Mania Flashcards

0
Q

lithium also works on

A

headaches esp cluster headache

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1
Q

monotherapy with antidepressants in bipolar patients

A

can ppt mania

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2
Q

VD lithium

A

equal to body water, anything that reduces body water volume–>toxic
increase
increse in circulating lithium levels

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3
Q

toxicity/side effects lithium

A

biggest- nausea, weight gain
less common- nephrogenic Diabeties insipidus
tremor, cognitive slowing, drowsiness

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4
Q

interactions lithium

A

drugs that change tbw- diuretics, aceinhibitors, ca channel blcokers

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5
Q

pregnancy with lithium

A

risk factor D

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6
Q

black box warning lithium

A

very narrow therapeutic window- never double up

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7
Q

valproic acid class

A

anti-convulsant

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8
Q

pharmacodynamics valproic acid

A

increase GABA effects–>decrease glutamate/NMDA-mediated excitation, block channels

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9
Q

valproic acid/depakote side effects

A

potential for severe impact on liver
polycystic ovary syndrome
hair loss

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10
Q

black box warning depakote/valproic acid

A

hepatotoxicity
teratogen
pancreatitis

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11
Q

carbamazepine drug class

A

anticonvulsant for focal and secondary generalized seizures
mood stabilizer for BPD
pain mod for neuropathic pain

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12
Q

pharmacodynamics

A

Na channel sin neuron membrane decrease firing therefore decrease seizure

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13
Q

toxicity/side effects carbamazepine

A

drowsiness, headaches, migraines, motor coordination impairment and/or upset stomach, weight gain
aplstic anemia! derm skin problems

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14
Q

pregnancy carbamazepine

A

class D

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15
Q

lamotrigine drug class

A

anti-convulsant, mood stabilizer

16
Q

lamotrigine is really good because

A

been show to act as a mood stabilizer and antidepressant- good to add to lithium with less weight gain

17
Q

pharmacodynamics lamotrigine

A

unclear mechanisms- Na channel

18
Q

toxicity/side effects of lamotrigine

A

serious skin rashes (toxic epidermal necrosis)

fever, fatigue, somnolence, vertigo, ataxia

19
Q

interactions lamotrigine

A

fewer than any other!!

20
Q

oxacarbezine class

A

anticonvulsant

21
Q

pharmacodynamics

A

same as carbazepine- na channels, but with less side effects

22
Q

toxicity of oxacarbazepine

A

all related to decraese Na levels

hypnatremia (test Na if severe fatigue)

23
Q

special considerations oxacarbazepine

A

depression

behavior changes suicidality

24
combo of atypical antispychotic and lithium
better but weight gain and sedation make it unappealing
25
how to treat when mania decreases
taper off of atypical antipsychotic when mania decerases and effective and safe level of mood stabilizer in blood