Mood Disorders

Question 1

MDD requires 1 of these 2

Answer 1

depressed mood

anhedonia

Question 2

the other diagnostic criteria is

Answer 2

5 or more of the second cateogry in greater than 2 weeks

Question 3

3 associated symptoms of MDD and which one isnt common

Answer 3

anxiety
somatization
psychosis*

Question 4

lifetime prevalence MDD

Answer 4

17%

Question 5

MDD is the #__ cause of years lost due to disability and #___ contributer to overall health burden

Answer 5

1,3

Question 6

more than ___% of suicide happens in MDD patients

Answer 6

60

Question 7

leading cause of death in US

Answer 7

MDD

Question 8

atypical MDD

Answer 8

improved moods with positive events

Question 9

Melancholic MDD

Answer 9

among the most severe form

Question 10

Psychotic MDD

Answer 10

include psychosis

Question 11

catatonic MDD

Answer 11

immobile

Question 12

post-partum MDD

Answer 12

after pregnancy

Question 13

chronic MDD

Answer 13

recurrent

Question 14

untreated episodes of depression generally last

Answer 14

4-6 months

Question 15

major dysthmic disorder

Answer 15

depressed mood everyday for >2 years, no more than 2 months symptom free
associated with >2 symptoms

(chronic, but less symptoms)

Question 16

dysthmic disorder and m:f prevalence

Answer 16

equal male to female

Question 17

remission with dysthimic

Answer 17

less than 10% per year

Question 18

risk of suicide in dysthmici

Answer 18

equal to or greater than MDD

Question 19

mania/hypomanic episodes

Answer 19

three or four of symptoms

Four if irritable

Question 20

mania

Answer 20

symptoms >1 week, significant dysfunction

Question 21

hypomania

Answer 21

symtoms >4 days; limited dysfunction

Question 22

mixed

Answer 22

mania+ depressive symptoms>1 week; significant dysfunction

Question 23

Bipolar I disorder (3)

Answer 23

at least one manic or mixed episode

no need for prior depressive episode

more servere illness than BPII and easier to diagnose

Question 24

BP II disorder (3)

Answer 24

at least one previous major depressive episode

at least one hypomanic episode

less severe than BP I; difficult to diagnose

Question 25

Cyclothymia (4)

Answer 25

fluctuating minor depressive, hypomanic episodes no prior MDD, manix, or mixed episodes over 2 year period, no symptom free period >2 months after 2years, BPI or BP2 may develop

Question 26

BID prevalence

Answer 26

1%, men = women

Question 27

BIID prevalence

Answer 27

0.5%, women > men

Question 28

3 phases of bipolar treatment

Answer 28

antidepressants antimanic maintenance/prevention of episodes

Question 29

5 options for mood stabilizing drugs

Answer 29

``` Lithium** valproic acid/depakote carbamazepine (tegretol) lamotrigine (lamictal)--may not prevent mania; no acute effect atypical antipsychotics ```

Question 30

ECT

Answer 30

generalized cortical seizure induced treatments 2-3xs per week for total 6-15 tx 50-70% remission rates

Question 31

surgical approaches

Answer 31

white matter disconnection: 22-75% efficacy | TMS/rTMS-50% efficacy

Question 32

TMS/rTMS

Answer 32

non-invasive technique for generating current in cortex and modulating neural network activity daily treatments lasting about an hour; 15-30 tx risk of seizure

Question 33

slow rTMS

Answer 33

facilitate long term depression

Question 34

fast rTMS

Answer 34

facilitate long-term potentiation

Question 35

vagus nerve stimulation efective in

Answer 35

30-40% patients

Question 36

DBS targets

Answer 36

sub-collaosal cingulate- activity goes down when responding to treatment 64% feel better

Question 37

other targets MDD

Answer 37

inferior thalamic peduncle, lateral habenula

Question 38

OCD indicated

Answer 38

subthalamic nucleus

Question 39

Tourette's located

Answer 39

centromedian nucleus of thalamus, internal globus pallidus

Question 40

Addictions

Answer 40

NA