Schizophrenia Flashcards

1
Q

neuro disregulation of schizophrenia

A

mesocorticolimbic circuit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

must have 2 of 5 of these symptoms (and 1 from the first three)

A
delusions
hallucinations
disorganized speech
grossly disorganized or catatonic behaior
negative sxs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

must also have

A

social/occupational dysfunction
duration of 6 months of continuous symptoms
no schizoaffective and mood disorder
no substance abuse or othe rmedical issue
need to exclude autism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

relation to autism

A

autism has disorganized speech and negative symptoms, but does not have prominent hallucinations or delusions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

somatic delusion

A

feet mechanical, device implanted

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

nihilistic delusion

A

world coming to an end

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Schizophreniform Disorder

A

sitting on the tipping point to schizophrenia

duration of 1-6 months with a 50% chance of going on to develop schizophrenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

schizoaffective disorder

A

major depressive, manic, or mixed episodes concurrent with first criteria for schizo
–mood symptoms present for majority of total duration/delusions for 2+ weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

subtypes of schizoaffective disorder

A

bipolar

depressive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

delusional disorder

A

one or more delusions more than 1x month
criteria A not met
mood episodes brief compared to delusional periods

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

attenuated psychosis syndrome

A

intact reality testing- but either delusions, hallucinations, or disorganized speech
more than once/week for past month
suddenly distressing and disabling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

schizo epi

A

1%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

when does schizo begin?

A

typically teens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which episode is most responsive to treatment

A

first

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

how many relapses until chronic schizo?

A

3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

women as compared to men

A

better premorbid function, estrogen is neuroprotective because inhibits D2 receptors

17
Q

3 phases of schizo

A

1) prodromal
2) active
3) residual

18
Q

prodromal phase

A

social, cognitive deficits may precede activity phase by many years

19
Q

active phase

A

full syndrome, typically 3-4 decades (teens, 20s, 50s)

20
Q

residual phase

A

1/3 remission, 1/3 attenuation of symptoms in older years, stages of illness propose

21
Q

suicide in schizo

A

20-40% attempt, 10% complete

22
Q

what med reduces risk of suicide and violence?

23
Q

life expectancy schizo

A

10-30 years

24
Q

percentage of schizos that smoke

25
what neuroanatomy fnding?
dendritic spine density on deep layer 3 pyramidal neurons | --means decrease excitability to DLPFC layer 3 pyramidal cells--> dec cognitive ability
26
functional brain abnormalities
diffuse cerebral dysfunction (esp prefrontal and medial temporal)
27
neurochemical brain abnormalities
DA hypersensitivity in MESOLIMBIC DA hypoactivity in MESOCORTICAL glutamate NMDA 5ht, GABA, NE, Ach
28
mesolimbic pathway
midbrain VTA-->Nucleus accumbens, olfactory tubercle, and limbic system *overactivity due to postive symptoms
29
mesocortical pathway
midbrain VTA-->frontal cortex | *learning and memory; reduce associated with negative symptoms
30
nigostriatal pathway
control of movement
31
tuberoinfundibular pathway
projects from hypothalamus to anterior pituitary gland and controls prolactin secretion
32
if you treat the movement and prolactin pathway...
causes worsening of positive and negative symptoms
33
NMDA antagonists
causes apoptosis/neuro degen due to excitotoxicity
34
PCP and ketamine
neurodegen because they are NMDA antagonists
35
atypical antipsychotics
treat schizo because inhibit neurodegen assocaited with excitotoxicity and apoptosis
36
first generation antipsychotics
F2 antagonists (chlorpromazine, haloperidol)
37
second generational antipsychotics
clozapine | G2, 5HT2 antag
38
antipsychotics have limited improvement in
negative and cognitive symptoms
39
antispyschot drugs help
psychotic (positive) symptoms, agitation, disorganizaiton