agomelatine 25mg 1 n (Valdoxan)

Question 1

Class

Answer 1

melatonin receptor agonist and 5HT2C receptor antagonist

Question 2

Indications

Answer 2

Major depression

Question 3

Dose Range

Answer 3

25 mg at bedtime; increase to 50 mg at bedtime after 2 weeks if necessary

Question 4

Counselling/SE

Answer 4

• Dizziness/drowsiness –> don’t drive
• dark urine, pale stools or yellow skin or eyes –> SEE DOC IMMEDIATELY

SE:

• dizziness
• abdominal pain
• blurred vision
• somnolence
• hepatitis (rare)

Question 5

Monitoring

Answer 5

• regular psychiatric review to monitor for compliance, tolerability and worsening of condition
• dark urine, pale stool or yellow skin/eyes (hepatitis)