Rifampicin (Rifedin)

Question 1

Class

Answer 1

Rifamycins

Question 2

Indications

Answer 2

TB

MRSA

Question 3

Dose Range

Answer 3

10mg/kg (m=600mg) daily

Question 4

Counselling/SE

Answer 4

• 30 mins before food
• stopping suddenly –> flu like symptoms
• discolouration of bodily fluid –> orange (urine, faeces, swear, tears)
• tell dr if you have loss of appetite, nausea, vomiting, unusual tiredness, jaundice, dark urine, pale stools –> hepatic damage
• use other contraception –> OC less effective
• interacts with many meds

SE:

• GI irritation (n/v, cramps, diarrhoea)
• orange-red discolouration of body fluids
• staining of soft contact lenses
• rash
• increase liver enzymes
• arthralgia, myalgia
• CNS (dizziness, headache, ataxia, confusion)
• hepatotoxicity

Question 5

Monitoring

Answer 5

• compliance

- signs of hepatotoxicity