythmics used for supraventricular tachycardia
Verapamil
Diltiazem
Miscellaneous anti arrhythmic that is the DOC for paroxysmal supraventricular tachycardia
Adenosine
Anti arrhythmic that prolongs PR interval
Class 2 and 4
Anti arrhythmic that prolongs QT interval
Class 3
Anti arrhythmic that prolongs QRS duration
Class 1C
Decreased levels of this ion can cause arrhythmia
Potassium
Diuretic used for mountain sickness
Acetazolamide
Brinzolamide
Dichlorphenamide
Acetazolamide and cause this type of acid base disorder
Normal anion gap metabolic acidosis
Acid-zolamide
This drug decreases effect of loop diuretics
NSAIDS
Adverse effects associated with loop diuretics
OH DANG Ototoxicity Hypokalemia Dehydration Allgery to sulfa Nephritis Gout
Diuretics used for renal calcium stones
Thiazides
Spironolsctone can cause
Gynecomastia
Diuretics that are steroid inhibitors of cytoplasmic aldosterone receptors in cortical collecting duct and reduces K excretion
Spironolactone
Eplerenone
Spironolactone can cause this type of acid base disorder
Hyperchloremic metabolic acidosis
Potassium sparinf diuretic that reduces the progression of DM nephropathy and reduces mortality post MI
Eplerenone
Postassium sparing diuretic that inhibits ENaC, reduces Na reabsorption and K excretion
Amiloride
Triamterene
Drugs that have antiandrogenic effects
Some Drugs Create Awesome Knockers Cimetidine Spironolactone Ketoconazole Digoxin
Major site of action of Mannitol
PCT
ADH agonist that activates insertion of aquaporin water channels in collecting tubule and cause vasoconstriction
Desmopressin, Vasopressin
ADH antagonist with unknown mechanism that is used for SIADH
Conivaptan, tolvaptan, demeclocyline
May occur with rapid correction of hyponatremia
Central pontine myelinosis