Dementia

Question 0

Major neurocognitive disorder

Answer 0

1 or more significant cognitive impairments

interfering with daily functioning

Question 1

freq of 65+ year olds in 2030

Answer 1

1 in 5

dementia is an epidemic!

Question 2

minor neurocognitive disorder

Answer 2

1 or more modest cognitive impairment

does not interefe with daily functioning

Question 3

5 types of major neurocognitive disorder types

Answer 3

alzheimers
vascular disease
frontotemporal lobar degeneration
lewy body disease
parkinson's

Question 4

6 cognitive domains

Answer 4

attention
executive function
memory
language
perceptual motor ability
social cognition

Question 5

risk factors of alzheimers

Answer 5

age (primary--risk doubles veery 5 years after 65)
head trauma
low education
female
medial- CV risk factors
genetics

Question 6

age 85

Answer 6

risk nearly 50%

Question 7

genetics in alz

Answer 7

APPOE gene on E4 of 19 (late onset)
APP gene on chrom 21 (DS)
presenelin-1 on chrom 14
presenelin-2 on chrom 1 (early onset)

Question 8

biology behind alz

Answer 8

accumulation of AB amyloid protein
to do this APP must be cut by two enzymes- beta and gama secretase
presenilin is responsible for this

Question 9

ADLs vs iADLs

Answer 9

basic ADLs- primary function

iADLs are what is lost first and if you dont have them its ok

Question 10

vascular disease

Answer 10

stepwise decline
executive fx and attention decline first
memory, mildly

Question 11

frontotemporal lobar disease

Answer 11

change in behavior/personality
speech/language
cognitive

Question 12

lewy body disease

Answer 12

COGNITIVE IMPAIRMENT
fluctuation in alertness
visual hallucinations
parkinsonism

Question 13

AD meds

Answer 13

cholinesterase inhibitors
donepezil
rivastigmine
galantamine
mematine

Question 14

Pharm interventions

Answer 14

only slow down progression, but do NOT stop or reverse neurodegen (buys you 6-9 months)