Restrictive Lung Disease/ Muthiah Flashcards

1
Q

Define restrictive lung disease

A

Disease in which the expansion of the lungs is impeded and the lungs cannot fill. Sort of counterintuitive since it seems like obstructive lung disease would prevent filling. It does not, it prevents emptying.

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2
Q

Restrictive disease that is parenchymal involves

A

functional lung tiissue injury. Parenchyma is just the bulk of an organ. The functional part.

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3
Q

Two types of parenchymal disease

A

Interstitial lung disease and resection of the lung tissue

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4
Q

Interstitial diseases generally involve what part of the parenchyma

A

alVEOLAR CONNECTIVE TISSUE

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5
Q

Asbestos, coal, silica cause granulomatous or non-granulomatous ILD

A

Non

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6
Q

What drugs can cause Non granulomatous ILD

A

Amiodarone, Bleomycin

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7
Q

The Hypoxia of ILD is due to

A

V/Q mismatch

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8
Q

Four lab characteristic of ILD

A

hypoxemia, hypercapnea, widened A-a gradient, exercise induced hypoxia

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9
Q

Most common symptom of ILD

A

Dyspnea….then cough and chest pain

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10
Q

Clubbing is a sign of

A

lung and heart disease…think thorax problems

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11
Q

Three stades of radiography

A
  1. ) Alveolar filling
  2. ) Interstitial
  3. ) Honeycombing
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12
Q

Example of a pleural disease

A

mesothelioma…leads to compression of the lung

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13
Q

Non-parenchymal causes of restrictive lung disease

A

Neuromuscular, chest wall problem, pleural problem

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14
Q

Bronchial Breath sounds are a sign of

A

Conolidation…Remember how it works…because there is so much fluid in the lungs, regular breath sounds from the trachea are conducted through the lungs

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15
Q

Aspiration pneumonia is usually caused by what?

A

Bacteria

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16
Q

Inhalation pneumonia is usually caused by?

A

Virus

17
Q

Can ARDS be a complication of pneumonia

A

It can be and is often a complication of pneumonia

18
Q

Whats the first thing that improves during antibiotic treatment of pneumonia>

A

Clinical improvement is first, respiration rate will decrease. CXR will not show improvement until later.

19
Q

What type of pneumonia is generally to blame for rapid deterioration of pt health

A

Staph…specifically MRSA

20
Q

Drug of choice for MRSA

A

Vancomycin

21
Q

Risk factors for CAP

A

Very young and very old.
Smoking and alcohol use predispose
Comorbidities include: COPD, CHF, Liver and kidney disease, Cancer, Diabetes
IMMUNODEFICIENT STATES, ASPLENIA

22
Q

Cystic fibrosis mutation on

A

Chromosome 7

23
Q

S1Q3T3 mutation predisposes to

A

Pulmonary embolism….Only seen in a minority of cases

24
Q

Most common mutation predisposing to hypercoaguable state

A

Factor V Leiden

25
Q

What is the importance of the factor V leiden mutation

A

It inactates Protein C which is a natural anticoagulant

26
Q

Frequent causes of hypercoaguable state

A

Estrogen use, hormonal changes, malignancy, thrombocytosis

27
Q

If scan is normal or D-dimer is less than 500, the probablility of PE

A

is extremely low