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AMK > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

Methotrexate s/e

A

Hepatotoxicity

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2
Q

What is systemic sclerosis ?

A

Autoimmune connective tissue disorder

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3
Q

Treatment for systemic sclerosis

A

CCBs, avoid changes in temperature

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4
Q

Sx systemic sclerosis

A 
C = calcinosis 
R = Raynaud's
E = oesophageal dysmotility 
S = sclerodactyly 
T = telangieostasia
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5
Q

What is Marfan’s syndrome ?

A

Mutation in fibrillin-1 gene

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6
Q

Dx Marfan’s

A

Ct

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7
Q

treatment for Marfan’s

A

B blockers

ECG

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8
Q

Sx Marfan’s

A

Long thumbs and arm
Aortic dissections
Hypermobility

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9
Q

Sx gout

A

Swelling and flare ups
Erythema
1st MTP affected first

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10
Q

Treatment for gout

A

Allupurinol and colchicine

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11
Q

Ix gout

A

-vely birefringent needle shaped urate crystals

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12
Q

Sx pseudo gout

A

Knee, wrist and shoulders mainly affected

Chondrocalcinosis

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13
Q

Ix pseudo gout

A

+ve birefringent rhomboid shaped crystals

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14
Q

Management of pseudo gout

A

Aspirate join fluid and steroids

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15
Q

What are the crystals made of in pseudo gout

A

Calcium phosphate

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16
Q

Reactive arthritis sx

A

Can’t see = conjunctivitis
Can’t pee = urethritis
Can’t climv a tree = arthritis

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17
Q

Which HLA is associated with reactive arthritis

A

HLA-B27

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18
Q

Treatment for reactive arthritis

A

Rest
NSAIDS
DMARDs

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19
Q

HLA for ankylosing spondylitis

A

HLA B27

20
Q

Sx ankylosing spondylitis

A

Pain in bum/lower back
Pain decreases with exercise
Spinal stiffness
IBD

21
Q

Dx ankylosing spondylitis

A

Pain with pressure on sacrum

<30 with morning stiffness >30 mins

22
Q

Investigations ankylosing spondylitis

A

Sacroilitis in early stages

Bamboo spine in late stages

23
Q

Treatment ankylosing spondylitis

A

Exercise and NSAIDs

24
Q

What is poly myalgia rheumatica

A

Inflammation of shoulders, neck and pelvis

25
Q

Sx polymyalgia rheumtica

A

Morning stiffness, distal joints initially spared, bilateral pain

26
Q

Treatment for polymyalgia rheumatica

A

Steroids

27
Q

What is giant cell arteritis

A

Inflammation of medium-large arteries

28
Q

Sx giant cell arteritis

A

Headaches, vision loss, scalp and jaw pain

29
Q

Treatment for giant cell arteritis

A

Prednisolone

30
Q

What is fibromyalgia?

A

Pain all over body

31
Q

Sx fibromyalgia

A

Morning stiffness
Analgesia ineffective
Pain worse with stress/cold etc

32
Q

Dx fibromyalgia

A

Pain in 11/18 specified places

33
Q

Management fibromyalgia

A

Pregabalin, duloxetine and amitriptyline

34
Q

What is Ehler’s dances syndrome

A

Connective tissue disorder due to defective collagen synthesis

35
Q

Sx Ehler-danlos

A

Flat feet
Poor healing
Aneurysms

36
Q

Most common subtype of Ehlers danlos

A 
Vascular subtype (collagen 3)
Easy bruising and aneurysms
37
Q

What is the classical subtype of ehler’s danlos

A

Hyperelastic skin = collagen 3

38
Q

Treatment ehler’s danlos

A

No treatment

39
Q

What is Behcet’s syndrome?

A

Autoimmune inflammation of arteries and veins

40
Q

HLA associated with Behcet syndrome

A

B51

41
Q

Sx Behcet syndrome

A

Oral ulcers, painful genital ulcers and anterior uveitis

42
Q

Treatment for Behcet’s syndrome

A

Steroids and colchicine

43
Q

What is SLE ?

A

Autoimmune connective tissue disease

44
Q

Sx SLE

A 
Photosensitive rash on face 
Malaise
Fever
Arthritis 
Nephrosis
45
Q

Mx SLE

A

NSAIDs or DMARDS

AMK (33 decks)

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