Routes of Administration - EENT Flashcards
Sinisitis
- Inflammed with obstructed sinus opening
- fluid filled
What does local delivert target?
Allergic rhinitis, congestion, infection
Systemic absorption
Migraine, diabetes insipidus, prostate cancer, endometriosis, osteoporosis, nicotine
Kiesselbach’s plexus
- Vacular network formed by a five arteries that supply oxygened blood to the nasal septum
Respiratory epithelium
- Columnar cells (ciliated or non-ciliated)
- Goblet cells
- Basal cells
Mucus
- From serous glands and goblet cells
- Form viscous gels due to high molecular weight mucins and ability to form disulphide bridges
- Function: clearance and air conditioning
Steroid nasal sprays
- Decrease inflammation
Alpha-adrenergic agonist and antihistamine
- Used as a decongestant
Saline
- A more ‘natural’ remedy to treat blocked noses
Menthol nasal spray
- Provide short-term relief from the discomfort of nasal congestion
Intranasal peptides
Desmopressin
Control increased thirst and too much urination
Intranasal peptides
Buserelin
treat hormone-responsive cancers (prostate cancer, premenopausal breast cancer)
Intranasal peptides
Nafarelin
treat symptoms of endometriosis (pelvic pain, menstrual cramps, painful intercourse)
Treatment for sore throats
Benzydamine exerts an anti-inflammatory and analgesic action by stabilising the cellular membrane and inhibiting prostaglandin synthesis
Tonsilitis
- Give Difflam or Strepsils