Obstetrics Flashcards
Average blood loss per menstrual cycle
30-40 mls
Treatment for heavy menstrual bleeding
First line is antiprostaglandins - NSAIDs and TXA
COCP is second line
What is primary amenorrhoea?
Pt never had period
When should you investigate for primary amenorrhoea ?
14yo girl with no breasts
15 yp girl with breasts
Causes of secondary amenorrhoea
HPA axis unbalanced - stress, hyperthyroidism, disease
What is placenta accreta
Placenta is unusually adherent to uterine lining
Sx placenta accrete
Painless vaginal bleeding, foetus is often in abnormal lie
sx placental abruption
woody uterus
single instance of large blood loss
contractions
Management placenta praaevia
If >24 weeks should go to ED
O2 and blood match
Treatment of bacterial vaginosis
Metronidazole and clindamycin
What is Ca125 a marker for ?
ovarian cancer
Which palsy is associated with shoulder dystocia?
Erb’s - c5-7
Most common place for ectopic
Ampulla
Gold standard to diagnose ectopic pregnancy
laparascopuy
Most common form of endometrial cancer
Adenocarcinoma of columnar cells
Sx endometrial cancer
Post-menopausal bleeding
Tx endometrial cancer
Hysterectomy with bilateral salpingo-oophorectomy
Cause of endometritis
Pregnancy
GBS
Management endometritis
Clindamycin and gentamicin
What is adenomyosis
endometrial tissue grows inside myometrium
sx adenomyosis
boggy uterus
dysmenorrhoea
Most common type of cervical cancer
sqmaous cell
Sx cervical cancer
abnormal vaginal bleeding/discharge
screening programme cervical cancer
every 3 years from 25-49 and every 5 from 50-64
treatment for 1A cervical cancer
LLETZ
treatment for 1B-2A cervical cancer
hysterectomy
treatment for 2B-4A cervial cancer
chemo and radiotherapy
vulval cancer
- Squamous cell tumours
- R/F = HIV
- Sx = lumps + itching + pain
endometrial cancer
- Adenocarcinoma
- Exposure to oestrogen
- Post-menopausal bleeding
Missing POP
take pill ASAP and use protection for 48h - emergency contraception needed if had sex since missing pill
symptoms of PCOS
- Oligo-ovulation/anovulation
- Hyperandrogenism (hirsutism, acne, alopecia)
- Polycystic ovaries
hormone levels PCOS
- Increased LH and testosterone
- FSH normal
- High oestrogen
management PCOS
- Lifestyle changes and weight loss
- COCP to protect against endometrial cancer
What is premature ovarian insufficiency
menopause <40 years
medical management of miscarriage
mifepristone pessary
medical abortion <7 weeks
mifepristone (progesterone antagonist) + mifepristone
Pre-eclampsia
Spiral arteries have increased resistance = reduced blood flow to placenta = inflammation
Sx pre-eclampsia
headaches, visual changes and oedema
Ix pre-eclampsia
BP and urinalysis
Mx pre-eclampsia
labetolol and c-section
what is eclampsia
seizures due to pre-eclampsia , increased BP, proteinuria
mx eclampsia
magnesium sulphate
HELLP syndrome
inflammatory complications due to pre-eclampsia
mx HELLP
IV labetolol
why do you give magnesium sulphate in eclampsia?
prevent seizures
treatment pregnancy induced hypertension
magnesium sulphate
pathophysiology of Rh -ve pregnancies
When a Rh -ve mum has a Rh +ve baby, fetal RBCs can leak across to the placenta. Mum then makes anti-D IgG antibodies which can attack baby
Sx in baby if mum -Rhve and baby +ve
hydrops fetalis (oedema), jaundice (kernicterus), heart failure and anaemia. Can be treated with transfusion and phototherapy
anti-D needs to be given <72h when…
- TOP
- Baby +ve (live/stillborn)
- Miscarriage >12w
- Ectopic pregnancy managed surgically
- External cephalic version
- Antepartum haemorrhage
- Invasive testing (amniocentesis, CVS, fetal blood test)
- Abdo trauma
Coombs test
tests for antibodies in RBCs of baby
Kleihauer test
add acid to maternal blood - fetal cells resistant
What is alpha feta-protein?
