Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PSYCH > Antidepressants > Flashcards

Antidepressants Flashcards

You may prefer our related Brainscape-certified flashcards:
Psychology 101 flashcards GRE® Psychology flashcards
1
Q

What do monoamines do?q

A

NOT just refill actually..
synaptic plasticity
dendritic morphology
neurogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

first generation antidepressants

A

TCA, MAO-I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

second generation antidep

A

SSRI, SNRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

5 serotonin SSRIs

A 
citalopram
escitalopram
fluoxteine
paroxteine
fluvoxamine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

serotonin TCA

A

clomlpramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

NE SNRI

A

venlafaxine
desvenlafaxine
duloxetine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

NE TCA

A

nortyptillineimipramine
amitriptylline
desipramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

DA NDRI

A

bupropion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MAOI

A

phenelzine

tranylcipramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

citalopram mech of action

A

blocks 5ht reuptake transporter so 5ht stays in synase

can also block DA and NE reuptake by binding to 5HT R

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

citalopram also

A

bidnds to closely related 5HT receptors

histamine, DA, muscarinic (dryness), a and b adrenergic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

where are 5HT receptors mostly?

A

raphe nucleus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

side effects citalopram (celexa)

A

GI, sexual, sleep, sweating, Na_, mania

QT prolongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

venlafaxine side effects

A

GI, sexual, sleep, sweating, Na_, mania

diastolic blood pressure increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

why were tertiary amines bad?

A

they block Na+ channels in heart, so if you overdose you can get heart block, but secondary are better (all same but weaker side effects)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

different between teritary (imipramine/amitriptyline) and secondary (desipramine/nortriptyline) amines

A

react more with 5HT than NE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

tertiary amines work as

A

Class 1A anti-arhythmics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

nortriptyline side effects

A

wt gain, sedation, Ach, hypotension, arrhythmia, sexual, sweating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

nortriptyline is___in overdose

A

lethal

20
Q

chlomipramine is

A

highly specific to 5HT, so its better for OCD

21
Q

NDRI

A

NE-DA reuptake I

wellbutrin/bupropion

22
Q

side effects wellbutrin

A

insomnia
tremor
tinnitus
seizures

23
Q

how do MAOIs work?

A

suicide inhibitors; complelety kills enzyme; doesnt just block enzyme by occupying space, but gets rid of enzyme

24
Q

even if you stop an MAOI

A

2 weeks until body makes new enzyme

25
Q

Phenelzine (nardil)

A

developed as TB drug, sedating (MAOI)

26
Q

tranylcypromine (parnate)

A

developed as amphetamine- stimulating

27
Q

serotonin syndrome triad

A

MS seizures
autonomic instablility
neuromuscular signs

28
Q

clinically, 5ht syndorme..

A

hypertensive crisis
seizure
stroke

29
Q

hypertensive crisis

A

“cheese syndrome”

low tyramine diet needed (because tyramine is a precursor to D and NE)–>SS

30
Q

NaSSA

A

dual reuptake

Mirtazapine (remeron)

31
Q

do not combine Mirtazpine with

A

P450 drugs (other MAOIs)

32
Q

side effects Mirtazpine

A

sedating, wt gain (histamine)

33
Q

SARI

A

serotonin 2A antagonist dual reuptake
Nefazodone
trazodone
*can combine with P450 drugs

34
Q

GABA drugs

A

benzodiazepines

35
Q

what are benzos good for

A 
sedative
anziolytic
seizure control
muscle relaxant
anterograde amnesia
36
Q

benzos should never be

A

combined witha lcohol

37
Q

benzos act as

A

positive allosteric modulator

  • -increase R affinity for endogenous GABA
  • -increase frequency of opening of CL channel when activated by GABA (and Cl makes resting potential more negative–higher activation energy)
38
Q

Diazepam is…and binds tooo

A

nonselective

binds to all alpha R wherever they are in brain

39
Q

side effects diazepam (valium)

A 
sedation
depression
amnesa
ataxia
dependence
withdrawal
40
Q

valium/diazepam is metabolized by the

A

liver

41
Q

which benzo is renally cleared?

A

lorazapam

42
Q

Zolpidem

A

alpha 2 selective BZD agonist
zolpidem
zalapion
eszopiclone

43
Q

zolpidem binds

A

preferentially to a1 receptors

44
Q

zolpidem is mostly for

A

sedation

forget what you did

45
Q

Buspirone/BuSPar

A

5HT1A partial agonist

for GAD/Augment MDD

46
Q

side effects buspirone

A

dizziness, sedation, nervous/restless

47
Q

how long for buspirone to work

A

4 weeks, but no withdrawal after

PSYCH (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions