Hydrochloroquine (plaquinil)

Question 1

Class

Answer 1

Rheumatoid and antimalarial drug

Question 2

Indications

Answer 2

Rheumatoid arthritis

Prophylaxis and treatment of malaria

Question 3

Dose Range

Answer 3

RA, 200 – 600 mg daily

Malaria
Prophylaxis, 400 mg weekly

Treatment, 2g over 48 hours

Question 4

Counselling/SE

Answer 4

• with food
• photosensitivity
• problems with vision –> SEE DOCTOR

SE:

• GI upset (n/d, anorexia, abdo pain)
• hair loss
• ototoxicity (vertigo, tinnitus, nerve deafness)
• ocular toxicity (retinopathy, corneal changes)
• muscle weakness

Question 5

Monitoring

Answer 5

• compliance

- signs of ototoxicity and ocular toxicity