Secreted from GIT and yolk sac in developing foetus - test for in 16-18w testing
Reasons for high AFP
Neural tube defect (meningocele, myelomeningocele, anencephaly)
Abdominal wall defect (omphalocele, gastroschisis)
Multiple babies
Reasons for decreased AFP
Aneuploidy
Maternal DM
Spina bifida occulta
Spinal laminae of L5 +/- S1 fail to unite, produces no symptoms - has small dimple and tuft of hair at base of spine
Meningocele
Protrusion of meninges and CSF
Myelomeningocele
Protrusion of meninges, CSF and spinal cord
Anencephaly
Absence of skull and cerebral hemispheres
Gastroschisis
Herniation of abdo contents without peritoneal covering lateral to umbilicus
Omphalocele
Herniation of abdo contents with umbilical covering through umbilicus
frank breech
hips flexed, knees extended
footling breech
one or both knees extended, hips extended
why is breech dangerous?
risk of cord prolapse
ECV should be attempted when?
36w
when should you NOT attempt ECV
c-section required, abnormal CTG, membranes already ruptured, multiple pregnancy
Define PPH
Blood loss >500ml after birth
causes of PPH
- Tone (uterine atony is most common cause)
- Trauma (perineal tear)
- Thrombin (clotting disorder)
- Tissue (retained tissue)
RF PPH
- Previous PPH
- Long labour
- Hypertension
- Increased maternal age
- Placenta accreta/praevia
Define primary PPH
<24h of delivery
Mx primary PPH
- Mx: oxytocin, ergometrine and carboprost to stimulate uterine contractions
- Intrauterine balloon tamponade is surgical first line when atony is cause
Define secondary PPH
24h-6w after delivery
Management secondary PPH
ampicillin and metronidazole, uterotonics (oxytocin, ergometrine, carboprost)
What is pre-eclampsia?
BP >140/90 after week 20 of pregnancy (this can cause placental abruption/haemorrhagic stroke)
Triad of pre-eclampsia symptoms
hypertension, proteinuria and oedema
baby complications pre-eclampsia
IUGR and prematurity
What is severe pre-eclampsia
BP >160/110
sx severe pre-eclampsia
Increased proteinuria, vision problems, headaches, abnormal liver enzymes
agreement severe pre-eclampsia
admit for observation
what is eclampsia
tonic-clonic seizures
what is HELLP?
Haemolysis, elevated liver enzymes and low platelets → can be associated with placental abruption and DIC
Sx HELLP
Bleeding/bruising, headache, fatigue, microcytic anaemia. RUQ pain, blurry vision, hypertension
Blood results HELLP
Schistocytes and increased UCB (haemolysis)
Elevated ALT and AST
Low platelets and high bleeding time
Anaemia
management HELLP
dexamethasone
managing pre-eclampsia/eclampsia/HELLP
- Definitive treatment is to deliver baby if after 34 weeks - if before this time then give corticosteroids (surfactant)
- Management includes antihypertensive therapy (labetolol), aspirin from 12w gestation, and magnesium sulfate to minimise seizures
when do you give anti-D
28 and 34 weeks
Define antepartum haemorrhage
> 24 weeks
Baby blues features
irritability, tearfulness, anxiety -> normally 3-7d post-birth, common in primps
treatment baby blues
SR
features of post partum depression
Start within 1m of birth, peaks at 3m. mothers are aggressive, stressed and detached
tx post partum depression
normally SR but can give sertraline/paroxetine/CBT
puerperal psychosis features
severe mood swings and altered perception, normally starts within 2-3 weeks of birth
treatment puerperal psychosis
ADMIT
how to assess post partum depression
Edinburgh Postnatal Depression Scale - a score >13 indicates some level of depression
When do you screen for anaemia?
booking (8-10 weeks) and 28 weeks
Management pregnancy anaemia
ferrous fumarate/sulfate, continue 3m after anaemia resolved
Cut off in pregnancy for treatment for anaemia
Tri1 = <110
Tri2/3 = <105
Postpartum = <100
sx intrahepatic cholestasis pregnancy
pruritus wo rash, high bilirubin (dark urine and light poo)
mx intrahepatic cholestasis pregnancy
ursodeoxycholic acid, induce at 37w
sx acute fatty liver of pregnancy
- Abdominal pain
- N and V
- Headache
- Jaundice
- Hypoglycaemia
- Raised ALT
mx acute fatty liver of pregnancy
delivery
obesity definition
BMI >30 at first visit
what is puerperal pyrexia
temp >38c in first 2 weeks following delivery
causes puerperal pyrexia
endometritis, UTI, wound infection
mx puerperal pyrexia
IV ABx (clindamycin and gentamicin)
Which women should have HIV screening?
All
Which women should be offered ARVT?
all
when can pregnant women with HIV breast feed?
Never
Options for delivery depending on viral load
If <50, vaginally
If >50, give zidovudine infusion for 4h then c-section
neonatal ARVT depending on viral load
<50 give zidovudine
>50 needs triple ARVT for 4-6w
how to deal with hep b in pregnancy?
babies born to +ve mothers or those infected in pregnancy should receive full vaccination and immunoglobulin
most common cause of neonatal infections
GBC
When do you screen a woman for GBS
Not routine - only if labour pre-term or mother pyrexic
How do you treat a nmother if she had previous GBS infection?
