Mania

Question 0

lithium also works on

Answer 0

headaches esp cluster headache

Question 1

monotherapy with antidepressants in bipolar patients

Answer 1

can ppt mania

Question 2

VD lithium

Answer 2

equal to body water, anything that reduces body water volume–>toxic
increase
increse in circulating lithium levels

Question 3

toxicity/side effects lithium

Answer 3

biggest- nausea, weight gain
less common- nephrogenic Diabeties insipidus
tremor, cognitive slowing, drowsiness

Question 4

interactions lithium

Answer 4

drugs that change tbw- diuretics, aceinhibitors, ca channel blcokers

Question 5

pregnancy with lithium

Answer 5

risk factor D

Question 6

black box warning lithium

Answer 6

very narrow therapeutic window- never double up

Question 7

valproic acid class

Answer 7

anti-convulsant

Question 8

pharmacodynamics valproic acid

Answer 8

increase GABA effects–>decrease glutamate/NMDA-mediated excitation, block channels

Question 9

valproic acid/depakote side effects

Answer 9

potential for severe impact on liver
polycystic ovary syndrome
hair loss

Question 10

black box warning depakote/valproic acid

Answer 10

hepatotoxicity
teratogen
pancreatitis

Question 11

carbamazepine drug class

Answer 11

anticonvulsant for focal and secondary generalized seizures
mood stabilizer for BPD
pain mod for neuropathic pain

Question 12

pharmacodynamics

Answer 12

Na channel sin neuron membrane decrease firing therefore decrease seizure

Question 13

toxicity/side effects carbamazepine

Answer 13

drowsiness, headaches, migraines, motor coordination impairment and/or upset stomach, weight gain
aplstic anemia! derm skin problems

Question 14

pregnancy carbamazepine

Answer 14

class D

Question 15

lamotrigine drug class

Answer 15

anti-convulsant, mood stabilizer

Question 16

lamotrigine is really good because

Answer 16

been show to act as a mood stabilizer and antidepressant- good to add to lithium with less weight gain

Question 17

pharmacodynamics lamotrigine

Answer 17

unclear mechanisms- Na channel

Question 18

toxicity/side effects of lamotrigine

Answer 18

serious skin rashes (toxic epidermal necrosis)

fever, fatigue, somnolence, vertigo, ataxia

Question 19

interactions lamotrigine

Answer 19

fewer than any other!!

Question 20

oxacarbezine class

Answer 20

anticonvulsant

Question 21

pharmacodynamics

Answer 21

same as carbazepine- na channels, but with less side effects

Question 22

toxicity of oxacarbazepine

Answer 22

all related to decraese Na levels

hypnatremia (test Na if severe fatigue)

Question 23

special considerations oxacarbazepine

Answer 23

depression

behavior changes suicidality

Question 24

combo of atypical antispychotic and lithium

Answer 24

better but weight gain and sedation make it unappealing

Question 25

how to treat when mania decreases

Answer 25

taper off of atypical antipsychotic when mania decerases and effective and safe level of mood stabilizer in blood