Pharm of Substance Abuse Flashcards
Opium
fluid obtained from the poppy plant
Opiate
substance derived from opium
opiod
substance with morphine-like actions; synthetic or semi-synthetic
heroin is a
pro-drug–>6MAM–>MS
not bioavailable
rapidly penetrates BBB
Buprenorphin
partial opioid agonist-ceiling effect low abuse potential lower level physical dependence less opioid effect as compared to methadone safety in overdose quantities
suboxone has
poor bioavailability- sublingual
affinity
strength with which a drug physically binds to a receptor
Buprenorphine’s affinity
very strong, will displace full agonists like heroin or methadone
NOT the same as receptor activation
dissociation
speed (slow or fast) of disengagement or uncoupling of a drug from the receptor
Bu’s dissociation
slow- stays on for long time and blocks heroin/methadone’s action
treatment for opiate overdose
narcan
classic triad of oopiate overdose
miosis
coma
resp depression
early opiate withdrawal
lacrimination yawning rhinorhea sweating anxiety/doom
middle phase opiate withdrawal
restless sleep dilated pupils anorexia gooseflesh irritability tremor
late phase opiate withdrawal
increase in HR and BP nausea, vomiting, ab cramps depression weakness bone pain