- Chance of another infection is 50%
- Give benzylpenicillin
- Swab at 35-37 weeks
first line treatment for vomiting in pregnancy
anti-histamines e..g prochlorperazine
sx foetal varicella syndrome
skin scarring, eye defects, microcephaly, learning difficulties
how to treat mothers infected with varicella zoster
- ≤ 20w seek advice
- ≥ 20w oral aciclovir
prophylactic care for mothers who come into contact with varicella zoster
- Check mother’s blood for IG
- ≤20w: VZIG ASAP (up to 10d post-exposure)
- ≥ 20w: VZIG or aciclovir (7-14d post-exposure)
complete hydatiform mole
empty egg + normal sperm
partial mole
normal egg + 2x sperm
why do you need surgical management of hydatiform moles
ensure complete evacuation and stop choriocarcinoma development
sx molar pregnancy
large uterus for dates, morning sickness, high HCG
sx congenital rubella syndrome
- Sensorineural deafness
- Cataracts
- Heart disease
- ‘salt and pepper’ chorioretinitis
- Stunted growth
- Cerebral palsy
tx rubella in pregnancy
discuss with PHE, isolation
epilepsy drugs in pregnancy
Sodium valproate shouldn’t be prescribed (neural tube defects)
Phenytoin = risk of cleft palate
Carbemazepine and lamotrigine are okay, dose of lamotrigine may need to be increased
when do you give aspirin in pregnancy? (remember cant give BF)
high risk groups (CKD, autoimmune disorder, DM)
What normally happens to BP in pregnancy
Normally, BP falls in first trimester (especially diastolic) and then rises to normal levels by birth
Define hypertension in pregnancy
- Systolic >140, or >30 from booking reading
- Diastolic >90, or >15 from booking reading
Pros and cons breastfeeding
Pros: bonding, protection against breast and ovarian CA, unreliable contraceptive effect
Cons: transmission of drugs/disease, vit D/K deficiency, breast milk jaundice
Drugs CI whilst breastfeeding
- Amiodarone
- Metronidazole
- Sulfonylureas
- Aspirin
- Lithium/benzos
- ABx: ciprofloxacin, tetracycline, chloramphenicol
Best SSRI if breast feeding
sertraline
Blocked breast duct sx and mx
sx: pain when breast feeding
mx: continue feeding
candidiasis sx and mx
sx: painful, sore/cracked/itchy nipples
mx: miconazole for mum, nystatin for baby
mastitis sx and mx
sx: tender, hot, breasts with decreased milk supply and systemic upset
mx: flucloxacillin 14d
engorgement sx and mx
sx: occurs within first few days of birth, bilateral and worse before feeding
mx: hand-expressing milk
Raynaud’s sx and mx
sx: intermittent pain during/just after BF, nipple may blanch -> cyanotic -> erythematous (pain resolves)
mx:nifedipine if persistent, if not then minimise RF (extreme temp exposure)
galactocele sx and mx
sx: recently stopped BF - is due to occlusion of lactiferous duct. Milk build up creates cystic lesion and is usually painless with no infection
mx: conservative
When should you expect to feel foetal movements by ?
20 weeks
Define RFM
<10 movements within 2h
Causes of RFM
Poor posture, foetal sleeping periods, distractions, IUGR, hypothyroidism
mx no foetal movements by 24 weeks
refer to foetal medicine unit
mx RFM <24 weeks and movements previously felt
handheld doppler should be used to confirm foetal heartbeat
mx RFM 24-28w
use handheld doppler
RFM after 28 weeks
handheld doppler should be used to confirm foetal heartbeat - if this is negative, immediate USS, if this is positive, CTG for 20 mins. If concerned despite normal CTG, urgent USS
mx more than 1 episode of RFM within 3 months
doctor review
RF gestational diabetes
- High BMI
- Previous macrosomic baby >4.5kg
- Previous GD
- First-degree relative with diabetes
- Family origin from somewhere with high diabetes prevalence (South Asian, Caribbean, middle eastern)
Screening for gestational diabetes
- If previous GD: OGTT at booking and at 24-28 weeks
- If risk factors: OGTT at 24-28 weeks
Diagnosis gestational diabetes
- Fasting glucose >5.6
- 2-hr glucose >7.8
Management of new onset GD
- Lifestyle changes for 1/2 weeks → add metformin → add insulin
- If fasting glucose >7 → insulin straight away
management of pre-existing diabetes
stop everything apart from metformin and start insulin