SAS 2: Inflammation and Disorders of Growth Flashcards
From the Latin word “inflammare” to set fire
Inflammation
Universal response to tissue damage by wide range if harmful stimuli including mechanical trauma, tissue necrosis and infection.
Inflammation
Changes during inflammation
- Blood vessel
- Blood stream
- Changes in rate of flow
- Leukotic emigration
- Diapedesis of RBC
- Serum exudation
Momentary contraction of blood vessel
Blood vessel changes
Vessel dilation causing atrial blood
Blood vessel changes
Increase permeability of venules and capillaries. Its effect is leakage of plasma proteins, RBC and WBC
Blood vessel changes
Changes in Erythrocyte distribution
Change in the blood stream
Leukocyte migration (pavement). Its mechanisms is either :
a. WBC gets adhesive
b. Capillary wall gets sticky (endothelium gets sticky)
change in blood stream
Accelerate of the rate due to arteriolar dilation
Change in rate of flow
Retardation due to :
1. Fluid loss leads to increase blood viscosity
2. Leukocytes stickiness
Change in rate of flow
Stasis: well established congestion that favors, molecular and cellular escape i.e exudation
Change in rate of flow
Ameboid movement of the leukocytes towards the site of inflammation cause CHEMOTACTIC FORCES
Leukocytes emigration
Process of attraction of leukocytes to certain area that has the chemotactic substances
Chemotaxis
The action is phagocytic
Neutrophils
It will produce pus and this process call suppuration or purulent exudate
Neutrophils
Mast cell and release of histamine
Eosinophils
These cells present in the parasitic infection and hypersensitivity due to release of ———– chemotactic factor from mast cells when intact with Ag+lgE to mast cells & release of histamine
eosinophils
-It is phagocytes cells inside the blood & when reach to the cells and tissue it will become macrophage cells or called histiocytes
Monocytes
-They fuse to form multi nucleated giant cells(Langhan’s giant cell.)
Monocytes
-The function of macrophage is phagocytes foreign body
-Removed(scavengers)the debris
Monocytes
It’s similar to macrophage and similar to epithelial cells close to each other with no different borders between its cytoplasm & they tend to have small nucleus
Epithelioid cells
These cells are no phagocytic cells but release lysosomal enzyme.
Epithelioid cells
Form by fused the cytoplasm of the macrophages(2–3 or reach to 20).
Giant cells
What are the 4 types of Giant Cells?
1.Langhan’s giant cell
2.Foreign body giant cells
3.Touton Giant cell
4.Warthin-Finkeldy
Phagocytic power is seen in Bacteria
Neutrophils
